Results 81 to 90 of about 15,678,062 (402)

Disrupt toxicity testing [PDF]

Toxicology Research and Application, 2017
Dimensions of time that are relevant to molecular mechanisms are not incorporated into conventional toxicity testing methodologies. Historically, this was due to technological limitations. These limitations no longer exist. Application of real-time imaging and chemical sensor technologies presents an opportunity to overcome the challenges that have ...
Janis E Hulla, A Wallace Hayes
openaire   +1 more source

Targeting hypoxia-inducible factor-1α (HIF-1α) in combination with antiangiogenic therapy: a phase I trial of bortezomib plus bevacizumab. [PDF]

, 2014
PurposeWe hypothesized that bortezomib, an agent that suppresses HIF-1α transcriptional activity, when combined with bevacizumab, would obviate the HIF-1α resistance pathway.
Amin, Hesham M, Angelo, Laura S, Falchook, Gerald S, Hess, Kenneth, Hong, David, Howard, Adrienne N, Huang, Mei, Jackson, Edward F, Janku, Filip, Kurzrock, Razelle, Lawhorn, Kristie N, Naing, Aung, Ng, Chaan S, Parkhurst, Kristin L, Tannir, Nizar M, Vishwamitra, Deeksha, Wheler, Jennifer J   +16 more
core   +2 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Safety Assessment of a New Strain of Lactobacillus pentosus (IBRC=11143) as a Candidate Probiotic

Pharmaceutical and Biomedical Research, 2020
Background: It is believed that the consumption of an adequate amount of live lactic acid bacteria (as probiotic) may improve the health of the host. Many strains of lactic acid bacteria are generally considered to be safe.
Saba Bahrehvar, Shiva Khezri , Vahid Nejati, Amir Abbas Barzegari   +3 more
doaj  

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Experimental evaluation of acute toxicity heterometalic new compounds – tartratogermanat cooper and zinc

Zaporožskij Medicinskij Žurnal, 2017
One of the possible ways of creating new drugs is aiming synthesis of compounds previously envisaged activity. Perspective in this area is to obtain complexes based on metal ions and ligands.
G. P. Paniotova, P. B. Antonenko, V. V. Godovan, I. I. Seifullina, O. A. Chebanenko, K. H. Lobashova   +5 more
doaj   +1 more source

Toxicity of three comercial tannins to the nuisance invasive species Limnoperna fortunei (Dunker, 1857): implications for control [PDF]

, 2011
Adding biocides to water is one strategy to control macrofouling organisms. A natural biocide that helps to prevent/control macrofouling of Limnoperna fortunei (Dunker, 1857) on human installations is one way to minimize environmental impacts of ...
Bulus Rossini, Gustavo Daniel, Darrigran, Gustavo Alberto, Pereyra, Patricio Javier   +2 more
core  

SchussenAktivplus: reduction of micropollutants and of potentially pathogenic bacteria for further water quality improvement of the river Schussen, a tributary of Lake Constance, Germany [PDF]

, 2013
The project focuses on the efficiency of combined technologies to reduce the release of micropollutants and bacteria into surface waters via sewage treatment plants of different size and via stormwater overflow basins of different types. As a model river
Amler, Klaus, Blaha, Ludek, Gallert, Claudia, Giebner, Sabrina, Güde, Hans, Henneberg, Anja, Hess, Stefanie, Hetzenauer, Harald, Jedele, Klaus, Jung, Ralph-Michael, Kneipp, Sven, Krais, Stefanie, Kuch, Bertram, Köhler, Heinz-R., Lange, Claudia, Löffler, Herbert, Maier, Diana, Metzger, Jörg, Müller, Michael, Oehlmann, Jörg, Osterauer, Raphaela, Peschke, Katharina, Raizner, Jürgen, Rault, Magali, Rey, Peter, Richter, Doreen, Sacher, Frank, Scheurer, Marco, Schneider-Rapp, Jutta, Seifan, Merav, Spieth, Markus, Triebskorn, Rita, Vogel, Hans-Joachim, Weyhmüller, Michael, Winter, Josef, Wurm, Karl   +35 more
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Insecticide Effects on Normal Development and Hatch of Embryos of \u3ci\u3eParatanytarsus Parthenogeneticus\u3c/i\u3e (Diptera: Chironomidae) [PDF]

, 2017
Simple, low cost methods are needed to determine the effect of pesticides on non-target aquatic organisms. In this report, embryos of Paratanytarsus parthenogenetic us were exposed from deposition to hatch to five pesticides.
Anderson, Richard L, Shubat, Pam
core   +2 more sources