Results 31 to 40 of about 18,256 (198)
Dried blood spots in toxicology : from the cradle to the grave? [PDF]
, 2012 About a century after its first described application by Ivar Bang, the potential of sampling via dried blood spots (DBS) as an alternative for classical venous blood sampling is increasingly recognized.
De Kesel, Pieter +3 more
core +1 more source
A theoretical framework for estimation of AUCs in complete and incomplete sampling designs. [PDF]
, 2009 Nonclinical in vivo animal studies have to be completed before starting clinical studies of the pharmacokinetic behavior of a drug in humans. The drug exposure in animal studies is often measured by the area under the concentration versus time curve (AUC)
Jaki, Thomas, Wolfsegger, Martin J.
core +1 more source
Toxicity Study of 28-Day Subcutaneous Injection of Arctigenin in Beagle Dogs
Frontiers in Pharmacology, 2019 Our previous studies have investigated the systematic pharmacokinetic characteristics, biological activities, and toxicity of arctigenin. In this research, the potential toxicities of arctigenin in beagle dogs were investigated via repeated 28-day ...
Jie Li +28 more
doaj +1 more source
The percutaneous absorption of soman in a damaged skin porcine model and the evaluation of WoundStat™ as a topical decontaminant [PDF]
, 2017 PURPOSE: The aim of this study was to evaluate a candidate haemostat (WoundStat™), down-selected from previous in vitro studies, for efficacy as a potential skin decontaminant against the chemical warfare agent pinacoyl methylfluorophosphonate (Soman, GD)
Chilcott, Robert P +6 more
core +2 more sources
Безопасность и риск фармакотерапии, 2023 It is strategically critical to secure pharmaceutical independence for Russia by developing the industry using the latest achievements in science and technology.
A. A. Spasov
doaj +1 more source
The impact of deoxynivalenol on pigeon health : occurrence in feed, toxicokinetics and interaction with salmonellosis [PDF]
, 2016 Seed-based pigeon diets could be expected to result in exposure of pigeons to mycotoxins such as deoxynivalenol (DON). Ingestion of low to moderate contamination levels of DON may impair intestinal health, immune function and/or pathogen fitness ...
Antonissen, Gunther +11 more
core +4 more sources
EFSA Journal, 2011 The European Food Safety Authority (EFSA) was asked to evaluate a new study provided by industry that reports on the bioavailability of aluminium from several aluminium compounds in the rat.
European Food Safety Authority
doaj +1 more source
Frontiers in Toxicology, 2023 This case study aims to describe the dilemma faced when exposing rats to very high concentrations of fine, pulverulent materials for acute inhalation studies and to address the regulatory question of whether the effects seen here are relevant to humans ...
Heidi Stratmann +3 more
doaj +1 more source
Permitted daily exposure for diisopropyl ether as a residual solvent in pharmaceuticals [PDF]
, 2018 Solvents can be used in the manufacture of medicinal products provided their residual levels in the final product comply with the acceptable limits based on safety data.
Evandri, Maria Grazia, Romanelli, Luca
core +1 more source
Uptake, Elimination and Metabolism of Brominated Dibenzofurans in Mice
ToxicsPolybrominated dibenzofurans (PBDFs) are major brominated dioxins in the environment, but information on their bioaccumulation potential and toxicokinetics is limited.
Nguyen Minh Tue +6 more
doaj +1 more source