Results 1 to 10 of about 102,247,329 (239)

Potency Testing of Venoms and Antivenoms in Embryonated Eggs: An Ethical Alternative to Animal Testing

Toxins, 2021
Venoms are complex mixtures of biologically active molecules that impact multiple physiological systems. Manufacture of antivenoms (AVs) therefore requires potency testing using in vivo models to ensure AV efficacy. As part of ongoing research to replace
Erin E. Verity, Kathy Stewart, Kirsten Vandenberg, Chi Ong, Steven Rockman   +4 more
doaj   +3 more sources

Human IPSC 3D brain model as a tool to study chemical-induced dopaminergic neuronal toxicity

Neurobiology of Disease, 2022
Oxidative stress is caused by an imbalance between the generation and detoxification of reactive oxygen and nitrogen species (ROS/RNS). This imbalance plays an important role in brain aging and age-related neurodegenerative diseases.
David Pamies, Daphne Wiersma, Moriah E. Katt, Liang Zhao, Johannes Burtscher, Georgina Harris, Lena Smirnova, Peter C. Searson, Thomas Hartung, Helena T. Hogberg   +9 more
doaj   +1 more source

Airborne toxicological assessment: The potential of lung-on-a-chip as an alternative to animal testing

Materials Today Advances, 2022
Recent studies have shown that there exists a direct relationship between environmental pollutants (PM2.5, smog), the respiratory system, and the morbidity and mortality of cardiovascular diseases.
K.-C. Lin, C.-Z. Yen, J.-W. Yang, J.H.Y. Chung, G.-Y. Chen   +4 more
doaj   +1 more source

Innovative Human Three-Dimensional Tissue-Engineered Models as an Alternative to Animal Testing

Bioengineering, 2020
Animal testing has long been used in science to study complex biological phenomena that cannot be investigated using two-dimensional cell cultures in plastic dishes.
Patrick Bédard, Sara Gauvin, Karel Ferland, Christophe Caneparo, Ève Pellerin, Stéphane Chabaud, Stéphane Bolduc   +6 more
doaj   +1 more source

Skin Sensitization Evaluation of Carbon-Based Graphene Nanoplatelets

Toxics, 2021
Graphene nanoplatelets (GNPs) are one of the major types of carbon based nanomaterials that have different industrial and biomedical applications. There is a risk of exposure to GNP material in individuals involved in their large-scale production and in ...
Sung-Hyun Kim, So-Hye Hong, Jin Hee Lee, Dong Han Lee, Kikyung Jung, Jun-Young Yang, Hyo-Sook Shin, JeongPyo Lee, Jayoung Jeong, Jae-Ho Oh   +9 more
doaj   +1 more source

Bioreactor analyses of tissue ingrowth, ongrowth and remodelling around implants: An alternative to live animal testing

Frontiers in Bioengineering and Biotechnology, 2023
Introduction: Preclinical assessment of bone remodelling onto, into or around novel implant technologies is underpinned by a large live animal testing burden. The aim of this study was to explore whether a lab-based bioreactor model could provide similar
Nupur Kohli, Konstantinos Theodoridis, Thomas A. G. Hall, Inigo Sanz-Pena, David C. A. Gaboriau, Richard J. van Arkel   +5 more
doaj   +1 more source

Evaluation of the Skin Sensitization Potential of Carbon Nanotubes Using Alternative In Vitro and In Vivo Assays

Toxics, 2020
Carbon nanotubes (CNTs) are one of the major types of nanomaterials that have various industrial and biomedical applications. However, there is a risk of accidental exposure to CNTs in individuals involved in their large-scale production and in ...
Sung-Hyun Kim, Dong Han Lee, Jin Hee Lee, Jun-Young Yang, Hyo-Sook Shin, JeongPyo Lee, Kikyung Jung, Jayoung Jeong, Jae-Ho Oh, Jong Kwon Lee   +9 more
doaj   +1 more source

A review on alternative methods to experimental animals in biological testing: Recent advancement and current strategies

Journal of Pharmacy and Bioallied Sciences, 2023
With an increase in the progression of research and development in the medical field, the experimental use of animals for the efficacy and safety testing of pharmaceuticals is on rise.
Asif Husain, Dhanalekshmi U Meenakshi, Aftab Ahmad, Neelima Shrivastava, Shah A Khan   +4 more
doaj   +1 more source

A first vascularized skin equivalent as an alternative to animal experimentation

ALTEX: Alternatives to Animal Experimentation, 2016
Tissue-engineered skin equivalents mimic key aspects of the human skin and can thus be employed as wound coverage for large skin defects or as in vitro test systems as an alternative to animal models.
Florian Groeber, Lisa Engelhardt, Julia Lange, Szymon Kurdyn, Freia F. Schmid, Christoph Rücker, Stephan Mielke, Heike Walles, Jan Hansmann   +8 more
doaj   +1 more source

Bottom-up physiologically-based biokinetic modelling as an alternative to animal testing

ALTEX: Alternatives to Animal Experimentation, 2019
There is a growing need to develop alternatives to animal testing to derive biokinetic data for evaluating both efficacy and safety of chemicals. One such alternative is bottom-up physiologically-based biokinetic (PBK) modeling, which requires only in ...
James C. Y. Chan, Shawn P. F. Tan, Zee Upton, Eric C. Y. Chan   +3 more
doaj   +1 more source