Results 11 to 20 of about 67,641 (348)
Bioessays, 2021 DNA topoisomerases, capable of manipulating DNA topology, are ubiquitous and indispensable for cellular survival due to the numerous roles they play during DNA metabolism.
Shannon J. McKie, K. Neuman, A. Maxwell
semanticscholar +1 more source
Inhibition of Topoisomerases by Metal Thiosemicarbazone Complexes
International Journal of Molecular Sciences, 2023 Topoisomerases, common targets for anti-cancer therapeutics, are crucial enzymes for DNA replication, transcription, and many other aspects of DNA metabolism. The potential anti-cancer effects of thiosemicarbazones (TSC) and metal–TSC complexes have been
Xiaohua Jiang +5 more
semanticscholar +1 more source
mSystems, 2021 Bacterial gene expression is controlled at multiple levels, with chromosome supercoiling being one of the most global regulators. Global DNA supercoiling is maintained by the orchestrated action of topoisomerases.
Martyna Gongerowska-Jac +8 more
doaj +1 more source
Dual Targeting Topoisomerase/G-Quadruplex Agents in Cancer Therapy—An Overview
Biomedicines, 2022 Topoisomerase (Topo) inhibitors have long been known as clinically effective drugs, while G-quadruplex (G4)-targeting compounds are emerging as a promising new strategy to target tumor cells and could support personalized treatment approaches in the near
Silvia Salerno +5 more
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Current Protocols in Pharmacology, 2012 AbstractTopoisomerases are nuclear enzymes that play essential roles in DNA replication, transcription, chromosome segregation, and recombination. All cells have two major forms of topoisomerases: type I enzymes, which make single‐stranded cuts in DNA, and type II enzymes, which cut and pass double‐stranded DNA. DNA topoisomerases are important targets
John L, Nitiss +4 more
openaire +2 more sources
DNA Topoisomerases Are Required for Preinitiation Complex Assembly during GAL Gene Activation. [PDF]
PLoS ONE, 2015 To investigate the importance of topoisomerases for transcription of the galactose induced genes, we have studied the expression of GAL1, GAL2, GAL7 and GAL10 in Saccharomyces cerevisiae cells deficient for topoisomerases I and II.
Morten Roedgaard +4 more
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Diversity and Functions of Type II Topoisomerases
Acta Naturae, 2021 The DNA double helix provides a simple and elegant way to store and copy genetic information. However, the processes requiring the DNA helix strands separation, such as transcription and replication, induce a topological side-effect – supercoiling of the
Dmitry Sutormin +5 more
semanticscholar +1 more source
Transcription facilitated genome-wide recruitment of topoisomerase I and DNA gyrase. [PDF]
PLoS Genetics, 2017 Movement of the transcription machinery along a template alters DNA topology resulting in the accumulation of supercoils in DNA. The positive supercoils generated ahead of transcribing RNA polymerase (RNAP) and the negative supercoils accumulating behind
Wareed Ahmed +5 more
doaj +1 more source
Unravelling the mechanisms of Type 1A topoisomerases using single-molecule approaches
Nucleic Acids Research, 2021 Topoisomerases are essential enzymes that regulate DNA topology. Type 1A family topoisomerases are found in nearly all living organisms and are unique in that they require single-stranded (ss)DNA for activity.
Dian Spakman +5 more
semanticscholar +1 more source
Copper Complexes as Anticancer Agents Targeting Topoisomerases I and II
Cancers, 2020 Simple Summary Organometallics, such as copper compounds, are cancer chemotherapeutics used alone or in combination with other drugs. One small group of copper complexes exerts an effective inhibitory action on topoisomerases, which participate in the ...
Caroline Molinaro +3 more
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