Results 121 to 130 of about 730,259 (221)

Sight-threatening optic neuropathy is associated with paranasal lymphoma

, 2010
Takahiko Hayashi1, Ken Watanabe2, Yukio Tsuura3, Gengo Tsuji4, Shingo Koyama4, Jun Yoshigi4, Naoko Hirata1, Shin Yamane1, Yasuhito Iizima5, Shigeo Toyota6, Satoshi Takeuchi11Department of Ophthalmology, Yokosuka Kyosai Hospital, Japan; 2Department of ...
Yukio Tsuura, Takahiko Hayashi, Ken Watanabe, et al   +3 more
core  

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Methanol Induced Optic Neuropathy: An Unusual Case With the Absence of Classic Symptoms

Clinical Case Reports
Methanol toxicity is an emergency that doctors come across all around the globe, requiring immediate treatment or it can cause life‐threatening conditions affecting the central nervous system, causing toxic optic neuropathy and metabolic acidosis.
Humza Tariq, Ali Gohar, Muhammad Husnain Ahmad, Muhammad Huzaifa Ameer, Masab Ali, Asad Ullah Ansari, Rehan Naseer Ahmad   +6 more
doaj   +1 more source

Ethambutol Toxic Optic Neuropathy in a Single Clinical Practice

, 2005
To present a case series of ethambutol toxic optic neuropathy (ETON) and to compare these with data from cases reported in ...
Ronel N. Santos; Aileen Antonio-Santos; Eric R. Eggenberger
core  

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Immune checkpoint inhibitor‐induced arrhythmias: Mechanistic insights from clinical and preclinical studies

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy, but their efficacy continues to be limited by immune‐related adverse events. Among these, ICI‐induced cardiac arrhythmias are increasingly recognised as a major adverse reaction, encompassing a broad spectrum of clinical phenotypes, including conduction blocks, atrial fibrillation and
Anand R. Ramalingam, Zoltán Márton Köhler, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

Clinical profile and visual outcomes in ethambutol-induced toxic optic neuropathy

Indian Journal of Ophthalmology
Purpose: To characterize the severity of vision loss, dose-related adverse effects, and visual outcomes in ethambutol-induced toxic optic neuropathy (ETON) patients.
Jenil Sheth, Virender Sachdeva, Ashima Goyal, Aditi Parikh, Rohan Nalawade, Hardik Nanavati, Ramesh Kekunnaya   +6 more
doaj   +1 more source

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

Tonic Water Toxic Optic Neuropathy Causing Vision Loss and Deafness

, 2020
We describe a case of likely toxic bilateral optic neuropathy and deafness in a 40-year-old man from quinine toxicity from heavy ingestion of tonic water, substantial alcohol use and heavy ...
Deborah C. Parish; Benson Chen; Nancy Newman; Valerie Biousse
core  

Identification of Copy Number Variants as a Suspected Cause of Cerebral Small Vessel Disease

Clinical Genetics, EarlyView.
Whole‐exome sequencing of 111 patients with suspected familial cerebral small vessel disease (CSVD) identified novel copy number variants in four patients across NOTCH3, LMNB1, and COL4A2, using bioinformatic and molecular techniques. These validated CNVs suggest structural variation is an underrecognized potential causal contributor to monogenic CSVD ...
Solomon K. Guyler, Neven Maksemous, Rodney A. Lea, Robert A. Smith, Heidi G. Sutherland, Lyn R. Griffiths   +5 more
wiley   +1 more source