Results 131 to 140 of about 7,929 (288)

The Intellectual and Totalitarianism

open access: yes, 2016
This flyer presents an event featuring speakers Monika Zgustova, Alejandro Rios, Martin Palous, and Marian Demos, on the subject of Intellectual and Totalitarianism .
Cuban Research Institute, Florida International University
core  

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Hannah Arendt and the political : the contemporary challenges posed by sovereignty, nationalism and imperialism

open access: yes, 2015
This thesis seeks to show how the reassessment of Arendt’s thought for contemporary international political theory must be grounded in her first major published work, The Origins of Totalitarianism, and, more specifically, in the concept of the political
Nicholas, Donna
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Global and National Totalitarianism from a Literary Perspective

open access: yes, 2020
Totalitarianism is a mass political phenomenon of the 20th century, which occurred in several states. According to the theory of totalitarianism, this is an era of mass terror, when full control over citizens is established by the state and there is no ...
Popiashvili, Nino
core  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Democracy, Mass Movement, Totalitarianism: Rethinking Hannah Arendt's Theory of Totalitarianism [PDF]

open access: yes
本稿は、ハンナ・アーレントの政治理論における全体主義とデモクラシーとの関係を再考し、その現代的意義を示すものである。そのため本稿では第一に『全体主義の起原』(1951)における「大衆運動」の記述を検証し、「大衆」と全体主義テロルとの関係は単純な加担や同調として描かれていないことを確認する。その際これまで看過されてきた陰謀論や秘密結社に関する記述に注目することで、アーレントの問題提起を再構成する。第二に、アーレントの全体主義論をカール・J・フリードリヒの議論と比較し、両者の共通点と相違点を明らかにする ...
石田,雅樹
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

Hans Magnus Enzensberger und deutsche Philosophie

open access: yesBrünner Beiträge zur Germanistik und Nordistik, 2016
First, this study deals with the problems that are connected with the reception of Enzensberger's works, second, it tries to put H. M. Enzensberger to the tradition of German postwar philosophy.
Aleš Urválek
doaj  

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