Results 181 to 190 of about 10,668,490 (318)

Asymmetric Total Synthesis of (+)-Ineleganolide. [PDF]

Angew Chem Int Ed Engl
Han C, Zhang Y, Tian Y, Ding Z, Pan Z, Li J, Ren W.   +6 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Total Synthesis of (+)-CC-1065. [PDF]

J Am Chem Soc
Senzer BD, Danheiser RL.
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Corrigendum: Synthesis, characterization, and computational evaluation of some synthesized xanthone derivatives: focus on kinase target network and biomedical properties

Frontiers in Pharmacology
Wisam Taher Muslim, Layth Jasim Mohammad, Munaf M. Naji, Isaac Karimi, Matheel D. Al-Sabti, Majid Jabir, Mazin A. A. Najm, Helgi B. Schiöth   +7 more
doaj   +1 more source

Formal Total Synthesis of (±)-Isoalantolactone. [PDF]

Org Lett
Olsson W, Wennerberg J, Clementson S.
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Total Synthesis and Biological Evaluation of Exiguamines. [PDF]

JACS Au
Noh S, Park J, Kim Y, Krishnamurthy VR, Min CK, Choi EY, Lee C.   +6 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Bidirectional total synthesis of dimeric brevianamide alkaloids

The dimeric brevianamides are a unique collection of bioactive, alkaloid dimers that contain a pair of proline-tryptophan diketopiperazines. Unlike many other dimeric natural products with this moiety, the dimeric linkage in the brevianamides is ...
Lockyer, Adam Raymond
core   +1 more source