Results 211 to 220 of about 53,939 (264)

Toxicologic evaluation of Yessotoxin

Natural Toxins, 1997
Yessotoxin (YTX), originally found in association with diarrhetic shellfish poisoning (DSP), caused neither intestinal fluid accumulation nor inhibition of protein phosphatase 2A. Orally, YTX was not lethal to mice at 1.0 mg/kg. The toxin showed weak cytotoxic and antifungal activities. Neither hemolytic nor ichthyotoxic effect was observed.
H, Ogino, M, Kumagai, T, Yasumoto
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Toxicological evaluation of cyclosporin A

Archives of Toxicology, 1983
Toxicological studies in a variety of different animal species have shown that cyclosporin A (CS-A) is a unique immunosuppressant, since it does not cause myelotoxic, teratogenic, mutagenic, or carcinogenic effects. This is undoubtedly due to the fact CS-A produces its immunosuppressive effects by a specific action on T lymphocytes rather than by a ...
B, Ryffel, P, Donatsch, M, Madörin, B E, Matter, G, Rüttimann, H, Schön, R, Stoll, J, Wilson   +7 more
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Toxicology and Evaluation of Microcystins

Therapeutic Drug Monitoring, 2000
This paper reviews the toxicity and tumor-promoting properties of microcystins. Methods for screening and/or identification of microcystins in environmental samples are discussed and compared. Specific emphasis is placed on newly developed extraction/detection methods, e.g., solid phase microextraction (SPME) technique, and capillary electrophoresis ...
P K, Lam, M, Yang, M H, Lam
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Toxicological evaluation of sobatum

Cancer Letters, 1998
Sobatum, the partially purified component of the plant Solanum trilobatum was obtained from the petroleum ether/ethyl acetate (75:25) extractable portion. It was identified as beta-sitosterol by comparison with an authentic sample and proved to be an anticancer agent by in vitro and in vivo experiments.
P V, Mohanan, K S, Devi
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Toxicological evaluation of chemical mixtures

Food and Chemical Toxicology, 2002
This paper addresses major developments in the safety evaluation of chemical mixtures during the past 15 years, reviews today's state of the art of mixture toxicology, and discusses challenges ahead. Well-thought-out tailor-made mechanistic and empirical designs for studying the toxicity of mixtures have gradually substituted trial-and-error approaches,
Feron, V.J., Groten, J.P.
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Toxicological Safety Evaluation of Gadobutrol

Investigative Radiology, 2012
Gadobutrol (Gadovist/Gadavist, Bayer Pharma AG, Berlin, Germany) is a nonionic, macrocyclic, gadolinium-based contrast agent for magnetic resonance imaging of the central nervous system as well as liver and kidneys and for contrast enhancement in magnetic resonance angiography. For risk assessment of the single diagnostic use in humans, the toxicity of
Christiane, Wack, Thomas, Steger-Hartmann, Louis, Mylecraine, Rainer, Hofmeister   +3 more
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Toxicologic evaluation of chlorpyrifos in cats

American Journal of Veterinary Research, 1988
SUMMARY Twenty-four male domestic shorthair cats were used to evaluate the acute and chronic effects of a single, toxic but sublethal, orally administered dose of chlorpyrifos. A dosage of 10 mg/kg of body weight did not induce clinical signs of toxicosis, but a dosage of 40 mg/kg induced clinical signs of toxicosis, and 1 of 12 cats died. Chlorpyrifos
S B, Hooser, V R, Beasley, J P, Sundberg, K, Harlin   +3 more
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Toxicology of gallates: A review and evaluation

Food and Chemical Toxicology, 1986
The propyl, octyl and dodecyl esters of gallic acid have been studied extensively in a large number of animal experiments involving oral dosing. Experimental data on general toxicity and studies on reproduction, teratogenicity and mutagenicity are also available.
van der Heijden, CA, Janssen, PJCMrivm, Strik, JJTWA   +2 more
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Toxicological evaluation of cyclosporine eyedrops

Acta Ophthalmologica Scandinavica, 1999
The short-term toxicological effects of two cyclosporine A eyedrop formulations are compared.Formula A was based on Sandimmune (Novartis, Switzerland) infusion concentrate with a final ethanol concentration of 1% (w/w), and formula B on Sandimmune oral solution. Both formulations were diluted in sterile peanut oil (10 mg/ml).
S K, Knagenhjelm, K, Frøyland, A, Ringvold, E, Bjerkås, I, Kjønniksen   +4 more
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Perspective on Adversity in Toxicology Evaluations

Toxicologic Pathology, 2020
Determining adversity of effects in toxicology studies continues to pose a dilemma to practicing toxicologists and pathologists. How this determination is made may follow either a focused or broad approach to assessing the study data. The choice of which approach is best is dependent on a variety of factors.
Jeffery A. Engelhardt, Michael A. Dorato
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