Results 1 to 10 of about 2,690,513 (210)

Development of betulinic acid as an agonist of TGR5 receptor using a new in vitro assay [PDF]

Drug Design, Development and Therapy, 2016
Shih-Hsiang Lo,1,2 Kai-Chung Cheng,3 Ying-Xiao Li,3,4 Chin-Hong Chang,4,5 Juei-Tang Cheng,4,6 Kung-Shing Lee7,8 1Division of Cardiology, Department of Internal Medicine, Zhongxing Branch of Taipei City Hospital, 2Department of History and Geography ...
Lo SH, Cheng KC, Li YX, Chang CH, Cheng JT, Lee KS   +5 more
doaj   +2 more sources

Anti-Inflammatory Activities of Betulinic Acid: A Review

Frontiers in Pharmacology, 2022
Inflammatory diseases have a high prevalence and has become of great interest due to the increase in life expectancy and the costs to the health care system worldwide.
José Fernando Oliveira-Costa, Cássio Santana Meira, Cássio Santana Meira, Maria Vitória Gomes das Neves, Bruna Padilha Zurita Claro Dos Reis, Milena Botelho Pereira Soares, Milena Botelho Pereira Soares   +6 more
doaj   +2 more sources

Betulinic acid ameliorates cast‐immobilized skeletal muscle atrophy but not denervation‐induced skeletal muscle atrophy

JCSM Communications
Background Terpenoids have gained attention as therapeutic agents for skeletal muscle atrophy owing to their various physiological activities. In this study, we screened four terpenoids for their therapeutic potential against muscle atrophy in cultured ...
Yuki Enoki, Yuki Kanezaki, Isamu Takahata, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
doaj   +1 more source

Heparin suppresses FoxO1/pFoxO1 signaling axis in vascular smooth muscle cells

Biochemistry and Biophysics Reports
Background: The atherosclerosis process relates to the dysfunction of different cells in the plaque microenvironment. The vascular smooth muscle cells (VSMCs) play an important role in atherosclerosis.
Nafiseh Shokri, Mohammad Elahimanesh, Masoomeh Bakhshandeh, Mohammad Najafi   +3 more
doaj   +1 more source

Constituintes químicos de licania tomentosa Benth. (Chrysobalanaceae) Chemical constituents of Licania tomentosa Benth. (Chrysobalanaceae)

Química Nova, 2008
This paper describes the chemical constituents isolated from leaves and fruits of Licania tomentosa Benth. The plant materials were successively extracted with hexane and methanol.
Rachel Oliveira Castilho, Maria Auxiliadora Coelho Kaplan   +1 more
doaj   +1 more source

Effect of 3β, hydroxy-lup-20(29)-en-28-oic acid on 7,12-Dimethylbenz(a) anthracene impaired cellular homeostasis in extrahepatic organs of Sprague Dawley rats

Journal of Xenobiotics, 2017
3β, hydroxy-lup-20(29)-en-28-oic acid (Betulinic acid), a pentacyclic lupane-type triterpene has diverse pharmacological functions both in vitro and in vivo.
Pardeep Kaur, Rajbir Kaur, Rohit Arora, Saroj Arora   +3 more
doaj   +1 more source

Isolation, Characterization, and HPTLC-Quantification of Compounds with Anticancer Potential from Loranthus Acaciae Zucc.

Separations, 2020
The cytotoxic effects of the crude extract of Loranthus acaciae Zucc. and its n-hexane, chloroform, and n-butanol fractions were assessed against three cancer cell lines using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay.
Omar M. Noman, Fahd A. Nasr, Ramzi A. Mothana, Ali S. Alqahtani, Wajhul Qamar, Abdullah A. Al-Mishari, Adnan J. Al-Rehaily, Nasir A. Siddiqui, Perwez Alam, Omer M. Almarfadi   +9 more
doaj   +1 more source

The efficacy of betulinic acid in triple-negative breast cancer

SAGE Open Medicine, 2014
Purpose: The treatment of triple-negative breast cancer remains a daunting challenge with the standard-of-care treatments eventually failing due to acquired drug resistance, toxic side effects and the presence of a deregulated immune response.
Daniel Weber, Mixia Zhang, Pengwei Zhuang, Yanjun Zhang, Janelle Wheat, Geoffrey Currie, Zaynab Al-Eisawi   +6 more
doaj   +1 more source

Beneficial effect of standardized extracts of Amorphophallus paeoniifolius tuber and its active constituents on experimental constipation in rats

Heliyon, 2020
The tubers of Amorphophallus paeoniifolius (Elephant foot yam), principally consumed as crop food and vegetables, are used in ethno-medicinal practices in mitigation of constipation and piles.
Yadu Nandan Dey, Manish M. Wanjari, Bhavana Srivastava, Dharmendra Kumar, Deepti Sharma, Jyoti Sharma, Sudesh Gaidhani   +6 more
doaj   +1 more source

Characterization and Quantification of Triterpenes in the Neotropical Medicinal Plant (Marcgraviaceae) by HPLC-APCI-MS

Natural Product Communications, 2008
A rapid, two-solvent, HPLC-APCI-MS method was developed to identify and quantify four pentacyclic triterpenes (betulinic acid, ursolic acid, α-amyrin and β-amyrin) in extracts of the neotropical medicinal plant Souroubea sympetala.
Martha Mullally, Kari Kramp, Ammar Saleem, Marco Otorola Rojas, Pablo Sanchez Vindas, Mario Garcia, Luis Poveda Alvarez, Tony Durst, Vance L. Trudeau, John T. Arnason   +9 more
doaj   +1 more source