Results 141 to 150 of about 7,929 (288)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Legal features and legal culture under totalitarianism

open access: yes, 2015
The features of legal awareness and legal culture under totalitarianism. Substantiates the essential features of totalitarianism, which have a direct influence on the formation of legal awareness and legal culture of citizens.
Данильян, О.Г.
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Zeiten der Unsicherheiten. Demokratisierung und Nationalisierung in Ostmitteleuropa auf regionaler und lokaler Ebene (1918–1923)

open access: yesZeitschrift für Ostmitteleuropa-Forschung
Steffen Kailitz   +2 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Being political and the reconstruction of public discourse: Hannah Arendt on experience, history and the spectator

open access: yes, 2010
This study analyses a number of Hannah Arendt’s books and essays written over fourdecades and suggests that a common thread can be detected that links together thedifferent stages of her thought.
Leader, Jonathan W.
core  

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