Results 41 to 50 of about 554 (150)

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Dose dependence of the spectral characteristics of sigma-delta analog-to-digital converters

Безопасность информационных технологий, 2023
This paper presents the results of the study of sigma-delta analog-to-digital converters` main spectral parameters` dependence on the total ionizing dose (TID). Within the framework of this study the main parameters of analog-to-digital converters (ADC) (
Maria O. Kalashnikova, Roman S. Torshin, Georgy S. Sorokoumov, Alexander A. Demidov, Dmitry V. Boychenko   +4 more
doaj   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Effect of carbamazepine on the pharmacokinetics of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader, in healthy adults

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2183-2192, July 2026.
Aim To evaluate the effects of carbamazepine, a strong cytochrome P450 (CYP)3A4 inducer, on the pharmacokinetics and safety of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader. Methods This was a phase 1, open‐label, fixed‐sequence, two‐period study in healthy adult participants.
Hechuan Wang, Jennifer A. Winton, Kyle T. Matschke, Alexandre Stouffs, Kimberly C. Lee, Yuanyuan Zhang, Wenlian Qiao, Weiwei Tan   +7 more
wiley   +1 more source

The Analysis on Space Radiation Environment and Effect of the KOMPSAT-2 Spacecraft(I): Total Ionizing Dose Effect [PDF]

Journal of Astronomy and Space Sciences, 2001
In this paper, space radiation environment and total ionizing dose(TID) effect have been analyzed for the KOMPSAT-2 operational orbit. It has been revealed that the trapped protons are concentrated in the SAA(South Atlantic Anomaly) area and that the ...
Myung-Jin Baek, Hak-Jung Kim
doaj  

Proton‐Radiation Hardening of High‐Speed Ge/Si Integrated Photodetectors for Space Applications

Nanophotonics, Volume 15, Issue 12, 25 June 2026.
Hydrogen loading is demonstrated as a radiation‐hardening strategy for high‐speed Ge/Si integrated photodetectors under broadband proton irradiation. By suppressing irradiation‐induced leakage‐current growth and mitigating bandwidth degradation, hydrogen‐loaded devices maintain high‐speed operation and improved stability, providing a practical route ...
Junguo Xu, Yingying Zhong, Xiongping Bao, Junfeng Chen, Wenjie Peng, Haotian Hu, Yiti Xiong, Weiye Xia, Xiao Chen, Meisong Liao, Jianhui Bin, Yuchen Wang, Libing Zhou, Weibiao Chen   +13 more
wiley   +1 more source

Consensus on the Clinical Use of Pregabalin in Peripheral Neuropathic Pain

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Pregabalin, a second‐generation α2δ calcium‐channel ligand, exerts potent analgesic effects in peripheral neuropathic pain by reducing calcium influx, suppressing excitatory neurotransmitter release, and decreasing neuronal hyperexcitability. Based on a PRISMA‐guided review of 139 studies and multidisciplinary expert consensus, pregabalin demonstrates ...
Hui Lu, Yuefeng Rao, Jian Wang, Wan Shuanglin, Du Dongping, Ma Ke, Zhiying Feng, Suming Tian, Weidong Qiu, Xu Jing, Zhongwei zhao, Zhenhua Zeng, Benyan Luo, Changqing Wang, Hui Zhao, Kaiming Liu, Li Lin, Xianfeng Zhang, Gong Liyan, Haiqi Lu, Yan Liu, Qingwei Zhao, Yihe Hu   +22 more
wiley   +1 more source

Towards defining a simplified procedure for COTS system-on-chip TID testing

Nuclear Engineering and Technology, 2018
The use of System-on-Chip (SoC) solutions in the design of on-board data handling systems is an important step towards further miniaturization in space.
Stefano Di Mascio, Alessandra Menicucci, Gianluca Furano, Tomasz Szewczyk, Luigi Campajola, Francesco Di Capua, Andrea Lucaroni, Marco Ottavi   +7 more
doaj   +1 more source

Reproxalap ‐ A Novel Treatment Option for Allergic Conjunctivitis – A Comprehensive Narrative Review

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Allergic conjunctivitis is a prevalent, immune‐mediated hypersensitivity disorder of the ocular surface affecting 10%–20% of the global population. Current therapeutic options, while effective to some extent, are often limited by side effects and inconsistent efficacy.
Sanila Mughal, Roshanay Ejaz Awan, Hur Abbas, Zahra Sania, Ashna Habib, Syeda Kaneez Sakina, Amina Mahmud, Mohammed Mahmmoud Fadelallah Eljack   +7 more
wiley   +1 more source

Atomically Thin Sn:GaN‐GaN Homojunction for High‐Sensitivity β‐Ray Detection

Rare Metals, Volume 45, Issue 6, June 2026.
ABSTRACT Gallium nitride (GaN), a third‐generation wide‐bandgap semiconductor renowned for its superior radiation tolerance, holds promise for advanced β‐ray detection. Herein, a scalable liquid metal‐assisted in situ synthesis method is presented to fabricate Sn‐doped GaN homojunctions via gallium oxide printing followed by ammonolysis, enabling ...
Weiqing Liu, Wenrong Fan, Zhangwei Xue, Mingyu Li, Yong Shi, Xiaowei Li, Lu Zhang, Chen Su, Jianxiong Shao   +8 more
wiley   +1 more source