Results 11 to 20 of about 6,141 (135)

The Presence of a Cyclohexyldiamine Moiety Confers Cytotoxicity to Pentacyclic Triterpenoids

Molecules, 2021
Pentacyclic triterpenoids oleanolic acid, ursolic acid, betulinic acid, and platanic acid were acetylated and converted into several amides 9–31; the cytotoxicity of which has been determined in sulforhodamine B assays employing seral human tumor cell ...
Sophie Hoenke, Martin A. Christoph, Sander Friedrich, Niels Heise, Benjamin Brandes, Hans-Peter Deigner, Ahmed Al-Harrasi, René Csuk   +7 more
doaj   +1 more source

Betulinic Acid Enhances the Viability of Random-Pattern Skin Flaps by Activating Autophagy

Frontiers in Pharmacology, 2019
Random-pattern skin flap replantation is commonly used to repair skin defects during plastic and reconstructive surgery. However, flap necrosis due to ischemia and ischemia–reperfusion injury limits clinical applications.
Jiafeng Li, Jiafeng Li, Jiafeng Li, Guodong Bao, Guodong Bao, Guodong Bao, Eman ALyafeai, Jian Ding, Jian Ding, Jian Ding, Shihen Li, Shihen Li, Shihen Li, Shimin Sheng, Zitong Shen, Zhenyu Jia, Chen Lin, Chen Lin, Chen Lin, Chenxi Zhang, Chenxi Zhang, Chenxi Zhang, Zhiling Lou, Zhiling Lou, Zhiling Lou, Huazi Xu, Huazi Xu, Huazi Xu, Weiyang Gao, Weiyang Gao, Weiyang Gao, Kailiang Zhou, Kailiang Zhou, Kailiang Zhou   +33 more
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Betulinic Acid Protects from Ischemia-Reperfusion Injury in the Mouse Retina

Cells, 2021
Ischemia/reperfusion (I/R) events are involved in the pathophysiology of numerous ocular diseases. The purpose of this study was to test the hypothesis that betulinic acid protects from I/R injury in the mouse retina.
Aytan Musayeva, Johanna C. Unkrig, Mayagozel B. Zhutdieva, Caroline Manicam, Yue Ruan, Panagiotis Laspas, Panagiotis Chronopoulos, Marie L. Göbel, Norbert Pfeiffer, Christoph Brochhausen, Andreas Daiber, Matthias Oelze, Huige Li, Ning Xia, Adrian Gericke   +14 more
doaj   +1 more source

Boosting the biosynthesis of betulinic acid and related triterpenoids in Yarrowia lipolytica via multimodular metabolic engineering

Microbial Cell Factories, 2019
Background Betulinic acid is a pentacyclic lupane-type triterpenoid and a potential antiviral and antitumor drug, but the amount of betulinic acid in plants is low and cannot meet the demand for this compound. Yarrowia lipolytica, as an oleaginous yeast,
Cong-Cong Jin, Jin-Lai Zhang, Hao Song, Ying-Xiu Cao   +3 more
doaj   +1 more source

A clickable photoaffinity probe of betulinic acid identifies tropomyosin as a target

Acta Pharmaceutica Sinica B, 2022
Target identification of bioactive compounds is important for understanding their mechanisms of action and provides critical insights into their therapeutic utility.
Pedro Martín-Acosta, Qianli Meng, John Klimek, Ashok P. Reddy, Larry David, Stefanie Kaech Petrie, Bingbing X. Li, Xiangshu Xiao   +7 more
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Isolation of Betulinic Acid, its Methyl Ester and Guaiane Sesquiterpenoids with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Roots of Saussurea lappaC.B.Clarke

Molecules, 2009
Activity-guided fractionation of a MeOH extract of the roots of Saussurea lappa C.B.Clarke (Compositae), using an in vitro protein tyrosine phosphatase 1B (PTP1B) inhibition assay, led to the isolation of four active constituents: betulinic acid (1 ...
MinKyun Na, In Hyun Hwang, Seung Ho Lee, Eun Young Bae, Bo Yeon Kim, Jong Seog Ahn, Ji Young Choi   +6 more
doaj   +1 more source

Comparison of In Vitro Antimelanoma and Antimicrobial Activity of 2,3-Indolo-betulinic Acid and Its Glycine Conjugates

Plants, 2023
Malignant melanoma is one of the most pressing problems in the developing world. New therapeutic agents that might be effective in treating malignancies that have developed resistance to conventional medications are urgently required. Semisynthesis is an
Adelina Lombrea, Alexandra-Denisa Semenescu, Ioana Zinuca Magyari-Pavel, Māris Turks, Jevgeņija Lugiņina, Uldis Peipiņš, Delia Muntean, Cristina Adriana Dehelean, Stefania Dinu, Corina Danciu   +9 more
doaj   +1 more source

In silico studies of anti-oxidative and hot temperament-based phytochemicals as natural inhibitors of SARS-CoV-2 Mpro.

PLoS ONE, 2023
Main protease (Mpro) of SARS-CoV-2 is considered one of the key targets due to its role in viral replication. The use of traditional phytochemicals is an important part of complementary/alternative medicine, which also accompany the concept of ...
Ramin Naderi Beni, Parisa Elyasi-Ebli, Sajjad Gharaghani, Arefeh Seyedarabi   +3 more
doaj   +1 more source

Optimization of Enzymatic Synthesis of Betulinic Acid Amide in Organic Solvent by Response Surface Methodology (RSM)

Indonesian Journal of Chemistry, 2019
Optimization of the lipase catalyzed enzymatic synthesis of betulinic acid amide in the presence of immobilized lipase, Novozym 435 from Candida antartica as a biocatalyst was studied.
Nurul Atikah Amin Yusof, Nursyamsyila Mat Hadzir, Siti Efliza Ashari, Nor Suhaila Mohamad Hanapi, Rossuriati Dol Hamid   +4 more
doaj   +1 more source

Evaluation of Betulin and Betulinic Acid Content in Birch Bark from Different Forestry Areas of Western Carpathians

Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2012
In order to evaluate the content of betulin and betulinic acids in Birch barks originating from Western Carpathians, Transylvania (Romania) forests, in relation with the location of birch trees, it was recorded the geographic and vegetation conditions at
Liviu HOLONEC, Floricuta RANGA, Diana CRAINIC, Alina TRUTA, Carmen SOCACIU   +4 more
doaj   +1 more source