Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Disjunctive total domination in some tree networks
, 2021 Vecdi Aytaç, Tufan Turacı
openalex +2 more sources
Total Roman {3}-Domination: The Complexity and Linear-Time Algorithm for Trees [PDF]
, 2021 Xinyue Liu +3 more
openalex +1 more source
Domination parameters with number 2: interrelations and algorithmic consequences
, 2016 In this paper, we study the most basic domination invariants in graphs, in which number 2 is intrinsic part of their definitions. We classify them upon three criteria, two of which give the following previously studied invariants: the weak $2$-domination
Bonomo, Flavia +4 more
core
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
Graphs whose vertex set can be partitioned into a total dominating set and an independent dominating set [PDF]
Opuscula MathematicaA graph \(G\) whose vertex set can be partitioned into a total dominating set and an independent dominating set is called a TI-graph. We give constructions that yield infinite families of graphs that are TI-graphs, as well as constructions that yield ...
Teresa W. Haynes, Michael A. Henning
doaj +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Algorithmic aspect on total Roman {2}-domination of Cartesian products of paths and cycles [PDF]
, 2023 Qin Chen
openalex +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source