Results 171 to 180 of about 4,939 (213)

Toll‐like receptors and skin

Journal of the European Academy of Dermatology and Venereology, 2011
AbstractToll‐like receptors are important pattern recognition receptors which have key roles in both innate and adaptive immune responses. They are strongly associated with the pathogenesis of inflammatory and autoimmune diseases. Furthermore, Toll‐like receptors have also been implicated in the pathogenesis of several skin diseases such as skin ...
Gunduz, K., Ozturk, FERDİ, Ermertcan, A. T.   +2 more
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The Toll of Toll-Like Receptors, Especially Toll-Like Receptor 2, on Murine Atherosclerosis

Current Drug Targets, 2007
At one time, atherosclerosis was thought to be a simple lipid storage disease. However, it is now recognized as a chronic and progressive inflammation of the arterial wall. Gene deletion experiments in murine models of atherosclerosis that reduce the inflammatory process also reduce disease severity.
L K, Curtiss, P S, Tobias
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The biology of Toll-like receptors

Cytokine & Growth Factor Reviews, 2000
In 1997, a human homologue of the Drosophila Toll protein was described, a protein later to be designated Toll-like receptor 4 (TLR4). Since that time, additional human and murine TLR proteins have been identified. Mammalian TLR proteins appear to represent a conserved family of innate immune recognition receptors.
T K, Means, D T, Golenbock, M J, Fenton
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Toll-like receptors in the skin

Seminars in Immunopathology, 2007
Toll-like receptors (TLRs) are important pattern-recognition receptors involved in host defense against a variety of pathogenic microorganisms. Activation of TLRs leads to the production of cytokines, chemokines, antimicrobial peptides, and upregulation costimulatory and adhesion molecules involved in innate and adaptive immune responses.
Lloyd S, Miller, Robert L, Modlin
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Toll-like receptors and sepsis

Current Infectious Disease Reports, 2004
Recent evidence suggests that Toll-like receptors (TLRs) play a major role in innate immunity to recognize specific molecular patterns derived from pathogens, including lipid, protein, DNA, and RNA, and to fight against pathogens. Each TLR displays a difference in the expression pattern, intracellular localization, and signaling pathway, resulting in ...
Ken J, Ishii, Shizuo, Akira
openaire   +2 more sources

Toll‐Like Receptors and Diabetes

Annals of the New York Academy of Sciences, 2008
Toll‐like receptors (TLRs) recognize molecular patterns relating to a variety of microbial infections. Stimulation through TLRs leads to activation of antigen‐presenting cells, production of inflammatory cytokines creating inflammation, and production of type 1 interferons (IFNs) that include IFN‐α and ‐β, and exerts direct effects on regulatory cells.
Wong, FS, Wen, L
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Toll-like receptors and the eye

Current Opinion in Allergy and Clinical Immunology, 2005
This review will describe the structure, expression/distribution and functional activity of Toll-like receptors, in particular in the ocular structures. It will also discuss innate and adaptive immune responses, by exploring the possible modulation/regulation of innate and adaptive immunity by Toll-like receptors, in view of recent findings observed in
Micera, Alessandra, Stampachiacchiere, Barbara, Aronni, Silvia, dos Santos, Myrna Serapiao, LAMBIASE, ALESSANDRO   +4 more
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Toll-Like Receptors in Dermatology

Dermatologic Clinics, 2007
The human skin represents the first line of defense against potentially hazardous environmental threats (ie, infection by microbes, such as viruses, bacteria, and fungi). To fulfill this crucial function and to maintain the integrity of the skin compartment, evolution has equipped the human immune system with a variety of sophisticated tools leading to
Martin, Mempel, Behnam Naderi, Kalali, Markus, Ollert, Johannes, Ring   +3 more
openaire   +2 more sources

Toll-Like Receptors and Their Ligands

2002
The Toll-like receptors (TLRs) are key molecules involved in the recognition of pathogens by the innate immune system. This family of germ line-encoded receptors has evolved to recognize conserved features of microbes. Currently, 10 TLR family members have been identified in mammals.
G M, Barton, R, Medzhitov
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Viruses and Toll-like receptors

Microbes and Infection, 2004
Production of inflammatory cytokines and type I interferons by mammalian cells is mediated through virus-specific activation of Toll-like receptors (TLRs). Known roles for different TLRs and speculation as to their roles in viral pathogenesis and immunity are discussed in this review.
Robert W, Finberg, Evelyn A, Kurt-Jones
openaire   +2 more sources