Results 91 to 100 of about 2,244 (195)

On the Stability of Zwitterions of Pyridine Sulfonylureas: The Effect of Isosterism, Acidity, and Microsolvation

, 2014
Pyridine sulfonylureas (PSUs) are known to exist in zwitterionic form in the solid phase. For example, torsemide, a diuretic drug, exists in three polymorphic forms: two of them in the zwitterionic state and one in the “partial zwitterionic” state ...
Dhaked, Devendra K., Bharatam, Prasad V., Devendra K. Dhaked, Prasad V. Bharatam   +3 more
core   +1 more source

A double-blind randomized crossover trial of two loop diuretics in chronic kidney disease

, 2003
A double-blind randomized crossover trial of two loop diuretics in chronic kidney disease.BackgroundTorsemide has predictable absorption compared to furosemide. Thereby, torsemide results in more constant exposure to active drug.
Vasavada, Nina, Saha, Chandan, Agarwal, Rajiv, Chandan Saha, Rajiv Agarwal, Nina Vasavada   +5 more
core   +1 more source

Impact of mineralocorticoid receptor polymorphisms on urinary electrolyte excretion with and without diuretic drugs

, 2015
Aim: Polymorphisms in the mineralocorticoid receptor may affect urinary sodium and potassium excretion. We investigated polymorphisms in the MR gene in relation to urinary electrolyte excretion in two separate studies.
Schirmer, Markus, Tzvetkov, Mladen Vassilev, Vormfelde, Stefan Viktor, Brockmoeller, Juergen, Haubrock, Martin, Dalila, Nawar   +5 more
core   +1 more source

Effects of Torsemide on Pharmacodynamics and Pharmacokinetics of Warfarin

, 2012
연구 목표 본 연구는 항응고제인 warfarin과 함께 병용되어지는 이뇨제 torsemide가 warfarin의 약물동력학적, 약물동태학적 측면에 미치는 영향을 조사하여 안전하고 효과적인 항응고 치료를 유지하는데 기여하고자 하였다. 또한 한국인 인공심장판막치환환자에서 유전적 다형성을 포함한 이뇨제의 사용여부가 warfarin의 유지용량에 미치는 영향을 평가함으로써 최적의 항응고 치료에 기여하고자 하였다.
김한올
core   +1 more source

Dynamic changes and clinical significance of the gut microbiota and serum metabolites in breast cancer onset, progression and chemotherapy intervention

Frontiers in Oncology
ObjectiveAlterations of the gut microbiota and host metabolic reprogramming are closely associated with the development of breast cancer and the treatment response; however, integrated studies of the gut microbiota and metabolome spanning the transition ...
Shuyun Jiang, Zhanwei Du, Yufei Wang, Hongwei Ma, Zhijun Ma, Xiaowang Wang   +5 more
doaj   +1 more source

On-treatment analysis of torsemide versus furosemide for patients hospitalized for heart failure: A post-hoc analysis of TRANSFORM-HF

AimThe TRANSFORM-HF trial demonstrated no significant outcome differences between torsemide and furosemide following hospitalization for heart failure (HF), but may have been impacted by non-adherence to the randomized diuretic.
Velazquez, Eric J., Ketema, Fassil, Goyal, Parag, Greene, Stephen J., Ambrosy, Andrew P., Wojdyla, Daniel M., Kim, Dong-Yun, Skopicki, Hal A., Mentz, Robert J., Anstrom, Kevin J., Desvigne-Nickens, Patrice, Clare, Robert M., Kittipibul, Veraprapas, Eisenstein, Eric L., Pitt, Bertram   +14 more
core   +1 more source

Determination of the levels of brain natriuretic peptide and its N-terminal fragment for the evaluation of the efficiency of renal replacement therapy modalities in patients with decompensated chronic heart failure

Терапевтический архив, 2010
Aim: to compare the capabilities of identifying different types of brain natriuretic peptide (BNP) for the evaluation of renal replacement therapy modalities in patients with decompensated chronic heart failure (CHF). Subjects and methods.
E A Tabakyan, A Yu Zaruba, A N Rogoza, D M Ataullakhanova, V V Kukharchuk   +4 more
doaj  

Impact of baseline kidney dysfunction on oral diuretic efficacy following hospitalization for heart failure – insights from TRANSFORM-HF

AimAmong patients discharged after hospitalization for heart failure (HF), a strategy of torsemide versus furosemide showed no difference in all-cause mortality or hospitalization. Clinicians have traditionally favoured torsemide in the setting of kidney
Martens, Pieter, Velazquez, Eric J., Ketema, Fassil, Anstrom, Kevin, Hall, Michael E., Greene, Stephen J., Li, Shuang, Fang, James C., Kim, Dong-Yun, Mentz, Robert J., Tang, W.H. Wilson, Kapelios, Chris J., Wojdyla, Daniel, Eisenstein, Eric L., Pitt, Bertram, Mullens, Wilfried   +15 more
core   +1 more source

Comparative effectiveness of torsemide vs furosemide in the management of heart failure patients: Win-ratio reanalysis of the TRANSFORM-HF trial. [PDF]

Am Heart J
Tong G, Zeng Y, Greene SJ, Anstrom KJ, Testani J, Mentz RJ, Li F, Velazquez EJ.   +7 more
europepmc   +1 more source

3-Dimensional Human iPSC-Derived Cardiac Organoids for Antifibrotic Drug Screening. [PDF]

Circ Res
Zhang H, Huang R, Thai PN, Ren L, Shivnaraine RV, Zhu W, Dai Y, Liu W, Xie M, Liu X, Tan R, Yang X, Cao X, Wu X, Wu MA, Caridi C, Solow-Cordero D, Wu JC.   +17 more
europepmc   +1 more source