Results 151 to 160 of about 60,239 (217)

Antioxidant, anticoccidial, and toxicological evaluation of Ocimum gratissimum and Vernonia amygdalina leaf extracts against Eimeria spp. [PDF]

Sci Rep
Konmy B, Dansou CC, Dègla L, Rodrigue T, Adoho ACC, Alowanou GG, Azando EVB, Allou SD, Hornick JL, Adoté-Hounzangbé SH, Moussa LB, Olounladé PA.   +11 more
europepmc   +1 more source

A Review on Current Challenges and Knowledge Gaps in Artificial Stone Silicosis

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Background The global emergence of artificial stone (AS) silicosis represents a critical occupational health challenge. The aim of this systematic review is to provide an overview of the clinical, functional, radiological, and occupational characteristics of patients affected by AS silicosis at the time of diagnosis, and to identify current ...
Paola Mason, Marco Biasioli, Filippo Liviero, Mariella Carrieri, Maria Luisa Scapellato, Vincenzo Baldo, Shivonne Prasad, Dunya Tomic, Ryan Hoy   +8 more
wiley   +1 more source

Phytochemical Profiling and Toxicological Evaluation of <i>Atraphaxis virgata</i> and <i>Atraphaxis pyrifolia</i> Extracts Using GC-MS and LC-MS. [PDF]

Molecules
Dauletova MD, Umbetova AK, Kabdraisova AZ, S Iminova R, Burasheva GS, Litvinenko YA, Yelibayeva NS, Kurbatova NV, Korul'kin DY, Ibragimova NA, Bugubaeva GO, Zhumabayev MR.   +11 more
europepmc   +1 more source

Construction Trade Work Is Associated With Accelerated Decline in Kidney Function

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Background Construction workers are exposed to airborne particulates, organic solvents, and metals—agents linked to elevated risk of chronic kidney disease (CKD). Few studies have evaluated whether construction trade work is associated with longitudinal changes in estimated glomerular filtration rate (eGFR), a key indicator of kidney function.
Sammy Almashat, John M. Dement, Marianne Cloeren, Knut Ringen, Miles Fisher, Richard Rinehart   +5 more
wiley   +1 more source

Preliminary Toxicological Evaluation of Spherical Nanoparticles Containing an Imidazole Derivative (BzIm-DEA) Using the CAM Chicken Model. [PDF]

Int J Mol Sci
Duda D, Grzegorzewska AK, Khachatryan K, Khachatryan L, Michalski O, Hovhannisyan AA, Tosunyan S, Topuzyan V.   +7 more
europepmc   +1 more source

1,2‐propanediol reformulation improves tribromoethanol safety and reveals pontine GABRA1 enrichment as a candidate mechanistic correlate of anesthesia

Animal Models and Experimental Medicine, EarlyView.
This study develops a reformulated tribromoethanol (TBE) anesthetic using 1,2‐propanediol as a solvent to overcome solvent‐related toxicity. The novel formulation demonstrates, cardiovascular stability, and survival in prolonged protocols. It provides potent, dose‐dependent anesthesia without strain or sex differences.
Xia Li, Yanming Chen, Xinyi Xiao, Guoheng Xu   +3 more
wiley   +1 more source

Photoactivated Platinum Complexes: Targeting Membrane Proteins and Organelles for Precision Cancer Therapy

Angewandte Chemie, EarlyView.
This review highlights an emerging anticancer approach integrating platinum agents into photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) systems, further augmented by cancer cell membrane‐ and organelle‐targeting. By directing photoactivated platinum complexes from nontargeted distribution to cancer cells or defined subcellular sites ...
Shu Chen, Qiyuan Zhou, Jiaqian Xu, Guangyu Zhu   +3 more
wiley   +2 more sources

The Development and Toxicological Evaluation of Novel Polyurethane Materials. [PDF]

Toxics
Zhang M, Luo X, Jiang M, Wen Y, Wang P, Chen P, Sun D.   +6 more
europepmc   +1 more source

Baihe Zhimu Decoction ameliorates anxious depression via PI3K/AKT/mTOR pathway‐mediated neuroprotection and inhibition of hippocampal neuronal apoptosis

Animal Models and Experimental Medicine, EarlyView.
Baihe Zhimu Decoction alleviates anxious depression‐like behaviors and protects hippocampal neurons. Chemical profiling and network pharmacology reveal multiple active components acting via the PI3K/AKT/mTOR pathway, enhancing neuronal survival and function, as confirmed by multi‐level in vitro and in vivo validation.
Yuanshan Han, Kexin He, Haolan Yang, Jiacheng Dai, Ronglin Chen, Yang Liu, Yuhong Wang, Lin Tang, Hongqing Zhao   +8 more
wiley   +1 more source

Accessibility and Alignment of Trans‐Cleavage Substrates Modulate the Kinetics of Cas12a Ribonucleoprotein

Angewandte Chemie, EarlyView.
Two key binding events that collectively determine the catalytic efficiency of trans‐cleavage: (1) the substrate passing through the gap between the REC and NUC domains, determined by Kpass, and (2) the alignment of the substrate with the catalytic triad of the ribonucleoprotein, determined by Kalign.
Jianyu Hu, Wei Feng, Hongquan Zhang, X. Chris Le   +3 more
wiley   +2 more sources