Results 171 to 180 of about 79,811 (267)

Processing of DNA Topoisomerase II-DNA-Protein Crosslinks Associated With Anticancer Drugs. [PDF]

Genes Cells
Sakasai R, Iwabuchi K.
europepmc   +1 more source

Assays for the Preferential Binding of Human Topoisomerase I to Supercoiled DNA

, 2009
Zheng Yang, James J. Champoux
openalex   +1 more source

Identification of prokineticin‐2 as potential pharmacodynamic biomarker for overcoming doxorubicin resistance in multicellular breast cancer spheroids

British Journal of Pharmacology, Volume 183, Issue 3, Page 491-504, February 2026.
Background and purpose Despite advances in immunotherapy, doxorubicin (Dox) chemotherapy is still the irreplaceable first‐line therapy for solid tumours such as breast cancer. However, chemotherapy resistance is the major limiting factor, requiring the use of high doses of Dox to achieve the anti‐tumour actions, often leading to severe side effects ...
Martina Vincenzi, Amin Kremic, Nathalie N. Tscheiller, Po‐Yen Hsu, Michael W. Y. Chan, Roberta Lattanzi, Canan G. Nebigil   +6 more
wiley   +1 more source

Mechanism-informed identification of FDA-approved topoisomerase inhibitors disrupting SARS-CoV-2 nucleocapsid-RNA interactions. [PDF]

BMC Chem
Zhang DW, Xu XS, Xu L, Xie L, Li Y, Chang S.   +5 more
europepmc   +1 more source

In vitro assays used to measure the activity of topoisomerases [PDF]

, 1990
J. Barrett, J.A. Sutcliffe, Thomas D. Gootz   +2 more
openalex   +1 more source

Regulation of R‐Loop Dynamics by Proteins and Long Noncoding RNAs: An Emerging Paradigm for Cancer Treatment

Cancer Science, Volume 117, Issue 2, Page 297-307, February 2026.
R‐loops are three‐stranded nucleic acid structures whose dysregulation leads to genomic instability and cancer progression. This review summarizes the protein and lncRNA machineries that regulate R‐loop dynamics and discusses the therapeutic potential of targeting these pathways in cancer.
Miho M. Suzuki, Keiko Shinjo, Tatsunori Nishimura, Yutaka Kondo   +3 more
wiley   +1 more source

Differential roles of type I topoisomerases in regulating HPV pathogenesis. [PDF]

Proc Natl Acad Sci U S A
Vats A, Templeton CW, Laimins L.
europepmc   +1 more source

Global diversification of coastal Cafius rove beetles (Coleoptera: Staphylinidae) driven by ocean currents since the early Miocene

Cladistics, Volume 42, Issue 1, Page 79-94, February 2026.
Abstract As our understanding of abiotic factors continues to grow, along with insights into the biological traits of organisms, so too does the sophistication of studies exploring global diversification and spatio‐temporal distribution patterns. The global distribution of coastal Cafius rove beetles, combined with the endemic distribution patterns ...
Kee‐Jeong Ahn, Jeong‐Hun Song
wiley   +1 more source

A convenient single-cell assay for the newly synthesized transcriptome reveals FLI1 regulon downregulation during T cell activation. [PDF]

Cell Rep Methods
Lyu J, Xu X, Chen C.
europepmc   +1 more source

The large subunit of Leishmania topoisomerase I functions as the ‘molecular steer’ in type IB topoisomerase [PDF]

, 2007
Somdeb BoseDasgupta, Agneyo Ganguly, Benu Brata Das, Amit Roy, Neeta V. M. Khalkho, Hemanta K. Majumder   +5 more
openalex   +1 more source