Results 21 to 30 of about 6,141 (135)

Synthesis, Characterization of Liposomes Modified with Biosurfactant MEL-A Loading Betulinic Acid and Its Anticancer Effect in HepG2 Cell

Molecules, 2019
As a novel natural compound delivery system, liposomes are capable of incorporating lipophilic bioactive compounds with enhanced compound solubility, stability and bioavailability, and have been successfully translated into real-time clinical ...
Qin Shu, Jianan Wu, Qihe Chen
doaj   +1 more source

Betulinic Acid Suppresses Ovarian Cancer Cell Proliferation through Induction of Apoptosis

Biomolecules, 2019
Ovarian cancer is one of the leading causes of cancer deaths worldwide in women, and the most malignant cancer among the different gynecological cancers.
Dahae Lee, Seoung Rak Lee, Ki Sung Kang, Yuri Ko, Changhyun Pang, Noriko Yamabe, Ki Hyun Kim   +6 more
doaj   +1 more source

Comparision of the Cytotoxic Effects of Birch Bark Extract, Betulin and Betulinic Acid Towards Human Gastric Carcinoma and Pancreatic Carcinoma Drug-sensitive and Drug-Resistant Cell Lines

Molecules, 2009
Betulin and betulinic acid are naturally occurring pentacyclic triterpenes showing cytotoxicity towards a number of cancer cell lines. These compounds can be found in the bark of the many plants.
Hermann Lage, Józef Oleksyszyn, Malgorzata Drag-Zalesinska, Manfred Dietel, Pawel Surowiak, Marcin Drag   +5 more
doaj   +1 more source

Betulinic acid analogs inhibit N- and T-type voltage-gated calcium channels to attenuate nerve-injury associated neuropathic and formalin models of pain

Neurobiology of Pain, 2023
Over the past three decades, there has been a significant growth in the use of natural products, with approximately 80% of individuals using them for some aspect of primary healthcare.
Aida Calderon-Rivera, Kimberly Gomez, Santiago Loya-López, E.M. Kithsiri Wijeratne, Harrison Stratton, Cheng Tang, Paz Duran, Kyleigh Masterson, Omar Alsbiei, A.A. Leslie Gunatilaka, Rajesh Khanna   +10 more
doaj   +1 more source

Chitosan‐Carbon Dot Composite Materials Form a Leaf Surface Barrier to Mitigate the Enrichment and Invasion of Nanoplastics: From Leaf Interface to Systemic Response

Advanced Science, EarlyView.
Foliar spraying of CS‐CDs can form a film on the leaves of Brassica rapa, effectively reducing the enrichment and absorption of PS in the leaves, while increasing the biomass and nutrient content of the plants. In addition, CS‐CDs can also enrich the interfoliar microbial community and activate the plant's own defense metabolic pathways.
Beibei Zhao, Mei Li, Mengjiao Fan, Chuanhuan Liu, Jie Jiang, Jia Song, Yingzhu Liu   +6 more
wiley   +1 more source

Comparison of Different Strains of for Hairy Root Induction and Betulin and Betulinic Acid Production in

Natural Product Communications, 2017
Three Agrobacterium rhizogenes strains were tested for their ability to transform the plant Morus alba L. and to induce production of the secondary metabolites betulin and betulinic acid. All the tested strains of A. rhizogenes (R1601, LBA9402 and R1000)
Chang Ha Park, Shicheng Zhao, Hyeon Ji Yeo, Ye Eun Park, Thanislas Bastin Baska, Mariadhas Valan Arasu, Naif Abdullah Al-Dhabi, Sang Un Park   +7 more
doaj   +1 more source

Betulinic Acid Enema Alleviates Colitis by Targeting Vitamin D Receptor to Protect the Intestinal Mucosal Barrier and Modulate Mucosa‐Associated Microbiota

Phytotherapy Research, EarlyView.
ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory disease of the colon with limited effectiveness and safety of current drug therapies. Betulinic acid (BA) is a naturally occurring pentacyclic triterpenoid present in traditional Chinese medicines used clinically as retention enemas for UC, but its direct effects and mechanisms remain unclear ...
Lina Dong, Yuanxia Gao, Qian Li, Guangxin Chen, Dong Yang, Liping Zhao, Xiaojing Liu, Shumei Lin   +7 more
wiley   +1 more source

Anti-snake venom and analgesic activities of extracts and betulinic and oleanolic acids isolated from Parinari curatellifolia

Journal of Medicinal Plants for Economic Development, 2020
Background: Parinari curatellifolia is used in Nigeria by traditional medicine practitioners (TMPs) for the treatment of snakebite and other conditions.
Emmanuel Mshelia Halilu, Natasha October, Chinenye J. Ugwah-Oguejiofor, Amina Yusuf Jega, Mathias Sylvester Nefai   +4 more
doaj   +1 more source

Advances in large DNA fragment assembly for microbial cell factory engineering

Quantitative Biology, Volume 14, Issue 3, September 2026.
Abstract The efficient, rapid, and reliable assembly of DNA fragments is essential for advancing metabolic engineering and synthetic biology. With the rapid advancement of DNA synthesis and assembly technologies, the scale of DNA assembly has expanded from single genes to metabolic pathways and even genomes.
Yu Zhang, Wenqian Liu, Dongyuan Cheng, Jiazhang Lian, Xian Fu, Yue Shen   +5 more
wiley   +1 more source

Antibacterial activities of triterpenoidal compounds isolated from Calothamnus quadrifidus leaves

BMC Complementary and Alternative Medicine, 2019
Background Calothamnus quadrifidus R.Br has many traditional uses and there are few reports about its chemical and biological activities. So our aim is to isolate the triterpenoidal compounds from dichloromethane fraction (DCMF) of Calothamnus ...
H. A. Ibrahim, M. R. Elgindi, R. R. Ibrahim, D. G. El-Hosari   +3 more
doaj   +1 more source