Results 211 to 220 of about 5,381,284 (255)

Matrix‐Activated Aptamer Sensors for Human Serum Analysis

Angewandte Chemie, EarlyView.
The sample self‐analyzes: The predominant serum proteins, albumin and immunoglobulin G, were leveraged to activate the response of fluorescent aptamer probes within the biological matrix. The fluorescence‐anisotropy‐based sensing platform demonstrated both performance and consistency for the direct detection of small molecules in serum‐rich samples ...
Amandine Barbaroux, Benoit Chovelon, Emmanuelle Fiore, Sebastien Vezirian, Mickael Henry, Marwa Zoubeidi, Maria C. DeRosa, Corinne Ravelet, Eric Peyrin   +8 more
wiley   +2 more sources

Toxicological evaluation and preliminary phytochemical characterisation of a Nigerian <i>Cannabis sativa</i> chemovar. [PDF]

Iran J Basic Med Sci
Ajagun EJ, Alabi BA, Alli-Oluwafuyi AM, Ologe MO.   +3 more
europepmc   +1 more source

Safety and Feasibility of Magnetic Separation‐Based Blood Purification

Advanced NanoBiomed Research, EarlyView.
We present the preclinical biological safety and translational feasibility of a magnetic nanoparticle‐based extracorporeal blood purification platform for removal of disease‐causing blood factors. ISO 10993‐compliant studies and exaggerated worst‐case exposure models demonstrate efficient nanoparticle extraction (≥99.9%), favorable biocompatibility ...
Carlos A. Mora, Laurine Rijsbergen, Jan Waskowski, Gaelle Clermont, Florian Dingreville, Chandrashekara Vishwanath, Rajesh Karunanithi, Alexander Gogos, Jean‐Claude Metzger, Manuel Baumgartner, Joerg C. Schefold, Inge K. Herrmann   +11 more
wiley   +1 more source

Practical Computational Exploration of Chemical Reaction Space: Assessing the Chemical Stability of Active Pharmaceutical Ingredients Under Acidic Conditions

Angewandte Chemie, EarlyView.
Metadynamics simulations drive automated reaction exploration of acid‐catalysed drug degradation, generating a network spanning 1720 species and 2471 elementary steps. QM‐based filtering reduces the network to eight candidate pathways for rigorous DFT refinement and microkinetic modelling.
Julius Seumer, Maria Harris Rasmussen, Oriana Brea, Mikko Muuronen, Andreas H. Göller, Jan H. Jensen   +5 more
wiley   +2 more sources

Toxicological evaluation, postmortem case descriptions, and pharmacological activity of N,N-dimethylpentylone and related analogs. [PDF]

J Anal Toxicol
Fogarty MF, Walton SE, Truver MT, Glatfelter GC, Krotulski AJ, Papsun DM, Lamb M, Chronister CW, Goldberger BA, Walther D, Barba K, Baumann MH, Logan BK.   +12 more
europepmc   +1 more source

Piezoelectric Nanocomposite Hydrogel for Wireless Neural Stimulation and Tissue Augmentation

Advanced NanoBiomed Research, EarlyView.
A cell/tissue supporting piezoelectric hydrogel system (PZ‐gel) that incorporates ferroelectric, pyroelectric, and piezoelectric ceramic material barium titanate into an alginate/carboxymethyl chitosan hydrogel. The PZ‐gel can be sonoactivated for wireless neural cell and tissue stimulation, with the potential to be used as a stimulatory cell substrate
Mohammad Mohammadi, Eva Tomaskovic‐Crook, Peter C. Innis, Jeremy M. Crook   +3 more
wiley   +1 more source

Photoactivated Platinum Complexes: Targeting Membrane Proteins and Organelles for Precision Cancer Therapy

Angewandte Chemie, EarlyView.
This review highlights an emerging anticancer approach integrating platinum agents into photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) systems, further augmented by cancer cell membrane‐ and organelle‐targeting. By directing photoactivated platinum complexes from nontargeted distribution to cancer cells or defined subcellular sites ...
Shu Chen, Qiyuan Zhou, Jiaqian Xu, Guangyu Zhu   +3 more
wiley   +2 more sources

Toxicological evaluation of volatile organic compounds emitted from scented candles: <i>in silico</i> ADMET profiling, oxidative stress, inflammation, and lung injury in rats. [PDF]

Front Public Health
Mohamed MS, Omran AME, Obidan A, Alsulami SO, Aljohani NB, Alshehri EH, Alfarteesh H, Aljohani NB, Ali AG.   +8 more
europepmc   +1 more source

Pharmaco-Technological Characterization, Structural Analysis, and Toxicological Evaluation of the Novel Polyene Antibiotic Roseofungin for Drug Development. [PDF]

Pharmaceutics
Sadanov A, Berillo D, Bagimbayeva A, Baimakhanova G, Ibragimova LN, Kulmaganbetov IR, Nurmaganbetova F, Sarsenbaeva G, Orazymbet S, Baimakhanova B, Lakh O, Tleubekova D, Dzhakibaeva GT, Mussaldinov T.   +13 more
europepmc   +1 more source

Acute toxicological evaluation of bone-targeted parathyroid hormone-related peptide (PTHrP) antagonist to inhibit breast cancer metastases to bone. [PDF]

Toxicol Rep
Ponnapakkam T, Anbalagan M, Stratford RE, Zou B, Blair R, Rowan BG, Gensure R.   +6 more
europepmc   +1 more source