Results 111 to 120 of about 43,554 (293)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Efficient self-stabilizing algorithms for minimal total k-dominating sets in graphs
, 2014 International audienceWe propose the first polynomial self-stabilizing distributed algorithm for the minimal total dominating set problem in an arbitrary graph.
Kheddouci, Hamamache +2 more
core +3 more sources
Maximum Number of Minimum Dominating and Minimum Total Dominating Sets
, 2013 6 ...
Godbole, Anant +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
On the Total k-Domination in Graphs
Discussiones Mathematicae Graph Theory, 2018 Let G = (V, E) be a graph; a set S ⊆ V is a total k-dominating set if every vertex v ∈ V has at least k neighbors in S. The total k-domination number γkt(G) is the minimum cardinality among all total k-dominating sets.
Bermudo Sergio +2 more
doaj +1 more source
Structure of the set of all minimal total dominating functions of some classes of graphs
, 2010 In this paper we study some of the structural properties of the set of all minimal total dominating functions ($_T$) of cycles and paths and introduce the idea of function reducible graphs and function separable graphs.
MacGillivray, Gary, Kumar, K.
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Domination parameters of a graph with added vertex [PDF]
Opuscula Mathematica, 2004 Let \(G=(V,E)\) be a graph. A subset \(D\subseteq V\) is a total dominating set of \(G\) if for every vertex \(y\in V\) there is a vertex \(x\in D\) with \(xy\in E\).
Maciej Zwierzchowski
doaj