Results 11 to 20 of about 79,811 (267)

Synthesis and Biological Evaluation of Novel Indole-Derived Thioureas

Molecules, 2018
A series of 2-(1H-indol-3-yl)ethylthiourea derivatives were prepared by condensation of 2-(1H-indol-3-yl)ethanamine with appropriate aryl/alkylisothiocyanates in anhydrous media.
Giuseppina Sanna, Silvia Madeddu, Gabriele Giliberti, Sandra Piras, Marta Struga, Małgorzata Wrzosek, Grażyna Kubiak-Tomaszewska, Anna E. Koziol, Oleksandra Savchenko, Tadeusz Lis, Joanna Stefanska, Piotr Tomaszewski, Michał Skrzycki, Daniel Szulczyk   +13 more
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Ubiquitous Nature of Fluoroquinolones: The Oscillation between Antibacterial and Anticancer Activities

Antibiotics, 2017
Fluoroquinolones are synthetic antibacterial agents that stabilize the ternary complex of prokaryotic topoisomerase II enzymes (gyrase and Topo IV), leading to extensive DNA fragmentation and bacteria death.
Temilolu Idowu, Frank Schweizer
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Prospects of Topoisomerase Inhibitors as Promising Anti-Cancer Agents

Pharmaceuticals, 2023
Topoisomerases are very important enzymes that regulate DNA topology and are vital for biological actions like DNA replication, transcription, and repair. The emergence and spread of cancer has been intimately associated with topoisomerase dysregulation.
Prasanna Anjaneyulu Yakkala, Naveen Reddy Penumallu, Syed Shafi, Ahmed Kamal   +3 more
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FIRST RESULTS ABOUT TOPOISOMERASE ACTIVITY IN ASTACUS ASTACUS AND AUSTROPOTAMOBIUS PALLIPES AS A BIOMARKER FOR CRAYFISH VIABILITY

Knowledge and Management of Aquatic Ecosystems, 2004
A comparative study of topoisomerase activity in two European crayfish species Astacus astacus and Austropotamobius pallipes was carried out to determine the physiological basis of the difference in ecological fitness of these systematically related ...
PAOLUCCI M., DI CRISTO C., LIBERATO C., DI COSMO A.   +3 more
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Dynamics of chromosome organization in a minimal bacterial cell

Frontiers in Cell and Developmental Biology, 2023
Computational models of cells cannot be considered complete unless they include the most fundamental process of life, the replication and inheritance of genetic material.
Benjamin R. Gilbert, Zane R. Thornburg, Troy A. Brier, Jan A. Stevens, Fabian Grünewald, John E. Stone, John E. Stone, Siewert J. Marrink, Zaida Luthey-Schulten, Zaida Luthey-Schulten, Zaida Luthey-Schulten   +10 more
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THE ROLE OF EFFLUX PUMP AND OTHER MECHANISMS OF ANTIMICROBIAL RESISTANCE TO (FLUORO)QUINOLONES IN EPIDEMIC ISOLATES OF SALMONELLA TYPHIMURIUM, SALMONELLA KENTUCKY AND SALMONELLA INFANTIS

Archives of Veterinary Medicine, 2015
This paper briefly describes mechanisms of resistance to fluoroquinolones in several worldwide distributed Salmonella clones. The isolates have acquired multiple resistance traits over the years due to extensive antibiotic treatment both in human and ...
Marina Arnaut, Maja Velhner, Ljiljana Suvajdžić, Dubravka Milanov, Jelena Petrović, Gordana Kozoderović   +5 more
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Structures of topoisomerase V in complex with DNA reveal unusual DNA-binding mode and novel relaxation mechanism

eLife, 2022
Topoisomerase V is a unique topoisomerase that combines DNA repair and topoisomerase activities. The enzyme has an unusual arrangement, with a small topoisomerase domain followed by 12 tandem (HhH)2 domains, which include 3 AP lyase repair domains.
Amy Osterman, Alfonso Mondragón
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Amsacrine Derivatives Selectively Inhibit Mycobacterial Topoisomerase I (TopA), Impair M. smegmatis Growth and Disturb Chromosome Replication

Frontiers in Microbiology, 2018
Amsacrine, which inhibits eukaryotic type II topoisomerase via DNA intercalation and stabilization of the cleavable topoisomerase-DNA complex, promotes DNA damage and eventually cell death.
Marcin J. Szafran, Marta Kołodziej, Patrycja Skut, Brahmam Medapi, Agnieszka Domagała, Damian Trojanowski, Jolanta Zakrzewska-Czerwińska, Jolanta Zakrzewska-Czerwińska, Dharmarajan Sriram, Dagmara Jakimowicz, Dagmara Jakimowicz   +10 more
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Developments in Non-Intercalating Bacterial Topoisomerase Inhibitors: Allosteric and ATPase Inhibitors of DNA Gyrase and Topoisomerase IV

Pharmaceuticals, 2023
Increases in antibiotic usage and antimicrobial resistance occurrence have caused a dramatic reduction in the effectiveness of many frontline antimicrobial treatments.
Scott Grossman, Colin W. G. Fishwick, Martin J. McPhillie   +2 more
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MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA

Biology Open, 2012
Summary Topoisomerase II creates a double-strand break intermediate with topoisomerase covalently coupled to the DNA via a 5′-phosphotyrosyl bond. These intermediate complexes can become cytotoxic protein-DNA adducts and DSB repair at these lesions ...
Ka Cheong Lee, Kay Padget, Hannah Curtis, Ian G. Cowell, Davide Moiani, Zbyslaw Sondka, Nicholas J. Morris, Graham H. Jackson, Simon J. Cockell, John A. Tainer, Caroline A. Austin   +10 more
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