Results 41 to 50 of about 6,141 (135)

Heparin suppresses FoxO1/pFoxO1 signaling axis in vascular smooth muscle cells

Biochemistry and Biophysics Reports
Background: The atherosclerosis process relates to the dysfunction of different cells in the plaque microenvironment. The vascular smooth muscle cells (VSMCs) play an important role in atherosclerosis.
Nafiseh Shokri, Mohammad Elahimanesh, Masoomeh Bakhshandeh, Mohammad Najafi   +3 more
doaj   +1 more source

Effect of 3β, hydroxy-lup-20(29)-en-28-oic acid on 7,12-Dimethylbenz(a) anthracene impaired cellular homeostasis in extrahepatic organs of Sprague Dawley rats

Journal of Xenobiotics, 2017
3β, hydroxy-lup-20(29)-en-28-oic acid (Betulinic acid), a pentacyclic lupane-type triterpene has diverse pharmacological functions both in vitro and in vivo.
Pardeep Kaur, Rajbir Kaur, Rohit Arora, Saroj Arora   +3 more
doaj   +1 more source

Organoids: From Bench to Bedside Applications

MedComm, Volume 7, Issue 6, June 2026.
Organoids, as a groundbreaking biomedical research platform, utilize adult stem cells (ASCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) as sources. By integrating specific growth and differentiation signals within an extracellular matrix (e.g., Matrigel), organoids guide cells to self‐assemble into three‐dimensional ...
Kelin Li, Rui Cao, Maochen Li, Zichao Tian, Huahao Fan, Bixia Hong, Xiaojuan Liu   +6 more
wiley   +1 more source

Isolation, Characterization, and HPTLC-Quantification of Compounds with Anticancer Potential from Loranthus Acaciae Zucc.

Separations, 2020
The cytotoxic effects of the crude extract of Loranthus acaciae Zucc. and its n-hexane, chloroform, and n-butanol fractions were assessed against three cancer cell lines using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay.
Omar M. Noman, Fahd A. Nasr, Ramzi A. Mothana, Ali S. Alqahtani, Wajhul Qamar, Abdullah A. Al-Mishari, Adnan J. Al-Rehaily, Nasir A. Siddiqui, Perwez Alam, Omer M. Almarfadi   +9 more
doaj   +1 more source

Nanoencapsulation of Essential Oils: A Review of Current Trends and Advances in Preparation, Characterization, and Biomedical Applications

Nano Select, Volume 7, Issue 6, June 2026.
This review highlights nanoencapsulation as a powerful strategy to improve the stability, solubility, and bioavailability of essential oils. It surveys key EO‐producing plant families, major bioactive constituents, and therapeutic properties, alongside high‐ and low‐energy nanoformulation methods. Applications across pharmaceutical, cosmetic, food, and
Mateusz Guz, Awatif Belkhiri‐Baines, Krzysztof Szczepanowicz, Anna Trybala   +3 more
wiley   +1 more source

Harnessing Phytochemicals for Brain Cancer Therapy: Insights Into Medulloblastoma and Glioblastoma Treatment

Phytochemical Analysis, Volume 37, Issue 4, Page 507-535, June 2026.
ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek, Mesra Aktas, Hale Saybasili, Kutlu O. Ulgen   +3 more
wiley   +1 more source

The efficacy of betulinic acid in triple-negative breast cancer

SAGE Open Medicine, 2014
Purpose: The treatment of triple-negative breast cancer remains a daunting challenge with the standard-of-care treatments eventually failing due to acquired drug resistance, toxic side effects and the presence of a deregulated immune response.
Daniel Weber, Mixia Zhang, Pengwei Zhuang, Yanjun Zhang, Janelle Wheat, Geoffrey Currie, Zaynab Al-Eisawi   +6 more
doaj   +1 more source

Phytochemicals in Asthma Management: Mechanism, Translational Gap and Clinical Integration

Phytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.
The phytochemicals including flavonoids, alkaloids, terpenoids, and saponins modulate inflammatory, oxidative, and immune pathways in asthma. It highlights their mechanisms of action, translational challenges, advanced formulation strategies, and emerging clinical potential as adjunct therapies for precision‐based asthma management.
Pulak Majumder, Trisita Majumder
wiley   +1 more source

Analysis of BpbHLH Gene Family Responsive to MeJA Signalling in Betula platyphylla Suk. and Functional Mechanisms of BpbHLH42/44 in Genetic Improvement and Triterpenoid Biosynthesis

Plant Biotechnology Journal, Volume 24, Issue 6, Page 4342-4357, June 2026.
ABSTRACT The basic helix–loop–helix (bHLH) transcription factor family regulates plant secondary metabolism, development and stress responses. Although triterpenoids such as betulinic acid (BA), betulin (BT) and oleanolic acid (OA) from Betula platyphylla Suk.
Ying Li, Linlin Xu, Jiale Cui, Siyao Wang, Yige Yuan, Changyixin Xiao, Xiaozhou Luo, Dmitry Baleev, Yaguang Zhan, Jing Yin   +9 more
wiley   +1 more source

Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience

Advanced Healthcare Materials, Volume 15, Issue 18, 15 May 2026.
Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram, Vanessa Arnold, Maik Wolfram‐Schauerte, Anastassiya Moskalchuk, Caroline Trust, Marie Vontz, Mona Scheurenbrand, Vijayasarathy Sampath‐Kumar, Sogand Ahari, Carlos Romero‐Nieto, Lisa Sevenich   +10 more
wiley   +1 more source