Results 21 to 30 of about 180,223 (258)
Toll-like receptor 1 inhibits Toll-like receptor 4 signaling in endothelial cells [PDF]
European Journal of Immunology, 2002 Toll-like receptor 4 (TLR4) is the signal-transducing component of the LPS recognition complex and is essential for LPS-induced septic shock. Here we demonstrate that TLR1 has the capacity to abrogate TLR4 signaling. Human microvascular endothelial cells express TLR4 but not TLR1 and respond to LPS through TLR4. The ability of these cells to respond to
Jessica H, Spitzer +4 more
openaire +2 more sources
Patologìâ, 2020 Aim. To determine the pathogenetic role of Toll-like receptors-4 (TLRs-4) in the development of anemia of inflammation (AI). Materials and methods.
H. O. Lezhenko, A. O. Pogribna
doaj +1 more source
Computational Approaches to Toll-Like Receptor 4 Modulation [PDF]
Molecules, 2016 Toll-like receptor 4 (TLR4), along with its accessory protein myeloid differentiation factor 2 (MD-2), builds a heterodimeric complex that specifically recognizes lipopolysaccharides (LPS), which are present on the cell wall of Gram-negative bacteria, activating the innate immune response.
Jean-Marc Billod +3 more
openaire +4 more sources
Zdorovʹe Rebenka, 2013 Currently studying the mechanisms of recognition of foreign agents, which is implemented by Toll-like receptor of innate immune system, has become one of the main tasks of clinical immunology.
T.O. Kryuchko +2 more
doaj +1 more source
Biomedicines, 2023 Toll-like receptor 4 (TLR4) can activate pro-inflammatory cascades in the gastrointestinal tract. Our aim was to determine TLR4 expression in myenteric neurons of different gut regions using a type 1 diabetic model.
Nikolett Bódi +7 more
doaj +1 more source
Toll-like receptor 2 and Toll-like receptor 4 predict favorable prognosis in local pancreatic cancer
Tumor Biology, 2018 Toll-like receptors play an essential role in our innate immune system and are a focus of interest in contemporary cancer research. Thus far, Toll-like receptors have shown promising prognostic value in carcinomas of the oral cavity, colon, and ovaries ...
Mira A Lanki +6 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Background: Parkinson’s disease (PD) is characterized by intraneuronal α-synuclein aggregation called Lewy bodies and progressive dopaminergic neurodegeneration. Toll-like receptor (TLR) signaling is a major pathway mediating inflammation.
Lucia Yi-Ru Chung +7 more
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The role of Toll-like receptors in skin diseases
Przegląd Dermatologiczny, 2014 The innate immune system has the ability to recognize pathogens through Toll-like receptors (TLRs), which are transmembrane glycoproteins on the cell surface.
Joanna Bacharewicz +2 more
doaj +1 more source
Toll-like receptors (TLR) 2, 3, and 4 gene polymorphisms in critically ill patients [PDF]
Archives of Biological Sciences, 2015 Considering that TLR2, TLR3 and TLR4 play very important roles in inflammatory processes, the question arises whether the presence of polymorphisms in these genes is associated with susceptibility to sepsis.
Elkilany Atia +5 more
doaj +1 more source
Gut flora enhance bacterial clearance in lung through toll-like receptors 4
Journal of Biomedical Science, 2011 Background The influence of the gut flora on lung inflammatory reaction against bacterial challenge remains undefined. This study was designed to investigate whether gut flora enhances lung defense against E.coli pneumonia through TLR4 signaling. Methods
Hsu Ching-Mei +4 more
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