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Signalling of Toll-Like Receptors
2008Since Toll-like receptor (TLR) signaling was found crucial for the activation of innate and adaptive immunity, it has been the focus of immunological research. There are at least 13 identified mammalian TLRs, to date, that share similarities in their extracellular and intracellular domains.
Constantinos, Brikos, Luke A J, O'Neill
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Structure of Toll-Like Receptors
2008The ten human Toll-like receptors are able to respond to an extremely diverse range of microbial products ranging from di- and tri-acylated lipids to nucleic acids. An understanding of the molecular structure adopted by the receptor extracellular, transmembrane, and cytoplasmic domains and the way in which these structures interact with ligands and ...
Nicholas J, Gay, Monique, Gangloff
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Regulation of the nucleic acid-sensing Toll-like receptors
Nature Reviews Immunology, 2021Nicholas A Lind +2 more
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Epithelial Toll-like receptors and their role in gut homeostasis and disease
Nature Reviews Gastroenterology and Hepatology, 2020Juan F Burgueño +2 more
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Regulation of antigen presentation by Mycobacterium tuberculosis: a role for Toll-like receptors
Nature Reviews Microbiology, 2010Clifford V Harding +2 more
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Toll-like receptors and innate immunity
Biochemical and Biophysical Research Communications, 2009Himanshu Kumar, Shizuo Akira
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The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
Nature Immunology, 2010Taro Kawai, Shizuo Akira, Kawai Taro
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Toll-like receptors and chronic inflammation in rheumatic diseases: new developments
Nature Reviews Rheumatology, 2016Leo A B Joosten +2 more
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