Results 11 to 20 of about 87,684,257 (245)

STopTox: An In-Silico Alternative to Animal Testing for Acute Systemic and TOPical TOXicity [PDF]

, 2020
Since 2009, animal testing for cosmetic products has been prohibited in Europe, and in 2016, US EPA announced their intent to modernize the so-called "6-pack" of acute toxicity tests (acute oral toxicity, acute dermal toxicity, acute inhalation toxicity,
Joyce V. V. B., Borba, Alexander, Tropsha, Kirsten, Overdahl, Judy, Strickland, Steven, Hall, Erik, Overdahl, DAvid, Allen, Carolina, Andrade, Daniel, Korn, Vinicius, Alves, Arthur C., Silva, Eugene, Muratov, Rodolpho, Braga, Nicole, Kleinstreuer   +13 more
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A review on alternative methods to experimental animals in biological testing: Recent advancement and current strategies

Journal of Pharmacy and Bioallied Sciences, 2023
With an increase in the progression of research and development in the medical field, the experimental use of animals for the efficacy and safety testing of pharmaceuticals is on rise.
Asif Husain, Dhanalekshmi U Meenakshi, Aftab Ahmad, Neelima Shrivastava, Shah A Khan   +4 more
doaj   +1 more source

Cytotoxicity assay as potential alternative method to animal testing for batch release of Italian fish autogenous vaccines

Open Veterinary Journal, 2023
Background: Vaccination is widely used in fish aquaculture for three primary reasons: to prevent bacterial disease spreading, minimize antibiotic use and fight antibiotic resistance.
Antonella Di-Paolo, Lucia Anzalone, Martina Pellegrini, Giulio Sveri, Monica Cagiola   +4 more
doaj   +1 more source

Effect of Poly(L-lysine) and Heparin Coatings on the Surface of Polyester-Based Particles on Prednisolone Release and Biocompatibility

Pharmaceutics, 2021
A plethora of micro- and nanoparticle types are currently investigated for advanced ocular treatment due to improved drug retention times, higher bioavailability and better biocompatibility.
Abdelrahman Mohamed, Viktor Korzhikov-Vlakh, Nan Zhang, André Said, Iuliia Pilipenko, Monika Schäfer-Korting, Christian Zoschke, Tatiana Tennikova   +7 more
doaj   +1 more source

Research Progress on Alternative Methods of Skin Sensitization Test

Shiyan dongwu yu bijiao yixue, 2022
Allergic contact dermatitis is a type Ⅳ hypersensitivity reaction caused by repeated skin exposure to a substance and is a common public health problem. Traditional skin sensitization tests are based on animal experiments such as guinea pig maximum test ...
HUANG Jingyi, LI Peining, LIU Xiangmei, LIU Zhonghua, HUANG Yufeng   +4 more
doaj   +1 more source

Implementation, availability and regulatory status of an OECD accepted Reconstructed Human Epidermis model in Brazil

Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, 2018
Introduction: In 2014, Brazil has joined the growing list of countries to ban cosmetic products from being tested on animal models. The new legislation comes into force in 2019.
Rodrigo De Vecchi, Vanja Dakic, Guilherme Mattos, Anne-Sophie Rigaudeau, Veronica Oliveira, Cristina Garcia, Nathalie Alépée, José Cotovio, Charbel Bouez   +8 more
doaj   +7 more sources

A Progress Report and Roadmap for Microphysiological Systems and Organ-On-A-Chip Technologies to Be More Predictive Models in Human (Knee) Osteoarthritis

Frontiers in Bioengineering and Biotechnology, 2022
Osteoarthritis (OA), a chronic debilitating joint disease affecting hundreds of million people globally, is associated with significant pain and socioeconomic costs.
Mario Rothbauer, Mario Rothbauer, Mario Rothbauer, Eva I. Reihs, Eva I. Reihs, Eva I. Reihs, Anita Fischer, Reinhard Windhager, Reinhard Windhager, Florien Jenner, Stefan Toegel, Stefan Toegel   +11 more
doaj   +1 more source

Act on the Registration and Evaluation of Chemicals (K-REACH) and replacement, reduction or refinement best practices [PDF]

Environmental Health and Toxicology, 2016
Objectives Korea’s Act on the Registration and Evaluation of Chemicals (K-REACH) was enacted for the protection of human health and the environment in 2015.
Soojin Ha, Troy Seidle, Kyung-Min Lim
doaj   +1 more source

Alternative methods for the replacement of eye irritation testing

, 2022
S.55-67In the last decades significant regulatory attempts were made to replace, refine and reduce animal testing to assess the risk of consumer products for the human eye.
Wever, Bart de, Walles, Heike, Groeber-Becker, Florian, Schmid, Freia F., Kampik, Daniel, Kurdyn, Szymon, Lotz, Christian, Rossi, Angela   +7 more
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Mealworm (Tenebrio molitor Larvae) as an Alternative Protein Source for Monogastric Animal : A Review [PDF]

, 2020
Simple Summary Tenebrio molitor (T. molitor) larvae, known as mealworm, have been considered a good protein source for monogastric animals. They have a high quantity and quality of protein content and amino acid profile. The inclusion of T.
Hong, Jinsu, Kim, Yoo Yong, Jinsu Hong, Taehee Han, Yoo Yong Kim, Han, Taehee   +5 more
core   +1 more source