Results 51 to 60 of about 381,354 (308)

Porphyromonas gingivalis lipopolysaccharide affects oral epithelial connections via pyroptosis

Journal of Dental Sciences, 2021
Background/purpose: Pyroptosis is a form of programmed cell death dependent on the activation of caspase-1. Porphyromonas gingivalis (P. gingivalis) is a major pathogenic bacterium in periodontitis and its lipopolysaccharide (LPS) can trigger ...
Yuyang Li, Baosheng Li, Yujie Liu, Haoyang Wang, Mengxiao He, Yanqun Liu, Yidan Sun, Weiyan Meng   +7 more
doaj   +1 more source

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

Multi‐Enzyme Mimetic Molybdenum Nitride Nanozymes Reshape Subgingival Microenvironment for Synergistic Periodontitis Therapy via ROS Regulation and Microbiome Remodeling

Advanced Science, EarlyView.
ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang, Zhongwei Yang, Yunfan Zhang, Longwei Wang, Xiaoyu Zhang, Jiahui Mao, Yizhi Dai, Yifan Yuan, Mingge Wang, Xin Yang, Xin Yu, Jing Liu, Chunying Chen   +12 more
wiley   +1 more source

Wear of human teeth: a tribological perspective [PDF]

, 2005
The four main types of wear in teeth are attrition (enamel-on-enamel contact), abrasion (wear due to abrasive particles in food or toothpaste), abfraction (cracking in enamel and subsequent material loss), and erosion (chemical decomposition of the tooth)
Amaechi B. T., Anderson D. J., Berkovitz B. K. B., Björn H., Björn H., Boyd A., Cooper W. E.G., De Long R., Every R. G., Lambrechts P., McCoy G., Morneburg T. R., Nohl F. S., Roulet J. F., Rudd K. D., Scott J. H., Tyldesley W. R., Vowles R. W., Øilo G.   +18 more
core   +2 more sources

Administration of Porphyromonas gingivalis in pregnant mice enhances glycolysis and histone lactylation/ADAM17 leading to cleft palate in offspring

International Journal of Oral Science
Periodontal disease is a risk factor for many systemic diseases such as Alzheimer’s disease and adverse pregnancy outcomes. Cleft palate (CP), the most common congenital craniofacial defect, has a multifaceted etiology influenced by complex genetic and ...
Xige Zhao, Xiaoyu Zheng, Yijia Wang, Jing Chen, Xiaotong Wang, Xia Peng, Dong Yuan, Ying Liu, Zhiwei Wang, Juan Du   +9 more
doaj   +1 more source

Myeloid‐Derived Grancalcin Promotes Periodontal Inflammation and Pathological Bone Remodeling in Periodontitis

Advanced Science, EarlyView.
Grancalcin (GCA), a myeloid‐derived protein, is enriched in gingival tissues of periodontitis patients and mouse models. Through interactions with CD44 and activation of MYH9, GCA promotes NF‐κB signaling and exacerbates periodontal inflammation and bone loss.
Min Zhou, Yao Xiao, Ziyue Xu, Chengyu Yang, Jiang Li, Ya Liu, Ping Yin   +6 more
wiley   +1 more source

Identifying and improving students' mental models of tooth decay [PDF]

, 2017
The aims of this study were to identify the initial mental models of tooth decay among a sample of 15-16 year-old Spanish students, and then to analyse changes in these models following the students’ participation in a teaching sequence on this topic ...
Franco-Mariscal, Antonio Joaquín
core  

The Relationships Between Fluoride Intake Levels and Fluorosis of Late‐Erupting Permanent Teeth [PDF]

, 2017
Objectives To examine the relationships between fluoride intake levels and fluorosis of late‐erupting permanent teeth. Methods The current study used information collected from 437 children in the longitudinal Iowa Fluoride Study.
Aasenden, Baelum, Beltran-Aguilar, Bhagavatula, Burt, Cruz-Orcutt, Dean, Dean, DenBesten, Haavikko, Hong, Hong, Ishii, Kroon, Kumar, Larsen, Larsen, Levy, Levy, Levy, Levy, Maguire, Manji, McClure, McClure, Nelson, Palenstein Helderman, Pendrys, Pendrys, Pendrys, Pendrys, Pendrys, Ramires, Russell, Rwenyonyi, Shillingburg, Singh, Slayton, Sudhir, Tai, Thylstrup, United States Department of Health and Human Services, Warren, Whitford   +43 more
core   +2 more sources

Advances in mesenchymal stem cell conditioned medium-mediated periodontal tissue regeneration

Journal of Translational Medicine, 2021
Periodontitis is a chronic inflammatory disease that leads to the destruction of both soft and hard periodontal tissues. Complete periodontal regeneration in clinics using the currently available treatment approaches is still a challenge.
Hongbing Lin, Huishan Chen, Xuetao Zhao, Zhen Chen, Peipei Zhang, Yue Tian, Yawei Wang, Tong Ding, Lijing Wang, Yuqin Shen   +9 more
doaj   +1 more source

Development and Structural Characterization of UTE‐156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase

Advanced Science, EarlyView.
The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo, Subramanya Hegde, Xuan Jia, Kimberly Coffman, Hariprasad Vankayalapati, David Bearss, Kevin B. Jones, Alex W. Stark, Peter S. Shen   +8 more
wiley   +1 more source