Results 181 to 190 of about 1,840,129 (319)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Asymmetric Total Synthesis of (-)-Verrucarol. [PDF]

Angew Chem Int Ed Engl
Powers MH, McCleerey JF, Bacon JW, McNeely J, Zhang W, Porco JA.   +5 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Total Synthesis of Eutyscoparol A and Violaceoid C

The first total synthesis of eutyscoparol A and total synthesis of violaceoid C via violaceoid A, have been accomplished including the improved total syntheses of violaceoid A and violaceoid B.
Teppei, Kuboki, Ayana, Shimauchi, Hisazumi, Tsutsui, Shotaro, Taguchi, Takatsugu, Murata, Yukiho, Kosaka, Shou, Tsugawa, Takumi, Yoshida, Takuto, Iwayama, Isamu, Shiina   +9 more
core   +1 more source

Total Synthesis of Scandine. [PDF]

JACS Au
Kitamura T, Morita K, Umekubo N, Yokoshima S.   +3 more
europepmc   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Bidirectional total synthesis of dimeric brevianamide alkaloids

The dimeric brevianamides are a unique collection of bioactive, alkaloid dimers that contain a pair of proline-tryptophan diketopiperazines. Unlike many other dimeric natural products with this moiety, the dimeric linkage in the brevianamides is ...
Lockyer, Adam Raymond
core   +1 more source

Bioinspired total synthesis of (+)-pleuromutilin. [PDF]

Nat Commun
Hua S, Zhong W, Chen L, Jia Y.
europepmc   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Advances in the Total Synthesis of Dihydrolycolucine

, 2010
Dihydrolycolucine is a Lycopodium alkaloid that has gained attention over the recent years due to its complex architecture and potential medicinal value.
Cash, Brandon Michael
core