Results 171 to 180 of about 53,939 (264)

Analysis and Toxicological Evaluation of Nicotine Degradants and Impurities in Oral Tobacco Products: A Case Study of on! PLUS Nicotine Pouches. [PDF]

ACS Omega
Aldeek F, Wagner K, Haase V, Sublette E, Lopez V.   +4 more
europepmc   +1 more source

Trends in 25 years of antihypertensive agent utilization in Croatia – an alert for scientific community and healthcare providers

British Journal of Clinical Pharmacology, EarlyView.
Aims Hypertension is a leading modifiable risk factor for cardiovascular mortality worldwide. This study aimed to evaluate 25‐year trends in antihypertensive agent (AHA) utilization in Croatia between 2000 and 2024. Methods We conducted a national, population‐based analysis using IMS and IQVIA pharmaceutical databases.
Andrej Belančić, Marta Kučan Štiglić, Ana Jelaković, Bojan Jelaković, Dinko Vitezić   +4 more
wiley   +1 more source

Gastroprotective, Antioxidant, Anti-Inflammatory, and Toxicological Evaluation of Stem Bark Extracts of <i>Vitellaria paradoxa</i> and <i>Parkia biglobosa</i>. [PDF]

Pharmaceuticals (Basel)
Dangnon B, Dah-Nouvlessounon D, Hoteyi SMI, Sina H, Tomescu JA, Akpo KJ, Sangare-Oumar MM, Adjanohoun A, Babalola OO, Vamanu E, Baba-Moussa L.   +10 more
europepmc   +1 more source

Using non‐linear slide decks to administer individualized problem‐based learning assessments within pharmacology education

British Journal of Clinical Pharmacology, EarlyView.
Aim Problem‐based learning (PBL) is an established approach in medical, nursing, pharmacy and veterinary medicine education. This study describes the implementation and aims to evaluate the use of non‐linear slide decks as a method to deliver PBL as individualized student assessments within pharmacology education. This approach, originally developed in
Wendy R. Francis, Nia A. Davies, Aidan Seeley   +2 more
wiley   +1 more source

Acute toxicological evaluation of bone-targeted parathyroid hormone-related peptide (PTHrP) antagonist to inhibit breast cancer metastases to bone. [PDF]

Toxicol Rep
Ponnapakkam T, Anbalagan M, Stratford RE, Zou B, Blair R, Rowan BG, Gensure R.   +6 more
europepmc   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

Toxicological evaluation of imidazo-based heterocyclic derivatives: In-vitro and in-vivo acute toxicity studies. [PDF]

Toxicol Rep
Kumar S, Singhal A, Kumar P, Jain M, Kaur M, Gupta I, Salunke DB, Pawar SV.   +7 more
europepmc   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Green synthesis and toxicological evaluation of zinc oxide nanoparticles utilizing Punica granatum fruit Peel extract: an eco-friendly approach. [PDF]

Sci Rep
Mohammadi A, Hashemi N, Ghassabzadeh M, Sharafi A, Yazdinezhad A, Danafar H.   +5 more
europepmc   +1 more source

Cost‐utility analysis of nusinersen–risdiplam switch in patients with spinal muscular atrophy in Croatia: A discrete event simulation model

British Journal of Clinical Pharmacology, EarlyView.
Introduction In recent years, the treatment of spinal muscular atrophy (SMA), a rare disease, has significantly progressed, improving patients' survival and overall quality of life. However, current SMA treatments are expensive, and some (nusinersen) are very inconvenient for patients.
Andrej Belančić, Ivana Stević, Elvira Meni Maria Gkrinia, Dinko Vitezić, Slobodan Janković   +4 more
wiley   +1 more source