Results 181 to 190 of about 53,939 (264)

Toxicological Evaluation of Kaempferol and Linearolactone as Treatments for Amoebic Liver Abscess Development in Mesocricetus auratus. [PDF]

Int J Mol Sci
Varela-Rodríguez L, Calzada F, Velázquez-Domínguez JA, Hernández-Ramírez VI, Varela-Rodríguez H, Bautista E, Herrera-Martínez M, Pichardo-Hernández DL, Castellanos-Mijangos RD, Chávez-Munguía B, Talamás-Rohana P.   +10 more
europepmc   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Toxicological evaluation of porcine bile powder in Kunming mice and Sprague-Dawley rats. [PDF]

Front Pharmacol
Wu L, Wang J, Lei J, Ge K, Qu C, Liu J, Huang F, Sun D, Chao X, Chen T, Zhao A, Jia W, Zheng X, Xie G.   +13 more
europepmc   +1 more source

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source

In vivo toxicological evaluation of 3-benzylideneindolin-2-one: antifungal activity against clinical isolates of dermatophytes. [PDF]

BMC Pharmacol Toxicol
Rajakulasooriya RSR, Fernando SSN, Gunasekara TDCP, Jayaweera PM, Kumarasinghe KGUR, Thabrew HHPMJ, Chan E, Buddhika RBJ, Weerasinghe GGYH, Karunarathna KAAU.   +9 more
europepmc   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Toxicological Evaluation of a Polyherbal Formulation (18KHT01) and Validation of UPLC-DAD Method for Quality Control. [PDF]

Biomed Res Int
Pandeya PR, Lamichhane R, Lamichhane G, Lee KH, Jung HJ.   +4 more
europepmc   +1 more source

Ocrelizumab‐induced colitis: VigiBase disproportionality analysis, case reports and literature review

British Journal of Clinical Pharmacology, EarlyView.
Aims Ocrelizumab is a humanized anti‐CD20 monoclonal antibody used in multiple sclerosis. Since its commercialization, several cases of ocrelizumab‐induced colitis have been reported in the scientific literature. Methods To explore the potential association of ocrelizumab with colitis as an adverse drug reaction (ADR), we conducted a descriptive and ...
Audrey Fresse, Christophe Hommel, Nadine Petitpain, Philippe Kerschen   +3 more
wiley   +1 more source

Phytochemical Profile, Vasodilatory and Biphasic Effects on Intestinal Motility, and Toxicological Evaluation of the Methanol and Dichloromethane Extracts from the Aerial Parts of <i>Ipomoea purpurea</i> Used in Traditional Mexican Medicine. [PDF]

Pharmaceuticals (Basel)
Sánchez-Hernández V, Luna-Vázquez FJ, Carbajo-Mata MA, Ibarra-Alvarado C, Rojas-Molina A, Maruri-Aguilar B, Vázquez-Landaverde PA, Rojas-Molina I.   +7 more
europepmc   +1 more source