Results 71 to 80 of about 87,684,257 (245)
, 2010 Botulinum neurotoxin (BoNT) products are used for treatment of many medical disorders such as cervical dystonia or blepharospasm. Prior to release, every production lot of BoNT requires characterisation in a mouse LD50 potency test according to ...
Liebsch,M., Luch,A., Grune,B., Adler,S.
core +1 more source
Microfluidics-based skin irritation test using in vitro 3D angiogenesis platform
APL Bioengineering, 2019 A global ban on animal experiments has been proposed. Hence, it is imperative to develop alternative models. Artificial skin models should reflect the responses of subcutaneous blood vessels and the immune system to elucidate disease and identify ...
Norhana Jusoh, Jihoon Ko, Noo Li Jeon
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
The european consensus platform for 3R alternatives to animal experimentation (ECOPA)
, 2018 International audienceThe ecopa is a non-profit organization which explores all possible means to improve the exchange of information in the area of alternative methods.
Bastos, L. +3 more
core +2 more sources
Regional issues on animal genetic resources: trends, policies and networking in Europe [PDF]
, 2010 European countries are individually and in collaboration carrying out active work on animal genetic resources (AnGR). The region has a very good starting point for work on AnGR: The breed concept was developed in Europe; current European mainstream ...
A. Mäki-Tanila +5 more
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Wellcome Open ResearchRegulating industrial chemicals in foodstuffs and consumer products is a major aspect of protecting populations against health risks. Non-animal testing methods are an essential part of the radical change to the framework for toxicity testing that is ...
Annamaria Carusi
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Systems biology in animal sciences [PDF]
, 2011 Systems biology is a rapidly expanding field of research and is applied in a number of biological disciplines. In animal sciences, omics approaches are increasingly used, yielding vast amounts of data, but systems biology approaches to extract ...
Pas, M.F.W., te +11 more
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