Results 41 to 50 of about 558 (154)

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Dose dependence of the spectral characteristics of sigma-delta analog-to-digital converters

Безопасность информационных технологий, 2023
This paper presents the results of the study of sigma-delta analog-to-digital converters` main spectral parameters` dependence on the total ionizing dose (TID). Within the framework of this study the main parameters of analog-to-digital converters (ADC) (
Maria O. Kalashnikova, Roman S. Torshin, Georgy S. Sorokoumov, Alexander A. Demidov, Dmitry V. Boychenko   +4 more
doaj   +1 more source

Gabapentinoids‐duloxetine combination therapy for chronic pain: A mechanism oriented rational to bridge theoretical knowledge and real life setting

British Journal of Clinical Pharmacology, EarlyView.
Chronic pain represents a complex debilitating condition that extends beyond the protective function of physiological pain, often persisting as an independent disease entity. Chronic primary and secondary pain syndromes reflect a multifaceted continuum involving nociceptive, neuropathic and nociplastic mechanisms.
Stefania Nobili, Maurizio Evangelista, Elena Lucarini, Elena G. Giugliano, Carla Ghelardini, Laura Micheli, Lorenzo Di Cesare Mannelli   +6 more
wiley   +1 more source

The Analysis on Space Radiation Environment and Effect of the KOMPSAT-2 Spacecraft(I): Total Ionizing Dose Effect [PDF]

Journal of Astronomy and Space Sciences, 2001
In this paper, space radiation environment and total ionizing dose(TID) effect have been analyzed for the KOMPSAT-2 operational orbit. It has been revealed that the trapped protons are concentrated in the SAA(South Atlantic Anomaly) area and that the ...
Myung-Jin Baek, Hak-Jung Kim
doaj  

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). II. Treatments in more advanced clinical development

Epilepsia, EarlyView.
Abstract This article summarizes data for 13 investigational treatments for which at least preliminary seizure outcome data in patients with epilepsy were reported at the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices held in Madrid, Spain, on May 3–6, 2026.
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). I. Treatments in preclinical and early clinical development

Epilepsia, EarlyView.
Abstract Over the last 34 years, the Eilat Conference on New Antiepileptic Drugs and Devices has provided an interactive forum for stakeholders to discuss investigational and recently licensed treatments for seizures and epilepsy. The Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII) took place in Madrid, Spain, on May 3 ...
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

Radiation-Induced Degradation of a Cold-Redundant DC/DC Converter Under Total Ionizing Dose Stress

Micromachines
This paper investigates the degradation characteristics of a DC/DC converter operating under cold redundancy conditions when subjected to total ionizing dose (TID) effects.
Xiaojin Lu, Zhujun Xi, Qifeng He, Ziyu Zhou, Mengyao Li, Liangyu Xia, Gang Dong   +6 more
doaj   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Towards defining a simplified procedure for COTS system-on-chip TID testing

Nuclear Engineering and Technology, 2018
The use of System-on-Chip (SoC) solutions in the design of on-board data handling systems is an important step towards further miniaturization in space.
Stefano Di Mascio, Alessandra Menicucci, Gianluca Furano, Tomasz Szewczyk, Luigi Campajola, Francesco Di Capua, Andrea Lucaroni, Marco Ottavi   +7 more
doaj   +1 more source

Is Capsaicin Effective in Relieving the Symptoms of Burning Mouth Syndrome? A Systematic Review

Journal of Oral Rehabilitation, EarlyView.
The capsaicin, administered topically or systemically, reduces pain symptoms in patients with Burning Mouth Syndrome (BMS). However, despite consistent clinical improvement, the current evidence is limited and of low certainty, highlighting the need for well‐designed studies to confirm its effectiveness. ABSTRACT Background Burning Mouth Syndrome (BMS)
Ana Paula de Andrade Silva, Ian Wesley Rocha dos Santos, Zuleni Alexandre da Silva, Deborah Ribeiro Frazão, José Mário Matos‐Sousa, Wallacy Watson Pereira Melo, Rafael Rodrigues Lima, Renata Duarte de Souza‐Rodrigues   +7 more
wiley   +1 more source