Results 41 to 50 of about 18,256 (198)

Applications of population approaches in toxicology [PDF]

open access: yes, 2000
International audienceMany experimental or observational studies in toxicology are best analysed in a population framework. Recent examples include investigations of the extent and origin of intra-individual variability in toxicity studies, incorporation
Bois, Frédéric Y.
core   +5 more sources

Benzene, toluene, ethylbenzene, and xylene: Current analytical techniques and approaches for biological monitoring

open access: yesReviews in Analytical Chemistry, 2020
Benzene, toluene, ethylbenzene, and xylene (BTEX) are a group of volatile organic compounds that human exposure to them may result in the development of some diseases, including cancer. Biological monitoring plays an important role in exposure assessment
Soleimani Esmaeel
doaj   +1 more source

Calcination Improves the In Vivo Efficacy of a Montmorillonite Clay to Bind Aflatoxin G1 in Broiler Chickens: A Toxicokinetic Approach

open access: yesToxins, 2020
The goal of this study was to investigate the toxicokinetic characteristics of aflatoxin G1 (AFG1) in broiler chickens and the effect of calcination of a Tunisian montmorillonite clay on the in vivo absorption of AFG1.
Roua Rejeb   +7 more
doaj   +1 more source

EURL ECVAM strategy for achieving 3Rs impact in the assessment of toxicokinetics and systemic toxicity [PDF]

open access: yes, 2015
Information on human toxicokinetics plays an important role in the safety assessment of chemicals, even though there are few data requirements in the EU regulatory framework.
BESSEMS JOSEPH   +4 more
core   +1 more source

Establishment of an isotope dilution LC-MS/MS method revealing kinetics and distribution of co-occurring mycotoxins in rats [PDF]

open access: yes, 2012
An isotope dilution liquid chromatography-tandem mass spectrometry (LC-MS/MS) method with a fast sample preparation using homemade clean-up cartridges was developed for simultaneous determination of co-occurring mycotoxins exemplified with aflatoxin B1 ...
De Saeger, Sarah   +10 more
core   +1 more source

Study of the Safety and Toxicokinetic Parameters of the Drug Eladis® in Preclinical Trials with Repeated Administration

open access: yesАнтибиотики и Химиотерапия
Cough is one of the most common reasons for initial visits to healthcare providers, affecting 40–50% of patients with viral respiratory tract infections.
A. A. Matichin   +11 more
doaj   +1 more source

Toxicologie industrielle et vieillissement

open access: yesPerspectives Interdisciplinaires sur le Travail et la Santé, 2004
Several physiological and biochemical changes accompany aging and can affect the metabolism of chemicals and the body’s response. A literature review was carried out to identify these changes and their potential impact on the health of aging workers. The
Ginette Truchon   +2 more
doaj   +1 more source

Multimodal Cross‐Attentive Graph‐Based Framework for Predicting In Vivo Endocrine Disruptors

open access: yesAdvanced Science, EarlyView.
A multimodal cross‐attentive graph neural network integrates molecular graphs with androgen and estrogen adverse outcome pathway (AOP)–anchored in vitro assay signals to predict in vivo endocrine disruption. By fusing information on Tier‐1 AOP logits with chemical structures, the framework achieves high accuracy and provides assay‐traceable ...
Eder Soares de Almeida Santos   +6 more
wiley   +1 more source

Sex and Cross-Sex Testosterone Treatment Alters Gamma-Hydroxybutyrate Acid Toxicokinetics and Toxicodynamics in Rats

open access: yesPharmaceutics
Γ-hydroxybutyric acid (GHB) is widely abused due to its sedative/hypnotic and euphoric effects. In recent years, GHB use has witnessed a notable rise within the LGBTQ+ community.
Qing Zhang   +3 more
doaj   +1 more source

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