Results 1 to 10 of about 6,141 (135)

A Review on Preparation of Betulinic Acid and Its Biological Activities

Molecules, 2021
Betulinic acid, a pentacyclic triterpene, is distributed in a variety of plants, such as birch, eucalyptus and plane trees. It shows a wide spectrum of biological and pharmacological properties, such as anti-inflammatory, antibacterial, antiviral ...
Hanghang Lou, Hao Li, Shengliang Zhang, Hongyun Lu, Qihe Chen   +4 more
doaj   +3 more sources

Effect of Nanoemulsions of Betulinic Acid on the Development of Canine Mammary Tumors [PDF]

Veterinary Sciences
Mammary gland tumors in dogs are very common in clinical practice. Betulinic acid is currently a compound considered to have anticancer properties in human mammary tumors via nanoemulsions. In this study, betulinic acid nanoemulsions with a particle size
Zayra Yeretzi Amoros-Cerón, Juan Manuel Pinos-Rodríguez, Hugo Sergio García, Angélica Olivares-Muñoz, Isaac De Gasperin-López, Argel Flores-Primo   +5 more
doaj   +2 more sources

Betulinic acid and obesity-related disorders [PDF]

Frontiers in Pharmacology
The obesity epidemic is not just a health issue, it is increasingly driving a shift in the prevalence of chronic diseases, affecting 890 million adults and straining healthcare systems worldwide.
Lara Azevedo, Ricardo Ferraz, Ricardo Ferraz, Ricardo Ferraz, Mónica Vieira, Mónica Vieira, Cristina Prudêncio, Cristina Prudêncio, Sílvia Fernandes, Sílvia Fernandes, Sílvia Fernandes   +10 more
doaj   +2 more sources

Dual Modulation of Adipogenesis and Apoptosis by PPARG Agonist Rosiglitazone and Antagonist Betulinic Acid in 3T3-L1 Cells [PDF]

Biomedicines
Background/Objectives: Disruptions in adipose tissue dynamics contribute to obesity-related metabolic disorders, emphasizing the need for targeted therapies focusing on adipose tissue cells, including progenitor cells and adipocytes.
Patsawee Sriboonaied, Pornwipa Phuangbubpha, Puretat Saetan, Purin Charoensuksai, Adisri Charoenpanich   +4 more
doaj   +2 more sources

Stimulatory Effects of Oleci Acid and Fungal Elicitor on Betulinic Acid Production by Submerged Cultivation of Medicinal Mushroom Inonotus obliquus

Journal of Fungi, 2021
To evaluate the novel strategy of oleic acid and fungal elicitor (made from Aspergillus niger) to elicit betulinic acid biosynthesis in medicinal mushroom Inonotus obliquus, we conduct the stimulatory effects investigation for synthesizing betulinic acid
Hanghang Lou, Hao Li, Tianyu Wei, Qihe Chen   +3 more
doaj   +1 more source

Biochemical and mitochondrial membrane potential changes relating to betulinic acid-mediated anticancer activity in murine ascites Dalton's lymphoma

Phytomedicine Plus, 2022
Background: Betulinic acid, a naturally occurring pentacyclic triterpenoid is found in a variety of plants. A range of biological properties including anticancer activity has been reported for betulinic acid.
Anamika Bhaumik, Atanu Bhattacharjee, Surya Bali Prasad   +2 more
doaj   +1 more source

Multifunctional Roles of Betulinic Acid in Cancer Chemoprevention: Spotlight on JAK/STAT, VEGF, EGF/EGFR, TRAIL/TRAIL-R, AKT/mTOR and Non-Coding RNAs in the Inhibition of Carcinogenesis and Metastasis

Molecules, 2022
The pursual of novel anticancer molecules from natural sources has gained worthwhile appreciation, and a significant fraction of conceptual knowledge has revolutionized our understanding about heterogeneous nature of cancer. Betulinic acid has fascinated
Ammad Ahmad Farooqi, Assiya Turgambayeva, Gulnara Tashenova, Aigul Tulebayeva, Aigul Bazarbayeva, Gulnara Kapanova, Symbat Abzaliyeva   +6 more
doaj   +1 more source

Proteomic investigation into betulinic acid-induced apoptosis of human cervical cancer HeLa cells. [PDF]

PLoS ONE, 2014
Betulinic acid is a pentacyclic triterpenoid that exhibits anticancer functions in human cancer cells. This study provides evidence that betulinic acid is highly effective against the human cervical cancer cell line HeLa by inducing dose- and time ...
Tao Xu, Qiuying Pang, Dong Zhou, Aiqin Zhang, Shaman Luo, Yang Wang, Xiufeng Yan   +6 more
doaj   +1 more source

Chemopreventive effect of Betulinic acid via mTOR -Caspases/Bcl2/Bax apoptotic signaling in pancreatic cancer

BMC Complementary Medicine and Therapies, 2020
Background Pancreatic cancer is aggressive with no symptoms until the advanced stage reached. The increased resistance of pancreatic cancer to chemotherapy demonstrates a dilemma in the clinical field. Hence, it is a matter of great urgency to develop an
Yangyang Guo, Hengyue Zhu, Min Weng, Cheng Wang, Linxiao Sun   +4 more
doaj   +1 more source

Protective Role of Betulinic Acid against Cisplatin-Induced Nephrotoxicity and Its Antibacterial Potential toward Uropathogenic Bacteria

Pharmaceuticals, 2023
Acute kidney injury (AKI) is one of the major side effects of cisplatin, a remarkable anticancer agent. Therefore, there is a growing need to find an agent that could mitigate cisplatin-induced nephrotoxicity.
Fatemah A. Alherz, Engy Elekhnawy, Hend Mostafa Selim, Thanaa A. El-Masry, Aya H. El-Kadem, Ismail A. Hussein, Walaa A. Negm   +6 more
doaj   +1 more source