Results 41 to 50 of about 102,247,329 (239)

Analysis of the proposed EU Regulation concerning biocide products and its opportunities for alternative approaches and a toxicology for the 21st century

ALTEX: Alternatives to Animal Experimentation, 2012
On June 12, 2009, the European Commission adopted a proposal for a Regulation concerning the placement on the market and use of biocidal products, which, when it enters into force on January 1, 2013, will repeal and replace Directive 98/8/EC.
Daniele Ferrario, Richard R. Rabbit
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

ZEBET's activities to promote alternative methods for the ID50 potency test in botulinum neurotoxin product testing

, 2010
Botulinum neurotoxin (BoNT) products are used for treatment of many medical disorders such as cervical dystonia or blepharospasm. Prior to release, every production lot of BoNT requires characterisation in a mouse LD50 potency test according to the ...
Liebsch,M., Luch,A., Grune,B., Adler,S.
core   +1 more source

Effects of different simplified milk recording methods on genetic evaluation with Test-Day animal model

Italian Journal of Animal Science, 2010
The aims of the present study were to compare estimated breeding values (EBV) for milk yield using different testing schemes with a test-day animal model and to evaluate the effect of different testing schemes on the ranking of top sheep.
D. Cacioppo, M. Tolone, V. Riggio, D.O. Maizon, B. Portolano   +4 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Combining the zebrafish embryo developmental toxicity assay (ZEDTA) with hemoglobin staining to accelerate the research of novel antimalarial drugs for pregnant women

International Journal for Parasitology: Drugs and Drug Resistance
Background: Malaria during pregnancy implies a high risk for the mother and the developing child. However, the therapeutic options for pregnant women have historically been very limited, especially during the first trimester of pregnancy due to potential
Lucia Borrallo-Lopez, Laura Guzman, Noelia G. Romero, Anna Sampietro, Ana Mallo-Abreu, Laia Guardia-Escote, Elisabet Teixidó, Burkhard Flick, Xavier Fernàndez-Busquets, Diego Muñoz-Torrero, Marta Barenys   +10 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Implementation, availability and regulatory status of an OECD accepted Reconstructed Human Epidermis model in Brazil

Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, 2018
Introduction: In 2014, Brazil has joined the growing list of countries to ban cosmetic products from being tested on animal models. The new legislation comes into force in 2019.
Rodrigo De Vecchi, Vanja Dakic, Guilherme Mattos, Anne-Sophie Rigaudeau, Veronica Oliveira, Cristina Garcia, Nathalie Alépée, José Cotovio, Charbel Bouez   +8 more
doaj   +7 more sources

Antibiotic-induced dysbiosis in the SCIME™ recapitulates microbial community diversity and metabolites modulation of in vivo disease

Frontiers in Microbiology
Establishing the contextIntestinal dysbiosis is a significant concern among dog owners, and the gut health of pets is an emerging research field. In this context, the Simulator of the Canine Intestinal Microbial Ecosystem (SCIME™) was recently developed ...
Elena Dalle Vedove, Alessia Benvenga, Gianluca Nicolai, Marcella Massimini, Maria Veronica Giordano, Francesco Di Pierro, Francesco Di Pierro, Benedetta Bachetti   +7 more
doaj   +1 more source

Adverse outcome pathways as a tool for the design of testing strategies to support the safety assessment of emerging advanced materials at the nanoscale

Particle and Fibre Toxicology, 2020
Toxicity testing and regulation of advanced materials at the nanoscale, i.e. nanosafety, is challenged by the growing number of nanomaterials and their property variants requiring assessment for potential human health impacts. The existing animal-reliant
Sabina Halappanavar, Sybille van den Brule, Penny Nymark, Laurent Gaté, Carole Seidel, Sarah Valentino, Vadim Zhernovkov, Pernille Høgh Danielsen, Andrea De Vizcaya, Henrik Wolff, Tobias Stöger, Andrey Boyadziev, Sarah Søs Poulsen, Jorid Birkelund Sørli, Ulla Vogel   +14 more
doaj   +1 more source