Results 1 to 10 of about 79,811 (267)
How enzymatic activity is involved in chromatin organization
eLife, 2022 Spatial organization of chromatin plays a critical role in genome regulation. Previously, various types of affinity mediators and enzymes have been attributed to regulate spatial organization of chromatin from a thermodynamics perspective.
Rakesh Das +4 more
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Life, 2022 Aeroplysinin-1 is a brominated isoxazoline alkaloid that has exhibited a potent antitumor cell effect in previous reports. We evaluated the cytotoxicity of aeroplysinin-1 against leukemia and prostate cancer cells in vitro. This marine alkaloid inhibited
Shou-Ping Shih +6 more
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Pathogens, 2021 In the last few years, increasing importance is attached to problems caused by fungal pathogens. Current methods of preventing fungal infections remain unsatisfactory.
Iwona Gabriel +3 more
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Current Protocols in Pharmacology, 2012 AbstractTopoisomerases are nuclear enzymes that play essential roles in DNA replication, transcription, chromosome segregation, and recombination. All cells have two major forms of topoisomerases: type I enzymes, which make single‐stranded cuts in DNA, and type II enzymes, which cut and pass double‐stranded DNA. DNA topoisomerases are important targets
John L, Nitiss +4 more
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The role of isoflavones in augmenting the effects of radiotherapy
Frontiers in Oncology, 2023 Cancer is one of the major health problems and the second cause of death worldwide behind heart disease. The traditional soy diet containing isoflavones, consumed by the Asian population in China and Japan has been identified as a protective factor from ...
Alesia Ivashkevich, Alesia Ivashkevich
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AFM studies of DNA structures extracted from adriamycin treated and non-treated Erlich tumor cells [PDF]
Journal of the Serbian Chemical Society, 2005 Atomic force microscopy (AFM), a unique tool to investigate drug treatment of cancer cells, was used to analyze the anti-neoplastic activity of adriamycin by comparing DNA structures of non-treated and adriamycin-treated Ehrlich tumor cells.
Avramov-Ivić M. +8 more
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Loss of TOP3B leads to increased R-loop formation and genome instability [PDF]
Open Biology, 2019 Topoisomerase III beta (TOP3B) is one of the least understood members of the topoisomerase family of proteins and remains enigmatic. Our recent data shed light on the function and relevance of TOP3B to disease.
Tao Zhang +5 more
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eLife, 2022 Type II topoisomerases modulate chromosome supercoiling, condensation, and catenation by moving one double-stranded DNA segment through a transient break in a second duplex.
Joshua Jeong +4 more
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DNA-Binding Anticancer Drugs: One Target, Two Actions
Molecules, 2021 Amsacrine, an anticancer drug first synthesised in 1970 by Professor Cain and colleagues, showed excellent preclinical activity and underwent clinical trial in 1978 under the auspices of the US National Cancer Institute, showing activity against acute ...
Bruce C. Baguley +3 more
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Bacterial Topoisomerases, Anti‐Topoisomerases, and Anti‐Topoisomerase Resistance [PDF]
Clinical Infectious Diseases, 1998 Topoisomerases are ubiquitous enzymes necessary for controlling the interlinking and twisting of DNA molecules. Among the four topoisomerases identified in eubacteria, two, DNA gyrase and topoisomerase IV have been exploited by nature and the pharmaceutical industry as antibacterial targets.
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