Results 41 to 50 of about 87,684,257 (245)
Frontiers in MicrobiologyEstablishing the contextIntestinal dysbiosis is a significant concern among dog owners, and the gut health of pets is an emerging research field. In this context, the Simulator of the Canine Intestinal Microbial Ecosystem (SCIME™) was recently developed ...
Elena Dalle Vedove +7 more
doaj +1 more source
Open source software toolchain for automated non‐targeted screening for toxins in alternative foods
MethodsX, 2021 Previous published methods for non-targeted screening of toxins in alternative foods such as leaf concentrate, agricultural residues or plastic fed to biological consortia are time consuming and expensive and thus present accessibility, as well as, time ...
S.W. Breuer +3 more
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
A human liver organoid platform for hepatotoxicity assessment: evaluation using reference compounds
Frontiers in ToxicologyBackgroundRecent advances in organoid technology have enabled the development of human-relevant models. However, their application in toxicity assessments remains limited.
Min Jeong Kim +9 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
, 2020 To date traditional toxicity testing has relied heavily on in-life animal studies that are expensive and restrictive with regards to very important ethical implications. In addition, these studies often yield data that are not relevant to human exposures
Kermanizadeh, A.
core +1 more source
, 2022 SIMPLE SUMMARY: The European Union (EU) has made commitments to review all established policies on farm animal welfare and by the end of 2023 propose new regulations that will improve farming conditions and phase out the use of cage-based systems. A case
Mariann Molnár, Molnár, Mariann
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Animal Rights Coalitions Coordinator\u27s Report \u2786 [PDF]
, 1987 New strategies fuel progress, promise even greater gains Milestones On a personal note Here\u27s what you can do to make a difference Promoting animal rights at the community level (Ann T.
Animal Rights Coalitions
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Frontiers in Toxicology, 2021 In 2012, the Council of Canadian Academies published the expert panel on integrated testing of pesticide’s report titled: Integrating emerging technologies into chemical safety assessment. This report was prepared for the Government of Canada in response
Yadvinder Bhuller +5 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source