Results 191 to 200 of about 10,668,490 (318)

Asymmetric Total Synthesis of (-)-Verrucarol. [PDF]

Angew Chem Int Ed Engl
Powers MH, McCleerey JF, Bacon JW, McNeely J, Zhang W, Porco JA.   +5 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Total Synthesis and Antimalarial Studies of Caelestines A-C. [PDF]

ChemMedChem
Smith HST, Lock AM, Avery VM, Davis RA.
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Advances in the Total Synthesis of Dihydrolycolucine

, 2010
Dihydrolycolucine is a Lycopodium alkaloid that has gained attention over the recent years due to its complex architecture and potential medicinal value.
Cash, Brandon Michael
core  

Correction: Synthesis of highly substituted fluorenones via metal-free TBHP-promoted oxidative cyclization of 2-(aminomethyl)biphenyls. Application to the total synthesis of nobilone

Beilstein Journal of Organic Chemistry
Ilya A. P. Jourjine, Lukas Zeisel, Jürgen Krauß, Franz Bracher   +3 more
doaj   +1 more source

Recent Progress in the Total Synthesis and Biosynthesis of Arborisidine. [PDF]

Chirality
Dong S, Shi K, Guo J, Li L.
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Total Synthesis of Scandine. [PDF]

JACS Au
Kitamura T, Morita K, Umekubo N, Yokoshima S.   +3 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source