Results 111 to 120 of about 58,366 (349)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

ORWELL A FOST MAI BINE CONECTAT LA POLITICA BRITANICĂ DECÂT CHURCHILL [PDF]

open access: yesRevista de Știinţe Politice şi Relaţii Internaţionale
There is a degree of congruence between Orwell and Churchill, a theme which forms the basis of Thomas Ricks’ book, Churchill and Orwell. In the 1930s, both Churchill and Orwell were outsiders, pursuing an agenda which failed to capture the public ...
Manolache, Viorella, Browne, Ian
doaj  

Banality of Evil and Instrumental Reason in Shirley Jackson’s “The Lottery”

open access: yesJournal of Literature and Humanities
This article offers a nuanced interpretation of Shirley Jackson’s short story “The Lottery” by engaging the theoretical frameworks of Hannah Arendt and Max Horkheimer.
Serhat Uyurkulak
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Îngropat în cer: Imre Kertész, Kadiș pentru copilul nenăscut [PDF]

open access: yesRevista de Istorie și Teorie Literară, 2016
2002 Nobel Literature Prize Winner, Imre Kertész, in his novel Kaddish for an Unborn Child, configures a path of Jewishness as “reconceptualization of the future” caused by the traumatic postHolocaust historical circumstances.
Cristina Deutsch
doaj  

Towards an Archaeology of the Contemporary Past [PDF]

open access: yes, 2002
Archaeology, defined as the study of material culture, extends from the first preserved human artefacts up to the present day, and in recent years the ‘Archaeology of the Present’ has become a particular focus of research.
Buchli, V
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

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