Results 61 to 70 of about 102,247,329 (239)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

International cooperation for alternatives to animal testing

Folia Pharmacologica Japonica, 2011
動物実験代替法（以下，代替法と記す）の開発を促すために各国に設立された代替法バリデーションセンターの協調を図るため，2009年に日米欧カナダの参加で，代替試験法協力国際会議（ICATM: International Cooperation on Alternative Test Methods）の覚書が交わされ，代替法の開発に国際協調がより重要視されることになった．さらに，2011年には韓国の追加参入が決まり，新たな覚書が交わされた．このICATMの取り決めに準じた日本動物実験代替法評価センター（JaCVAM: Japanese Center for the Validation of Alternative Methods）の活動状況および今後の国際対応についてまとめた．本来なら ...
openaire   +3 more sources

Animal Testing in Infectiology /

, 2001
Animal testing has a long history, and the resulting knowledge has brought about a significant contribution to the improvement of health and welfare of mankind and animals. Federal regulations concerning the performance of animal testing have become more
Schmidt, A.
core  

Animal Welfare Ethics in Research and Testing: Implementation and its Barrier [PDF]

, 2020
Animals have an important role in research and testing to improve human and animal health. Animal usage must be balanced between science and ethical values of animal welfare.
Wahyuwardani, Sutiastuti, Noor, S M, Bakrie, B, S M Noor, Sutiastuti Wahyuwardani, B Bakrie   +5 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Safety testing of cell-based medicinal products: Opportunities for the monocyte activation test for pyrogens

ALTEX: Alternatives to Animal Experimentation, 2007
The European Partnership for Alternative Approaches to Animal Testing (EPAA) pointed out the need to involve authorities throughout the process of validation and legal acceptance of alternatives to animal experiments.
Thomas Montag, Ingo Spreitzer, Bettina Löschner, Uwe Unkelbach, Egbert Flory, Ralf Sanzenbacher, Michael Schwanig, Christian K. Schneider   +7 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Alternatives to animal testing: current status and future perspectives [PDF]

, 2011
On the occasion of the 20th anniversary of the Center for Alternative Methods to Animal Experiments (ZEBET), an international symposium was held at the German Federal Institute for Risk Assessment (BfR) in Berlin.
Butzke, D., Seiler, A., Ralph Pirow, Oelgeschläger, M., Riebeling, C., Sarah Adler, Adler, S., Manfred Liebsch, Michael Oelgeschläger, Liebsch, M., Andreas Luch, Grune, B., Andrea Seiler, Barbara Grune, Daniel Butzke, Christian Riebeling, Pirow, R., Luch, A.   +17 more
core   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Botulinum toxin testing on animals is still a Europe-wide issue

ALTEX: Alternatives to Animal Experimentation, 2019
There have been significant developments in the use of animals to test Botulinum toxin products in Europe in recent years. This paper summarises and discusses these from the perspective of the animal protection organisation.
Katy Taylor, Corina Gericke, Laura Rego Alvarez   +2 more
doaj   +1 more source