Results 111 to 120 of about 11,544 (277)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
ORWELL A FOST MAI BINE CONECTAT LA POLITICA BRITANICĂ DECÂT CHURCHILL [PDF]
Revista de Știinţe Politice şi Relaţii InternaţionaleThere is a degree of congruence between Orwell and Churchill, a theme which forms the basis of Thomas Ricks’ book, Churchill and Orwell. In the 1930s, both Churchill and Orwell were outsiders, pursuing an agenda which failed to capture the public ...
Manolache, Viorella, Browne, Ian
doaj
Democracy, epistemic agency, and AI: political epistemology in times of artificial intelligence. [PDF]
AI Ethics, 2022 Coeckelbergh M.
europepmc +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Totalitarianism in Hannah Arendt's political philosophy
, 2018 İki dünya savaşına da tanıklık etmiş olan Arendt, totalitarizmin kökenine inmeye çalışmış ve onun antisemitizm ve emperyalizm gibi iki unsurdan kaynaklandığını ileri sürmüştür.
Dalkıran, Döndü
core
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Bajo Palabra, 2017 Este artículo investiga, especialmente en los materiales inéditos del archivo de Gaos, la noción de totalitarismo como diagnóstico de su época. Gaos considera que a la modernización como proceso de laicización, tecnificación y degradación del sujeto y ...
Sergio Sevilla Segura
doaj
The last flight of F/O Tadeusz Stabrowski. Identification of the polish pilot. [PDF]
Front Genet, 2023 Lisman D +10 more
europepmc +1 more source