Results 261 to 270 of about 35,227 (304)

Ecology of Toxic Shock Syndrome: Amplification of Toxic Shock Syndrome Toxin 1 by Materials of Medical Interest

Clinical Infectious Diseases, 1989
Historically, the literature suggests that staphylococcal exoproteins, including enterotoxins, are stimulated by various physicochemical ecologic factors, many of which have been shown to stimulate production of toxic shock syndrome toxin 1 (TSST-1).
P M, Tierno, B A, Hanna
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Toxic Shock Syndrome Toxin-1 Accelerated Collagen-induced Arthritis in Mice

Journal of Autoimmunity, 2001
The aim of this study was to explore the roles of toxic shock syndrome toxin-1 (TSST-1) in collagen-induced arthritis (CIA). DBA/1 mice were immunized with type II collagen (CII) and treated with TSST-1. Intraperitoneal and intravenous injections of TSST-1 aggravated CIA, enhancing its incidence and severity.
Y, Kageyama, Y, Koide, T, Nagata, M, Uchijima, A, Yoshida, T, Arai, T, Miura, C, Miyamoto, A, Nagano   +8 more
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Effect of toxic shock syndrome toxin-1 on human hemostatic parameters

Thrombosis Research, 1989
The effect of toxic-shock-syndrome-toxin-1 (TSST-1) on coagulation and platelet aggregation was studied in blood samples from human healthy volunteers. TSST-1 at 5 micrograms/ml does not modify the extrinsic or intrinsic coagulation pathways. However, thrombin clotting time (TCT) was significantly increased in the presence of TSST-1.
R, Gareau, J, Gruda, V V, Micusan
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Distribution and Expression of Toxic Shock Syndrome Toxin 1 Gene Among Staphylococcus aureus Isolates of Toxic Shock Syndrome and Non-Toxic Shock Syndrome Origin

Clinical Infectious Diseases, 1989
Toxic shock syndrome toxin 1 (TSST-1), plays a significant role in the pathogenesis of TSS. TSST-1 production is subject to physiologic and environmental constraints. Thus, DNA probes that detect the chromosomal gene encoding the toxin are of value diagnostically, epidemiologically, and for studies of gene expression.
P F, Bonventre, L, Weckbach, G, Harth, C, Haidaris   +3 more
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Toxicity of Staphylococcal Toxic Shock Syndrome Toxin 1 for Germ-Free and Conventional Piglets

Clinical Infectious Diseases, 1989
The susceptibilities of conventional and germ-free miniature pigs to staphylococcal toxic shock syndrome toxin 1 (TSST-1) were studied and compared. TSST-1 at doses of 100 micrograms/kg evoked reactions similar to those observed in rabbits, i.e., hyperthermia, diarrhea, apathy, conjunctival hyperemia, and various changes indicating toxic damage of ...
M, Bulanda, M, Zaleska, L, Mandel, M, Talafantova, J, Travnicek, G, Kunstmann, G, Mauff, G, Pulverer, P B, Heczko   +8 more
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Toxic Shock Syndrome Toxin 1 Contributes to the Arthritogenicity of Staphylococcus aureus

Journal of Infectious Diseases, 1994
Although enterotoxins have been implicated in disease states such as food poisoning and toxic shock syndrome, their role in infectious arthritis is not known. To study the arthritogenic properties of toxic shock syndrome toxin 1 (TSST-1), two pairs of S.
A, Abdelnour, T, Bremell, A, Tarkowski
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Toxic shock syndrome Staphylococcus aureus: effect of tampons on toxic shock syndrome toxin 1 production.

Obstetrics and gynecology, 1984
Tampons were tested for effect on growth and production of toxic shock syndrome toxin 1 by Staphylococcus aureus. Under good growth conditions, regular absorbency tampons had little effect on bacterial growth and inhibited toxin production two- to fourfold.
P M, Schlievert, D A, Blomster, J A, Kelly   +2 more
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Separation of Function Between the Domains of Toxic Shock Syndrome Toxin-1

The Journal of Immunology, 1998
Abstract Toxic shock syndrome toxin-1 (TSST1) is a superantigenic exotoxin produced by certain strains of Staphylococcus aureus. Structurally, TSST1 is composed of two domains: residues determined by crystallography to directly interact with MHC II molecules reside within the N-terminal domain, while TSST1 residues critical for ...
J L, Wahlsten, S, Ramakrishnan
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The role of toxic shock syndrome toxin-1 in the pathogenesis of toxic shock syndrome

1986
Toxic shock syndrome toxin-1 (TSST-1), an exoprotein produced by some strains of Staphylococcus aureus, is implicated in the pathogenesis of menstrual TSS. However, its role in nonmenstrual TSS is less certain. In order to study the pathogenetic role of TSST-1 in TSS, three approaches were taken: a) to develop an ELISA for detection of TSST-1 in ...
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Toxic Shock Syndrome Toxin 1 Is Encoded by a Variable Genetic Element

Clinical Infectious Diseases, 1989
The primary cause of toxic shock syndrome is toxic shock syndrome toxin 1 (TSST-1), a 22,049-dalton exotoxin. Approximately 20% of Staphylococcus aureus isolates produce TSST-1; the production of this toxin is therefore a variable genetic trait. The TSST-1 gene and its flanking sequences are found on a genetic element that is present in TSST-1-positive
B N, Kreiswirth, S J, Projan, P M, Schlievert, R P, Novick   +3 more
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