Results 41 to 50 of about 2,950,586 (348)

Flurochloridone induces responses of free radical reactions and energy metabolism disorders to BRL-3A cell

Ecotoxicology and Environmental Safety, 2022
Flurochloridone (FLC), a wildly used herbicide, could induce hepatotoxicity after long-term exposure to male rat, in addition to its reactive oxygen species (ROS)-dependent reproductive toxicity.
Liming Xue, Jiale Xu, Chao Feng, Zhijun Zhou, Yu’e Jin, Dasheng Lu, Guoquan Wang   +6 more
doaj   +1 more source

Toxicity of Microplastics and Nanoplastics in Mammalian Systems

International Journal of Environmental Research and Public Health, 2020
Fragmented or otherwise miniaturized plastic materials in the form of micro- or nanoplastics have been of nagging environmental concern. Perturbation of organismal physiology and behavior by micro- and nanoplastics have been widely documented for marine ...
C. Yong, S. Valiyaveettil, B. Tang
semanticscholar   +1 more source

A Quality Improvement Initiative to Standardize Pneumocystis jirovecii Pneumonia Prophylaxis in Pediatric Patients With Solid Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric patients with extracranial solid tumors (ST) receiving chemotherapy are at an increased risk for Pneumocystis jirovecii pneumonia (PJP). However, evidence guiding prophylaxis practices in this population is limited. A PJP‐related fatality at our institution highlighted inconsistent prescribing approaches and concerns about
Kriti Kumar, Denise M. Connolly, Ellen Kellington, Elyse Zelunka, Karla Kerrigan, Furqan Shaikh, Paul C. Nathan, Meredith S. Irwin, Sarah Cohen‐Gogo   +8 more
wiley   +1 more source

Pazopanib Combined With Vincristine and Irinotecan in Relapsed Wilms Tumor: Encouraging Outcomes in a Heavily Pretreated Pediatric Cohort

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While Wilms tumor (WT) typically has a favorable prognosis, relapsed cases—especially those with high‐risk histology—remain therapeutically challenging after intensive frontline therapy. The combination of vincristine and irinotecan has demonstrated activity in pediatric solid tumors, and pazopanib, a multi‐targeted tyrosine kinase ...
Maria Debora De Pasquale, Alessandro Crocoli, Giuseppe Maria Milano, Pierluigi Di Paolo, Francesca Diomedi Camassei, Ida Russo, Annalisa Serra   +6 more
wiley   +1 more source

Incidence and Outcome of Infants With Cancer in Canada: A Report From Cancer in Young People in Canada Database

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Infants with cancer are rare and face unique challenges. Our study aims to describe the incidence of infantile cancers in Canada and to compare treatment‐related mortality (TRM) and their outcomes with those of older children. Methods We conducted a retrospective cohort study using the Cancer in Young People in Canada database ...
Samuel Sassine, Hallie Coltin, Maria Kondyli, Monia Marzouki, Nicolas Prud'homme, Nida Usmani, Sylvia Cheng, Lesleigh Abbott, Tony Truong, Sapna Oberoi, Ketan Kulkarni, Josée Brossard, Lynette Bowes, Paul Gibson, Donna L. Johnston, Sarah McKillop, Roona Sinha, Lillian Sung, Catherine Vezina, Laura Wheaton, Alexandra P. Zorzi, Marie‐Claude Pelland‐Marcotte, Thai Hoa Tran   +22 more
wiley   +1 more source

Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group

Journal of Immunotherapy for Cancer, 2017
Cancer immunotherapy has transformed the treatment of cancer. However, increasing use of immune-based therapies, including the widely used class of agents known as immune checkpoint inhibitors, has exposed a discrete group of immune-related adverse ...
I. Puzanov, A. Diab, K. Abdallah, C. Bingham, C. Brogdon, R. Dadu, L. Hamad, S. Kim, M. Lacouture, N. LeBoeuf, D. Lenihan, C. Onofrei, V. Shannon, R. Sharma, A. Silk, D. Skondra, M. Suarez‐Almazor, Y. Wang, K. Wiley, H. Kaufman, M. Ernstoff, Jeff Deborah Stephanie Joan Janie Daniel David Ion Rena Anderson Arrindell Andrews Ballesteros Boyer Chen , J. Anderson, Deborah Arrindell, S. Andrews, J. Ballesteros, J. Boyer, Daniel S Chen, David Chonzi, I. Cotarla, R. Cunha, M. Davies, M. Dawson, A. Dicker, L. Eifler, Andrew D. Ferguson, C. Ferlini, S. Frankel, W. Go, Celestine G. Gochett, J. Goldberg, P. Goncalves, T. Goswami, Nancy C. Gregory, J. Gulley, V. Hayreh, Nicole Helie, William C. Holmes, J. hsu, R. Ibrahim, C. Larocca, K. Lehman, S. Ley-Acosta, O. Lambotte, J. Luke, J. Mcclure, Elisabete Michelon, Mary C. Nakamura, K. Patel, B. Piperdi, Z. Rasheed, D. Reshef, J. Riemer, C. Robert, M. Sarkeshik, Ann Saylors, J. Schreiber, K. Shafer-Weaver, W. Sharfman, E. Sharon, R. Sherry, C. Simonson, C. Thomas, John A Thompson, E. Trehu, D. Tresnan, M. Turner, Darshan Wariabharaj, I. Waxman, L. Wood, Lin Zhang, P. Zheng   +81 more
semanticscholar   +1 more source

Preoperative Cytopenia in Patients Affected by High‐Risk Neuroblastoma: Just a Matter of Platelets?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims In patients affected by high‐risk neuroblastoma (HR‐NB), complete macroscopic resection (CMR) is associated with better outcomes. These patients are often cytopenic due to intensive induction regimens. The aim of the present study is to assess the impact of preoperative cytopenia on surgical outcome in patients with HR‐NB ...
Giorgio Persano, Valerio Voglino, Federico Beati, Cristina Martucci, Chiara Grimaldi, Francesca Del Bufalo, Annalisa Serra, Francesco Fabozzi, Carmen Malaspina, Pier Luigi Di Paolo, Gian Luigi Natali, Simone Reali, Maria Antonietta De Ioris, Alessandro Crocoli   +13 more
wiley   +1 more source

Too toxic

Nursing Critical Care, 2007
Firm up on the facts and considerations associated with acetaminophen toxicity.
Scott, Saccomano, Deborah A, Deluca
openaire   +4 more sources

Relation of Adverse Childhood Experiences to Clinical and Patient‐Reported Outcomes for Adults With Sickle Cell Disease: A Registry Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Adverse childhood experiences (ACEs) are stressful or traumatic events prior to age 18 that are known to have a lasting impact on individuals’ health and well‐being. There is a gap in understanding the relationship between ACEs and Other Life Stressors and health status for adults with sickle cell disease (SCD).
Marsha Treadwell, Jessica Liang, Liliana Preiss, Angela Rivers, Jane S. Hankins, Allison King, Justin Williams, Michael B. Potter, Danielle Hessler   +8 more
wiley   +1 more source

What to Do When Medical Evidence Can Only Be Generated Through Routine Data: An Example From Pediatric Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Children undergoing allogeneic stem cell transplantation often receive off‐label rituximab treatment for Epstein–Barr virus reactivation, using adult dosing without pediatric evidence. This project aims to develop a clinical decision support tool (CDSS) that provides evidence‐based dosing scenarios by analyzing real‐world patient data.
Birgit Burkhardt, Antje Walz, Dietrich Knoerzer   +2 more
wiley   +1 more source