Results 1 to 10 of about 87,684,257 (245)
Potency Testing of Venoms and Antivenoms in Embryonated Eggs: An Ethical Alternative to Animal Testing [PDF]
Toxins, 2021 Venoms are complex mixtures of biologically active molecules that impact multiple physiological systems. Manufacture of antivenoms (AVs) therefore requires potency testing using in vivo models to ensure AV efficacy. As part of ongoing research to replace
Erin E. Verity +4 more
doaj +4 more sources
Innovative Human Three-Dimensional Tissue-Engineered Models as an Alternative to Animal Testing [PDF]
Bioengineering, 2020 Animal testing has long been used in science to study complex biological phenomena that cannot be investigated using two-dimensional cell cultures in plastic dishes.
Patrick Bédard +6 more
doaj +2 more sources
In ovo model with emu eggs as novel alternative to animal testing in preclinical imaging research [PDF]
EJNMMI ResearchBackground Large-size in ovo models are receiving increasing attention since they comply with the 3R requirements (Replacement, Reduction and Refinement) by limiting the number of fully developed laboratory animals.
Olga Perkas +7 more
doaj +2 more sources
Alternative Methods to Animal Testing for the Safety Evaluation of Cosmetic Ingredients: An Overview
Cosmetics, 2017 The safety of cosmetics sold in Europe is based on the safety evaluation of each individual ingredient conducted by those responsible for putting the product on the market.
Maria Pilar Vinardell +1 more
doaj +3 more sources
Human IPSC 3D brain model as a tool to study chemical-induced dopaminergic neuronal toxicity
Neurobiology of Disease, 2022 Oxidative stress is caused by an imbalance between the generation and detoxification of reactive oxygen and nitrogen species (ROS/RNS). This imbalance plays an important role in brain aging and age-related neurodegenerative diseases.
David Pamies +9 more
doaj +1 more source
Materials Today Advances, 2022 Recent studies have shown that there exists a direct relationship between environmental pollutants (PM2.5, smog), the respiratory system, and the morbidity and mortality of cardiovascular diseases.
K.-C. Lin +4 more
doaj +1 more source
Skin Sensitization Evaluation of Carbon-Based Graphene Nanoplatelets
Toxics, 2021 Graphene nanoplatelets (GNPs) are one of the major types of carbon based nanomaterials that have different industrial and biomedical applications. There is a risk of exposure to GNP material in individuals involved in their large-scale production and in ...
Sung-Hyun Kim +9 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2023 Introduction: Preclinical assessment of bone remodelling onto, into or around novel implant technologies is underpinned by a large live animal testing burden. The aim of this study was to explore whether a lab-based bioreactor model could provide similar
Nupur Kohli +5 more
doaj +1 more source
Toxics, 2020 Carbon nanotubes (CNTs) are one of the major types of nanomaterials that have various industrial and biomedical applications. However, there is a risk of accidental exposure to CNTs in individuals involved in their large-scale production and in ...
Sung-Hyun Kim +9 more
doaj +1 more source