Results 11 to 20 of about 2,513,921 (167)

Development of betulinic acid as an agonist of TGR5 receptor using a new in vitro assay [PDF]

Drug Design, Development and Therapy, 2016
Shih-Hsiang Lo,1,2 Kai-Chung Cheng,3 Ying-Xiao Li,3,4 Chin-Hong Chang,4,5 Juei-Tang Cheng,4,6 Kung-Shing Lee7,8 1Division of Cardiology, Department of Internal Medicine, Zhongxing Branch of Taipei City Hospital, 2Department of History and Geography ...
Lo SH, Cheng KC, Li YX, Chang CH, Cheng JT, Lee KS   +5 more
doaj   +2 more sources

The Presence of a Cyclohexyldiamine Moiety Confers Cytotoxicity to Pentacyclic Triterpenoids

Molecules, 2021
Pentacyclic triterpenoids oleanolic acid, ursolic acid, betulinic acid, and platanic acid were acetylated and converted into several amides 9–31; the cytotoxicity of which has been determined in sulforhodamine B assays employing seral human tumor cell ...
Sophie Hoenke, Martin A. Christoph, Sander Friedrich, Niels Heise, Benjamin Brandes, Hans-Peter Deigner, Ahmed Al-Harrasi, René Csuk   +7 more
doaj   +1 more source

Advancements in Betulinic Acid-Loaded Nanoformulations for Enhanced Anti-Tumor Therapy. [PDF]

Int J Nanomedicine
Ke Wang,1,2,* Jinlu Shang,3,* Chao Tao,1,2,* Mingquan Huang,4 Daiqing Wei,5 Liuxuan Yang,1 Jing Yang,1 Qingze Fan,1 Qian Ding,6 Meiling Zhou1 1Department of Pharmacy, the Affiliated Hospital, Southwest Medical University, Luzhou, People’s ...
Wang K, Shang J, Tao C, Huang M, Wei D, Yang L, Yang J, Fan Q, Ding Q, Zhou M.   +9 more
europepmc   +2 more sources

Betulinic Acid Enhances the Viability of Random-Pattern Skin Flaps by Activating Autophagy

Frontiers in Pharmacology, 2019
Random-pattern skin flap replantation is commonly used to repair skin defects during plastic and reconstructive surgery. However, flap necrosis due to ischemia and ischemia–reperfusion injury limits clinical applications.
Jiafeng Li, Jiafeng Li, Jiafeng Li, Guodong Bao, Guodong Bao, Guodong Bao, Eman ALyafeai, Jian Ding, Jian Ding, Jian Ding, Shihen Li, Shihen Li, Shihen Li, Shimin Sheng, Zitong Shen, Zhenyu Jia, Chen Lin, Chen Lin, Chen Lin, Chenxi Zhang, Chenxi Zhang, Chenxi Zhang, Zhiling Lou, Zhiling Lou, Zhiling Lou, Huazi Xu, Huazi Xu, Huazi Xu, Weiyang Gao, Weiyang Gao, Weiyang Gao, Kailiang Zhou, Kailiang Zhou, Kailiang Zhou   +33 more
doaj   +1 more source

Boosting the biosynthesis of betulinic acid and related triterpenoids in Yarrowia lipolytica via multimodular metabolic engineering

Microbial Cell Factories, 2019
Background Betulinic acid is a pentacyclic lupane-type triterpenoid and a potential antiviral and antitumor drug, but the amount of betulinic acid in plants is low and cannot meet the demand for this compound. Yarrowia lipolytica, as an oleaginous yeast,
Cong-Cong Jin, Jin-Lai Zhang, Hao Song, Ying-Xiu Cao   +3 more
doaj   +1 more source

Betulinic Acid Protects from Ischemia-Reperfusion Injury in the Mouse Retina

Cells, 2021
Ischemia/reperfusion (I/R) events are involved in the pathophysiology of numerous ocular diseases. The purpose of this study was to test the hypothesis that betulinic acid protects from I/R injury in the mouse retina.
Aytan Musayeva, Johanna C. Unkrig, Mayagozel B. Zhutdieva, Caroline Manicam, Yue Ruan, Panagiotis Laspas, Panagiotis Chronopoulos, Marie L. Göbel, Norbert Pfeiffer, Christoph Brochhausen, Andreas Daiber, Matthias Oelze, Huige Li, Ning Xia, Adrian Gericke   +14 more
doaj   +1 more source

A clickable photoaffinity probe of betulinic acid identifies tropomyosin as a target

Acta Pharmaceutica Sinica B, 2022
Target identification of bioactive compounds is important for understanding their mechanisms of action and provides critical insights into their therapeutic utility.
Pedro Martín-Acosta, Qianli Meng, John Klimek, Ashok P. Reddy, Larry David, Stefanie Kaech Petrie, Bingbing X. Li, Xiangshu Xiao   +7 more
doaj   +1 more source

Comparison of In Vitro Antimelanoma and Antimicrobial Activity of 2,3-Indolo-betulinic Acid and Its Glycine Conjugates

Plants, 2023
Malignant melanoma is one of the most pressing problems in the developing world. New therapeutic agents that might be effective in treating malignancies that have developed resistance to conventional medications are urgently required. Semisynthesis is an
Adelina Lombrea, Alexandra-Denisa Semenescu, Ioana Zinuca Magyari-Pavel, Māris Turks, Jevgeņija Lugiņina, Uldis Peipiņš, Delia Muntean, Cristina Adriana Dehelean, Stefania Dinu, Corina Danciu   +9 more
doaj   +1 more source

Betulinic acid may modulate autophagy in renal cell carcinoma cells

, 2023
OBJECTIVES: Betulinic acid is pentacyclic triterpenoid known to exert antitumor effects by modulating many cellular pathways in various human malignancies. However, its modulatory role in autophagy in renal cell carcinoma remains unclear.
ÇAKMAKOĞLU, Bedia, Iplik, Elif Sinem, ERGEN, Hayriye Arzu, ERTUĞRUL, Barış, Atas, Merve Nur   +4 more
core   +1 more source

Betulinic Acid and its Anticancer Effects

Experimed, 2020
In recent years, interest in naturally occurring compounds in plants has been increasing. Due to the benefits of these compounds, various studies have been carried out for their therapeutic use in cancer treatment as well as in daily use.
Merve Nur Ataş, Hayriye Arzu Ergen
doaj   +1 more source