Results 71 to 80 of about 102,247,329 (239)
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
In ovo model with emu eggs as novel alternative to animal testing in preclinical imaging research
EJNMMI ResearchBackground Large-size in ovo models are receiving increasing attention since they comply with the 3R requirements (Replacement, Reduction and Refinement) by limiting the number of fully developed laboratory animals.
Olga Perkas +7 more
doaj +1 more source
LifeBackground: Animal studies remain fundamental to cardiovascular drug and device development, yet their ability to predict human responses is increasingly being questioned.
Rasit Dinc, Nurittin Ardic
doaj +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Application of omics to immunotoxicology : from mechanisms of action to alternative testing strategies [PDF]
, 2015 Currently, immunotoxicity testings are mainly based on animal models. However, animal testing has several drawbacks, including limited prediction towards human due to interspecies differences, time and money consuming nature, and the ethical concerns ...
Shao, J., J. Shao
core +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
, 2020 To date traditional toxicity testing has relied heavily on in-life animal studies that are expensive and restrictive with regards to very important ethical implications. In addition, these studies often yield data that are not relevant to human exposures
Kermanizadeh, A.
core +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Free the animals? Investigating attitudes toward animal testing in Britain and the United States
, 2008 In this study, 185 British and 143 American undergraduates completed a battery of tests that measured attitudes toward animal testing and various individual difference variables.
Christopher, Andrew N. +5 more
core +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source