Phytochemicals targeting Toll-like receptors 4 (TLR4) in inflammatory bowel disease [PDF]
Chinese Medicine, 2022 Inflammatory bowel disease (IBD) is a collective term for inflammatory diseases including Crohn’s disease and ulcerative colitis. Toll-like receptor 4 (TLR4) is thought to play a key role in the pathogenesis of IBD. Inhibition of TLR4 has been recognized
Wenbin Dai +4 more
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Associations Between Serum Soluble Toll-like Receptors 4 and 9 and Breast Cancer in Egyptian Patients [PDF]
Cancer Control, 2023 Background Toll-like receptors (TLRs) play an important role in regulation of immune cells and are vital in tumorigenesis due to its crucial role in inflammatory microenvironment regulation, as they promote the synthesis and release of inflammatory ...
Inas Moaz +11 more
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Endoplasmic reticulum stress regulates inflammation in adipocyte of obese rats via toll-like receptors 4 signaling [PDF]
Iranian Journal of Basic Medical Sciences, 2018 Objective(s): To explore whether endoplasmic reticulum (ER) stress regulates inflammation in adipose tissue of obese rats via TLR4 signaling. Materials and Methods: Sprague Dawley rats were randomly divided into four groups, and body weight, food intake,
Xiaohua Li
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Toll-Like Receptor (TLR)-9 rs352140 Polymorphism is an Immunopathology Protective Factor in Parkinson's Disease in the Northern Iranian Population [PDF]
Iranian Journal of Immunology, 2020 Background: Neuroinflammation and immunopathology in Parkinson's disease (PD) are believed to be associated with genetic and environmental factors. Objective: We conducted the current study to evaluate the Toll-like receptors (TLR4 and TLR9) genes ...
Niloufar Sadat Miri +4 more
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Critical Care Explorations, 2021 OBJECTIVES:. Refractory vascular failure due to the inability of vascular smooth muscle to respond to vasoconstrictors such as phenylephrine is a final common pathway for severe circulatory shock of any cause, including trauma/hemorrhagic shock ...
Rafi Mazor, PhD +5 more
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How Toll-like receptors influence Parkinson’s disease in the microbiome–gut–brain axis
Frontiers in Immunology, 2023 Recently, a large number of experimenters have found that the pathogenesis of Parkinson’s disease may be related to the gut microbiome and proposed the microbiome–gut–brain axis.
Ziyi Zhang +4 more
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Toll-like Receptors 2, 3, and 4 in Childhood Acute Lymphocytic Leukemia
Revista Brasileira de Cancerologia, 2023 Introduction: Acute lymphocytic leukemia (ALL) is the most common cancer type in children and accounts for 80% of pediatric leukemias. Novel targets are necessary to improve survival rates for refractory and relapsed disease.
Matheus Loureiro da Silva Cruz +11 more
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Медицинский вестник Юга России, 2022 Objective: to study the dynamic changes in the content of monocytes expressing Toll-like receptors of type 2, 4 and 9 in military personnel under occupational stress.
N. S. Zaitseva, L. P. Sizyakinа
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Up-regulation of Toll-like receptors 2, 3 and 4 in allergic rhinitis
Respiratory Research, 2005 Background Toll-like receptors enable the host to recognize a large number of pathogen-associated molecular patterns such as bacterial lipopolysaccharide, viral RNA, CpG-containing DNA and flagellin.
Uddman Rolf +5 more
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Antimicrobial peptides could antagonize uncontrolled inflammation via Toll-like 4 receptor
Frontiers in Bioengineering and Biotechnology, 2022 Antimicrobial peptides are part of the organism’s defense system. They are multifunctional molecules capable of modulating the host’s immune system and recognizing molecules present in pathogens such as lipopolysaccharides (LPSs).
Danieli F. Buccini +4 more
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