Results 131 to 140 of about 53,939 (264)

Animal models in molecular biology research: Challenges, ethical imperatives, and the path to human‐relevant translation

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract shows how molecular biology research has shifted from using traditional animal models toward using methods that are more relevant to humans. It points out the main problems, differences between species, difficulty in reproducing results, moral issues, and lack of infrastructure that make translational accuracy harder to achieve ...
Md. Shajid Hossain Rafi, Md. Taslim Sarker, Ferdous‐Ul‐Haque Joy, Shahriar Mohd Shams, Tahmina Foyez, Md. Abdul Mazid, Syed Masudur Rahman Dewan   +6 more
wiley   +1 more source

Toxicological Evaluation and Antimicrobial Activity of a Natural Thymol-Eucalyptol-Based Mixture. [PDF]

Toxics
Lira-Mejía B, Barrios-Arpi L, Villaorduña C, Ancajima T, Rodríguez JL, Romero A, Puicón V, Patiño H.   +7 more
europepmc   +1 more source

Cerebrospinal Fluid from Restless Legs Syndrome Patients Reduces Iron Uptake in Blood–Brain Barrier Endothelial Cells by Disrupting the Regulation of Transferrin Receptors

Annals of Neurology, EarlyView.
Model figure of BBBECs TfR1 regulation in control and RLS: Graphical representation of TfR1 regulation in ECs by IRPs and representing it can be dysregulated by miR‐124‐3p in ECs of RLS. FPN1, ferroportin; BBBEC, blood‐brain barrier endothelial cells; IRP, iron regulatory proytein1/2; TfR1, Transferrin receptor; IRE, Iron responsive elements; Tf ...
Kondaiah Palsa, Aurosman Pappus Sahu, David B. Rye, Lynn Marie Trotti, Irina A. Elcheva, Vladimir S. Spiegelman, James R. Connor   +6 more
wiley   +1 more source

Toxicological Evaluation of Vanillin Flavor in E-Liquid Aerosols on Endothelial Cell Function: Findings from the Replica Project. [PDF]

Cardiovasc Toxicol
Emma R, Sun A, Partsinevelos K, Rust S, Volarevic V, Lesmana R, Giordano A, Goenawan H, Barliana MI, Arsenijevic A, Kastratovic N, Markovic V, Spasic B, Distefano A, Orlando L, Carota G, Polosa R, Caruso M, Li Volti G.   +18 more
europepmc   +1 more source

Natural Aging of Biomaterials in Ambient and Physiological Environments

Advanced NanoBiomed Research, EarlyView.
Biomaterials used in biomedical applications can change their physical properties over time, even under ambient and physiological conditions. This review highlights key studies on the natural aging of materials ranging from soft hydrogels to metals and ceramics, emphasizing how time‐dependent changes influence function and performance.
Shuyu Zhang, Anne E. Staples
wiley   +1 more source

Nanodiamonds as Bioactive Platforms to Modulate Microbial, Mammalian, and Vertebrate Systems

Advanced NanoBiomed Research, EarlyView.
Nanodiamonds (NDs) are biocompatible and antibacterial nanomaterials that support mammalian cell growth while inhibiting bacterial pathogens. NDs showed strong antibacterial activity, with Escherichia coli being more sensitive than Staphylococcus aureus. At 10 mg/mL, both bacteria exhibited ~8% viability.
Aaqil Rifai, Ayushi Priyam, Ahmed Rashed, Gebreselassie Addisu Tilaye, Kamal Poudel, Aaron G. Schultz, Richard J. Williams   +6 more
wiley   +1 more source

Toxicological Evaluation of Ionic Liquids: QSAR Approach for Acetylcholinesterase Enzyme Inhibition. [PDF]

Chem Res Toxicol
Ebrahimpoor Gorji A, Uusi-Kyyny P, Alopaeus V.   +2 more
europepmc   +1 more source

Phytochemical Profiling and Toxicological Evaluation of <i>Atraphaxis virgata</i> and <i>Atraphaxis pyrifolia</i> Extracts Using GC-MS and LC-MS. [PDF]

Molecules
Dauletova MD, Umbetova AK, Kabdraisova AZ, S Iminova R, Burasheva GS, Litvinenko YA, Yelibayeva NS, Kurbatova NV, Korul'kin DY, Ibragimova NA, Bugubaeva GO, Zhumabayev MR.   +11 more
europepmc   +1 more source

Preclinical Pharmacological and Toxicological Evaluation of SB5794, a Novel Aryl Hydrocarbon Receptor Modulator on the Kynurenine-AhR Axis. [PDF]

Biomol Ther (Seoul)
Cha D, Choi SJ, Park H, Lee DY, Joo MS, Lee W, Park J, Lee E, Kim H.   +8 more
europepmc   +1 more source

Toxicological evaluation of aqueous leaf extract of Terminalia catappa linn (combretaceae) in pregnant rats. [PDF]

Pan Afr Med J, 2023
Abdullahi M, Magaji SY, Ibrahim ZG, Yunusa S, John A, Muhammad I, Muhammad YA, Malami S, Chedi BZ.   +8 more
europepmc   +1 more source