Results 231 to 240 of about 14,944,148 (406)

Total Synthesis of Annotinolide B via Sequential Quinoline Dearomatization. [PDF]

J Am Chem Soc
Duvvuru B, Smith MW.
europepmc   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Total Synthesis of Kavaratamides A-C and Unnatural Analogs. [PDF]

ACS Omega
Berida TI, Lindsley CW.
europepmc   +1 more source

Total Synthesis of Mandelalide A and Synthesis of (–)‐Zampanolide Analogs for Structure‐Activity Relationship Studies

, 2016
Tobias Michael Brà ⁄ tsch
openalex   +2 more sources

Total Synthesis of (+)-Pleuromutilin.

Journal of the American Chemical Society, 2018
Elliot P. Farney, Sean S Feng, Felix Schäfers, S. Reisman   +3 more
semanticscholar   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Collective Total Synthesis of a Unique Class of Liverworts-Derived Cembrane Diterpenoids. [PDF]

Angew Chem Int Ed Engl
Hermann A, Fürstner A.
europepmc   +1 more source

Development of a Triethylborane-Mediated Giese Cyclization/Aldol Reaction Cascade for the Total Synthesis of Ganoapplanin [PDF]

Nicolas Müller, Ondřej Kováč, Thomas Magauer, Daniel Atzl, Thomas Magauer   +4 more
openalex   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Correction: Synthesis of highly substituted fluorenones via metal-free TBHP-promoted oxidative cyclization of 2-(aminomethyl)biphenyls. Application to the total synthesis of nobilone

Beilstein Journal of Organic Chemistry
Ilya A. P. Jourjine, Lukas Zeisel, Jürgen Krauß, Franz Bracher   +3 more
doaj   +1 more source