Results 191 to 200 of about 14,944,148 (406)

Bisbenzylisoquinoline Alkaloids and Related Compounds. IX. A Modified Total Synthesis of Stereoisomeric Mixture of Magnolamine : Studies on the Syntheses of Heterocyclic Compounds. CXLV.

, 1966
Tetsuji Kametani, Haruhiko Yagi, Shigeo Kaneda   +2 more
openalex   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

4-Step Total Synthesis of (−)-Pavidolide B [PDF]

, 2020
Yaoqiu Zhu, Elkin L. Romero, K. Srinivas, Elizabeth Noriega   +3 more
openalex   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Stereoselective total synthesis and enantioselective formal synthesis of the antineoplastic sesquiterpene quinone metachromin A

Journal of the Brazilian Chemical Society, 1999
The first total synthesis of the antineoplastic marine natural product metachromin-A (1) was accomplished through a convergent synthetic approach amenable to the preparation of analogues for biological studies.
Almeida Wanda P., Correia Carlos Roque D.   +1 more
doaj  

Total Synthesis of Manzacidins [PDF]

博士(理学 ...
難波, 康祐
core  

Total Synthesis of Laulimalide: Synthesis of the Northern and Southern Fragments

, 2012
Barry M. Trost, W. Michael Seganish, Cheol K. Chung, Dominique Amans   +3 more
openalex   +2 more sources

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source

Engineering of Bacillus subtilis for Enhanced Total Synthesis of Folic Acid

, 2005
Tao Zhu, Zhiwei Pan, Nathan Domagalski, Richard R. Koepsel, Mohammad M. Ataai, Michael M. Domach   +5 more
openalex   +1 more source

An Efficient Total Synthesis of Decarestrictine D [PDF]

, 2008
Priti Gupta, Pradeep Kumar
openalex   +1 more source