Results 81 to 90 of about 102,247,329 (239)
, 2016 This chapter explores the concepts, processes, tools and challenges relating to the validation of alternative methods for toxicity and safety testing. In general terms, validation is the process of assessing the appropriateness and usefulness of a tool ...
GRIESINGER Claudius +4 more
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EURL ECVAM Status Report on the Development, Validation and Regulatory Acceptance of Alternative Methods and Approaches (2016) [PDF]
, 2016 Replacement, Reduction and Refinement of animal testing is anchored in EU legislation. Alternative non-animal approaches facilitate a shift away from animal testing.
VIEGAS BARROSO Joao Filipe +30 more
core +1 more source
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
The 1, 2, 3 of laboratory animal experimentation
Revista Peruana de Medicina Experimental y Salud Pública, 2016 The slow scientific development in Latin America in recent decades has delayed the incorporation of laboratory animal experimentation; however, this situation has started to change.
Wilber Romero-Fernandez +7 more
doaj +1 more source
, 2023 This internet resource contains issues published throughout multiple years2023 Livestock Brand Renewal Window is Currently Open! -- New: Free Electronic CVI Available for Veterinarians -- Statewide FMD Exercise -- USDA Seeks Public Comment on Proposal to
Kansas Animal Health
core
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source
Animal testing and its alternatives – the most important omics is economics
ALTEX: Alternatives to Animal Experimentation, 2018 For a long time, the discussion about animal testing vs its alternatives centered on animal welfare. This was a static warfare, or at least a gridlock, where life scientists had to take a position and make their value choices and hardly anyone changed ...
Lucy Meigs +4 more
doaj +1 more source
, 2008 The development of the nervous system is a rather complex process known to be affected by different drugs and chemicals. Therefore, regulatory test guidelines have been adopted for the prediction and assessment of developmental neurotoxicity (U.S.EPA ...
Slawik,B. +6 more
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Journal of Animal Reproduction and BiotechnologyBackground: The small intestine plays a crucial role in animals in maintaining homeostasis as well as a series of physiological events such as nutrient uptake and immune function to improve productivity.
Bo Ram Lee +4 more
doaj +1 more source