Results 221 to 230 of about 53,939 (264)

Toxicological evaluation of hydrochlorofluorocarbon 142b

Food and Chemical Toxicology, 1986
Groups of 110 rats of each sex were exposed by whole-body inhalation to 0, 1000, 10,000 or 20,000 ppm (v/v) of hydrochlorofluorocarbon 142b (CFC 142b or 1-chloro-1, 1-difluoroethane) for 6 hr/day, 5 days/wk for 104 wk (ten rats from each group were killed after 52 wk) in a combined chronic toxicity and oncogenicity study.
J A, Seckar, H J, Trochimowicz, G K, Hogan   +2 more
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In vivo toxicological evaluation of Anisomycin

Toxicology Letters, 2012
Anisomycin is a pyrrolidine antibiotic isolated from Streptomyces griseolus. Recent studies have shown that Anisomycin as a novel immunosuppressive agent is superior to Cyclosporine A (J. Immunother. 31, 858-870, 2008). In order to make toxicological evaluation of Anisomycin, acute and four-week continuously intravenous toxicity studies were performed ...
Zhengle, Tang, Feiyue, Xing, Di, Chen, Yu, Yu, Chunyan, Yu, Jingfang, Di, Jing, Liu   +6 more
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Toxicological evaluations of colostrum ultrafiltrate

Regulatory Toxicology and Pharmacology, 2019
Colostrum has been consumed safely for many years as a food collected directly from cows. More recently, an ultrafiltrated bovine colostrum product has been developed; however, its safety in toxicology studies has not been extensively evaluated.
Anne Thiel, Róbert Glávits, Timothy S. Murbach, John R. Endres, Robin Reddeman, Gábor Hirka, Adél Vértesi, Erzsébet Béres, Ilona Pasics Szakonyiné   +8 more
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Toxicological evaluation of sodium perfluorohexanoate

Toxicology, 2009
Sodium perfluorohexanoate [NaPFHx, F(CF(2))(5)CO(2)Na, CAS#2923-26-4] was evaluated in acute, 90-day subchronic, one-generation reproduction, developmental and in vitro genetic toxicity studies. In the subchronic/one-generation reproduction study, four groups of young adult male and female Crl:CD(SD) rats were administered NaPFHx daily for ...
Scott E, Loveless, Brian, Slezak, Tessa, Serex, Joseph, Lewis, Pushkor, Mukerji, John C, O'Connor, E Maria, Donner, Steven R, Frame, Stephen H, Korzeniowski, Robert C, Buck   +9 more
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A contribution to the toxicological evaluation of hexamethylenetetramine

Food and Cosmetics Toxicology, 1971
Abstract Hexarnethylenetetramine (Hexa) has been studied in a long-term trial in which rats were fed on a diet containing 0·16% Hexa from weaning to natural death. The voluntary muscular activity, body-weight curves, lifespan, causes of death and the relative weights of major organs were compared with those of rats fed the same diet without added ...
H, Natvig, J, Andersen, E W, Rasmussen
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Preclinical toxicology studies with azithromycin: genetic toxicology evaluation

Mutation Research/Genetic Toxicology, 1993
Azithromycin was subjected to a series of three in vitro and one in vivo genetic toxicology assays for the detection of drug-associated gene or chromosomal effects. In the Ames Salmonella typhimurium tester strains TA1535, TA1537, TA98 and TA100, the presence of azithromycin was not associated with any increase in the number of his- revertants.
D E, Amacher, J H, Ellis, A J, Joyce, P A, Muehlbauer, G N, Turner, M G, Wahrenburg, H E, Holden, V A, Ray   +7 more
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Toxicological evaluation of pure hydroxytyrosol

Food and Chemical Toxicology, 2013
Of all the phenolic constituents of olives and extra virgin olive oil, hydroxytyrosol is currently being actively exploited as a potential supplement or preservative to be employed in the nutraceutical, cosmeceutical, and food industry. In terms of safety profile, hydroxytyrosol has only been investigated as the predominant part of raw olive mill waste
Auñon Calles D, Canut L, VISIOLI, FRANCESCO   +2 more
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The preclinical toxicological evaluation of sumatriptan

Human & Experimental Toxicology, 1995
1 Sumatriptan is a potent and selective 5-HT 1 receptor agonist marketed for the treatment of migraine by both oral and subcutaneous routes. An extensive toxicologi cal programme employing high doses of sumatriptan was carried out in a range of animal species.
K, Owen, K, Hartley, M L, Tucker, M M, Parkinson, D J, Tweats, M R, Jackson   +5 more
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Strategies for toxicological evaluation of mixtures

Food and Chemical Toxicology, 1996
Different strategies for the toxicological evaluation of mixtures are presented. The purpose is to determine the effects of each component (variable) in the mixture, and possible interactions between variables. The examples presented have 3-5 predictor variables and 1-3 responses, and are based on statistical experimental design, multivariate data ...
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Toxicological Evaluation of u-hEGF

Toxicologic Pathology, 1995
The toxicological evaluation of urinary human epidermal growth factor (u-hEGF) included mutagenicity, single and repeated dose general toxicity, and teratogenicity studies in various animal species. The mutagenic potential of u-hEGF was tested in vitro (Ames test, chromosome aberration in human lymphocytes, unscheduled DNA synthesis in HeLa cells) and ...
R, Maraschin, R, Bussi, A, Conz, L, Orlando, R, Pirovano, A, Nyska   +5 more
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