Results 71 to 80 of about 7,071,056 (303)

A BSCB‐Penetrating Nanoplatform for Enhanced Luteolin Delivery in PRMT2‐Targeted Epigenetic Therapy of Spinal Cord Injury

Advanced Science, EarlyView.
In this work, MSN‐BO@LUT penetrates the blood‐spinal cord barrier for luteolin delivery in spinal cord injury. The nanodrug suppresses neuroinflammation and promotes functional recovery of the spinal cord. Mechanistically, luteolin targets protein arginine N‐methyltransferase (PRMT2) to decrease toll‐like receptor 4 (TLR4) methylation, thereby ...
Yixuan Wang, Bo Jin, Shipian Li, Qianxi Ouyang, Yu Xiao, Jiaxin Wen, Yehua Lai, Ping Wang, Yongjun Wang, Xuejun Cui, Weian Zhang, Min Yao   +11 more
wiley   +1 more source

Extraction and purification of total flavonoids from Zanthoxylum planispinum Var. Dintanensis leaves and effect of altitude on total flavonoids content

Scientific Reports
To investigate the impact of varying altitudes on the functional components of the leaves of Zanthoxylum planispinum var. Dintanensis, this research collected leaf samples from three different elevations: 610 m, 833 m, and 1083 m. Utilizing water and ethanol as extraction solvents, the study optimized extraction parameters via an ultrasonic-assisted ...
Jiyue Wang, Xianqi Huang, Zhenyu Chen, Nian Chen, Mingli Yang, Chenggang Liang, Yanghua Yu, Denghong Shi   +7 more
openaire   +3 more sources

PENETAPAN KADAR FLAVONOID TOTAL DAN FENOLIK TOTAL PADA EKSTRAK ETANOL 70% DAUN KUBIS (Brassica oleracea L.) DENGAN METODE EKSTRAKSI ULTRASONIK [PDF]

, 2020
Penelitian ini bertujuan untuk menetapkan kadar fenol total dan flavonoid total pada ekstrak kubis.Ekstrak kubis didapatkan dengan cara metode ultrasonik menggunakan pelarut etanol 70%.
Supriatna, Bagus, Sjahid, Landyyun Rahmawan, Sediarso, Sediarso   +2 more
core  

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source

Tyrosinase Inhibitory Activity of Methanolic Extract and Fractions from Green Seaweed Ulva lactuca

Squalen
Ulva lactuca, a widely available green seaweed, has demonstrated promising bioactivity as a tyrosinase inhibitor. This study aimed to evaluate the tyrosinase inhibitory activity of U. lactuca extracts and identify the active compounds responsible.
Mohamad Gazali, Fazidatul Lu’luil Maknun, Amir Husni, Nurjanah Nurjanah, Muhammad Nursid, Uswatun Hasanah, Zuriat Zuriat, Rina Syafitri   +7 more
doaj   +1 more source

Developing Highly Effective Nanoparticle mRNA Therapeutic for Pediatric Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Sepsis‑induced pediatric acute respiratory distress syndrome suppresses FOXF1 in lung endothelial cells which causes life‐threatening lung damage. To counter this, researchers developed nanoparticles that specifically target these cells and deliver FOXF1 mRNA.
Zicheng Deng, Wen Gao, Jonathan Do, Danli Lu, Ying‐Wei Lan, Andreas Damianos, Gautam Verma, Ali Al Siraj, Isabella Lowry, Lance Peter, Nicholas E. Banovich, Fei Sun, Hua He, Tanya V. Kalin, Vladimir V. Kalinichenko   +14 more
wiley   +1 more source

Penentuan Kandungan Flavonoid, Fenolik, dan Antioksidan Total dari Akar, Batang, serta Daun Tanaman Miana (Coleus sp.) [PDF]

, 2023
Pengobatan penyakit menggunakan tumbuhan obat tradisional telah dikenal masyarakat Indonesia sejak zaman dahulu, salah satunya tanaman Miana (Coleus sp.). Miana berasal dari famili Lamiaceae, yang memiliki sifat antioksidan.
Widya, Anggraini
core   +1 more source

Total Phenolic, Total Flavonoids, Antioxidant and Antimicrobial Activities of Scrophularia Striata Boiss Extracts [PDF]

Jundishapur Journal of Natural Pharmaceutical Products, 2013
Scrophularia striata (Scrophulariaceae family) is an herbaceous plant that is traditionally used for treatment of microbial infections.Antimicrobial and antioxidant activity of different extracts (methanolic, ethanolic, aqueous and ethyl acetate) from S. striata aerial parts was evaluated.The antimicrobial activity of different extracts from S. striata
Mohaddese, Mahboubi, Nastaran, Kazempour, Ali Reza, Boland Nazar   +2 more
openaire   +3 more sources

Plant Metabolites Screening Identifies 7‐epi‐10‐Deacetyltaxol Inhibiting Cell Division by Interfering With the Cell Cycle and Microtubule Organization

Advanced Science, EarlyView.
In this study, an efficient screening system is developed for plant metabolites to find a compound, 7‐epi‐10‐deacetyltaxol, inhibits tissue elongation. It suppresses plant growth through brassinosteroid and microtubule pathways. It is later applied to animal cells and human tumor organoids, resulting in similar cell division suppression. These findings
Yan‐Jie Zhang, Yu‐Xuan Bai, Geng G. Tian, Bin Zhang, Ding‐Yi Lu, Qing‐Ping Yao, Wen‐Hao Tian, Xiao‐Na Wei, Jing‐Ting Yang, Ze‐Yu Xiong, Yi Lu, Yu‐Tong Jiang, Chun‐Hui Cai, Yu‐Ming Lu, Xian‐Qing Jia, Li‐Li Jing, Bao‐Jun Yang, Ying‐Xin Qi, Xin‐Xin Han, Ji Wu, Wen‐Hui Lin   +20 more
wiley   +1 more source

Polyphenolic Content and Antioxidant Activity of Aerial Parts of Four Turkish Medicinal Plants

Cumhuriyet Science Journal
The objective of this study was to investigate the total phenolic and flavonoid content, antioxidant capacity, and radical scavenging activity of endemic plants: Allium scorodoprasum L. subsp. rotundum (L.) Stearn, Consolida Orientalis (J.
Ayşe Hanbeyoğlu
doaj   +1 more source