Results 201 to 210 of about 53,939 (264)

Mapping opioid exposure through prescription data and postmortem analysis of opioid drugs in multiple tissues

British Journal of Clinical Pharmacology, EarlyView.
Background and Purpose Although opioids are central to end of life (EoL) care, tissue‐level opioid exposure remains poorly understood. The objective of this study was to characterize the relationship between prescription‐derived morphine equivalent daily dose (MEDD) and measured morphine concentrations across multiple organs.
Niamh Higgins, Alan Wells, Nimish Patel, Nicole Muttera, Mattia Trunfio, Alessandra Manca, Amedeo De Nicolò, Micol Ferrara, Stefano Bonora, Jessica Cusato, Alice Palermiti, Antonio D'Avolio, Marissa Borochoff, Patricia K. Riggs, Elizabeth Hastie, Rabia S. Atayee, Stephanie Solso, Cheryl Dullano, Vanessa Gomez‐Moreno, Tara Tenenbaum, Robert Deiss, Davey M. Smith, Antoine Chaillon, Sara Gianella   +23 more
wiley   +1 more source

Retraction notice to "Environmental impacts of COVID-19 treatment: Toxicological evaluation of azithromycin and hydroxychloroquine in adult zebrafish" [Sci. Total Environ. 790(2021) 148129]. [PDF]

Sci Total Environ
Mendona-Gomes JM, da Costa Arajo AP, da Luz TM, Charlie-Silva I, Braz HLB, Jorge RJB, Ahmed MAI, Nbrega RH, Vogel CFA, Malafaia G.   +9 more
europepmc   +1 more source

Quantitative prediction of intravenous drug interactions caused by cytochromes P450 inhibitors and inducers

British Journal of Clinical Pharmacology, EarlyView.
Background Aims Pharmacokinetic interaction studies typically focus on oral administration, but intravenous (IV) administration bypasses intestinal degradation and hepatic first‐pass metabolism, leading to distinct drug–drug interaction (DDI) magnitude. This study aimed to develop a predictive model for DDIs involving IV‐administered drugs.
Vianney Tuloup, Michel Tod, Laurent Bourguignon   +2 more
wiley   +1 more source

Automated Radiosynthesis of [¹⁸F]FluoFAPI and Its Dosimetry and Single Acute Dose Toxicological Evaluation. [PDF]

Pharmaceuticals (Basel)
Witek JA, Brooks AF, Kapila SM, Winton WP, Stauff JR, Scott PJH, Viglianti BL.   +6 more
europepmc   +1 more source

Toxicological evaluation of microbial secondary metabolites in the context of European active substance approval for plant protection products. [PDF]

Environ Health
Paege N, Feustel S, Marx-Stoelting P.
europepmc   +1 more source

Biomimetic green synthesis of ZnO nanoflowers using α-amylase: from antimicrobial to toxicological evaluation. [PDF]

Sci Rep
Mazumder JA, Ahmad A, Ali J, Noori R, Bhuyan T, Sardar M, Sheehan D.   +6 more
europepmc   +1 more source

Toxicological Evaluation toward Refined Montmorillonite with Human Colon Associated Cells and Human Skin Associated Cells. [PDF]

J Funct Biomater
Wang Z, Jiang Y, Tian G, Zhu C, Zhang Y.
europepmc   +1 more source

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A toxicological evaluation of geranylgeraniol

Regulatory Toxicology and Pharmacology, 2021
Geranylgeraniol (GGOH) is an isoprenoid compound found in annatto seeds and an intermediate of the mevalonate pathway found within organisms serving various functions. Toxicological studies on its safety profile are not readily available. To assess the safety of GGOH, a molecularly distilled, food grade annatto oil, consisting of approximately 80 ...
Kayla Preece, Róbert Glávits, John R. Foster, Timothy Murbach, John R. Endres, Gábor Hirka, Adél Vértesi, Erzsébet Béres, Ilona Pasics Szakonyiné   +8 more
openaire   +2 more sources

Toxicological evaluation of myristicin

Natural Toxins, 1997
AbstractMyristicin, or methoxysafrole, is the principal aromatic constituent of the volatile oil of nutmeg, the dried ripe seed of Myristica fragrans. Myristicin is also found in several members of the carrot family (Umbelliferae). Several intoxications have been reported after an ingestion of approximately 5 g of nutmeg, corresponding to 1–2 mg ...
H, Hallström, A, Thuvander
openaire   +2 more sources