Results 21 to 30 of about 2,690,513 (210)

Proteomic investigation into betulinic acid-induced apoptosis of human cervical cancer HeLa cells. [PDF]

PLoS ONE, 2014
Betulinic acid is a pentacyclic triterpenoid that exhibits anticancer functions in human cancer cells. This study provides evidence that betulinic acid is highly effective against the human cervical cancer cell line HeLa by inducing dose- and time ...
Tao Xu, Qiuying Pang, Dong Zhou, Aiqin Zhang, Shaman Luo, Yang Wang, Xiufeng Yan   +6 more
doaj   +1 more source

Protective Role of Betulinic Acid against Cisplatin-Induced Nephrotoxicity and Its Antibacterial Potential toward Uropathogenic Bacteria

Pharmaceuticals, 2023
Acute kidney injury (AKI) is one of the major side effects of cisplatin, a remarkable anticancer agent. Therefore, there is a growing need to find an agent that could mitigate cisplatin-induced nephrotoxicity.
Fatemah A. Alherz, Engy Elekhnawy, Hend Mostafa Selim, Thanaa A. El-Masry, Aya H. El-Kadem, Ismail A. Hussein, Walaa A. Negm   +6 more
doaj   +1 more source

Chemopreventive effect of Betulinic acid via mTOR -Caspases/Bcl2/Bax apoptotic signaling in pancreatic cancer

BMC Complementary Medicine and Therapies, 2020
Background Pancreatic cancer is aggressive with no symptoms until the advanced stage reached. The increased resistance of pancreatic cancer to chemotherapy demonstrates a dilemma in the clinical field. Hence, it is a matter of great urgency to develop an
Yangyang Guo, Hengyue Zhu, Min Weng, Cheng Wang, Linxiao Sun   +4 more
doaj   +1 more source

The Presence of a Cyclohexyldiamine Moiety Confers Cytotoxicity to Pentacyclic Triterpenoids

Molecules, 2021
Pentacyclic triterpenoids oleanolic acid, ursolic acid, betulinic acid, and platanic acid were acetylated and converted into several amides 9–31; the cytotoxicity of which has been determined in sulforhodamine B assays employing seral human tumor cell ...
Sophie Hoenke, Martin A. Christoph, Sander Friedrich, Niels Heise, Benjamin Brandes, Hans-Peter Deigner, Ahmed Al-Harrasi, René Csuk   +7 more
doaj   +1 more source

Betulinic Acid Enhances the Viability of Random-Pattern Skin Flaps by Activating Autophagy

Frontiers in Pharmacology, 2019
Random-pattern skin flap replantation is commonly used to repair skin defects during plastic and reconstructive surgery. However, flap necrosis due to ischemia and ischemia–reperfusion injury limits clinical applications.
Jiafeng Li, Jiafeng Li, Jiafeng Li, Guodong Bao, Guodong Bao, Guodong Bao, Eman ALyafeai, Jian Ding, Jian Ding, Jian Ding, Shihen Li, Shihen Li, Shihen Li, Shimin Sheng, Zitong Shen, Zhenyu Jia, Chen Lin, Chen Lin, Chen Lin, Chenxi Zhang, Chenxi Zhang, Chenxi Zhang, Zhiling Lou, Zhiling Lou, Zhiling Lou, Huazi Xu, Huazi Xu, Huazi Xu, Weiyang Gao, Weiyang Gao, Weiyang Gao, Kailiang Zhou, Kailiang Zhou, Kailiang Zhou   +33 more
doaj   +1 more source

Boosting the biosynthesis of betulinic acid and related triterpenoids in Yarrowia lipolytica via multimodular metabolic engineering

Microbial Cell Factories, 2019
Background Betulinic acid is a pentacyclic lupane-type triterpenoid and a potential antiviral and antitumor drug, but the amount of betulinic acid in plants is low and cannot meet the demand for this compound. Yarrowia lipolytica, as an oleaginous yeast,
Cong-Cong Jin, Jin-Lai Zhang, Hao Song, Ying-Xiu Cao   +3 more
doaj   +1 more source

Betulinic Acid Protects from Ischemia-Reperfusion Injury in the Mouse Retina

Cells, 2021
Ischemia/reperfusion (I/R) events are involved in the pathophysiology of numerous ocular diseases. The purpose of this study was to test the hypothesis that betulinic acid protects from I/R injury in the mouse retina.
Aytan Musayeva, Johanna C. Unkrig, Mayagozel B. Zhutdieva, Caroline Manicam, Yue Ruan, Panagiotis Laspas, Panagiotis Chronopoulos, Marie L. Göbel, Norbert Pfeiffer, Christoph Brochhausen, Andreas Daiber, Matthias Oelze, Huige Li, Ning Xia, Adrian Gericke   +14 more
doaj   +1 more source

Betulinic acid may modulate autophagy in renal cell carcinoma cells

, 2023
OBJECTIVES: Betulinic acid is pentacyclic triterpenoid known to exert antitumor effects by modulating many cellular pathways in various human malignancies. However, its modulatory role in autophagy in renal cell carcinoma remains unclear.
ÇAKMAKOĞLU, Bedia, Iplik, Elif Sinem, ERGEN, Hayriye Arzu, ERTUĞRUL, Barış, Atas, Merve Nur, Merve Nur ATAS, Bedia CAKMAKOGLU, Elif Sinem IPLIK, Arzu ERGEN, Baris ERTUGRUL   +9 more
core   +1 more source

A clickable photoaffinity probe of betulinic acid identifies tropomyosin as a target

Acta Pharmaceutica Sinica B, 2022
Target identification of bioactive compounds is important for understanding their mechanisms of action and provides critical insights into their therapeutic utility.
Pedro Martín-Acosta, Qianli Meng, John Klimek, Ashok P. Reddy, Larry David, Stefanie Kaech Petrie, Bingbing X. Li, Xiangshu Xiao   +7 more
doaj   +1 more source

Comparison of In Vitro Antimelanoma and Antimicrobial Activity of 2,3-Indolo-betulinic Acid and Its Glycine Conjugates

Plants, 2023
Malignant melanoma is one of the most pressing problems in the developing world. New therapeutic agents that might be effective in treating malignancies that have developed resistance to conventional medications are urgently required. Semisynthesis is an
Adelina Lombrea, Alexandra-Denisa Semenescu, Ioana Zinuca Magyari-Pavel, Māris Turks, Jevgeņija Lugiņina, Uldis Peipiņš, Delia Muntean, Cristina Adriana Dehelean, Stefania Dinu, Corina Danciu   +9 more
doaj   +1 more source