Results 121 to 130 of about 25,002 (218)

Production, Characterisation and Testing of an Ovine Antitoxin against Ricin; Efficacy, Potency and Mechanisms of Action

Toxins, 2017
Ricin is a type II ribosome-inactivating toxin that catalytically inactivates ribosomes ultimately leading to cell death. The toxicity of ricin along with the prevalence of castor beans (its natural source) has led to its increased notoriety and ...
Sarah J. C. Whitfield, Gareth D. Griffiths, Dominic C. Jenner, Robert J. Gwyther, Fiona M. Stahl, Lucy J. Cork, Jane L. Holley, A. Christopher Green, Graeme C. Clark   +8 more
doaj   +1 more source

Wake Me When It\u27s Over- Bacterial Toxin-Antitoxin Proteins and Induced Dormancy [PDF]

, 2016
Toxin-antitoxin systems are encoded by bacteria and archaea to enable an immediate response to environmental stresses, including antibiotics and the host immune response.
Coussens, Nathan P., Daines, Dayle A.
core   +2 more sources

The HicA toxin from Burkholderia pseudomallei has a role in persister cell formation [PDF]

, 2014
© 2014 The Authors Journal compilation. ©2014 Biochemical Society.This is an open access article that is freely available in ORE or from the publisher's website.
Aaron Butt, Ahmad, Bardiaux, Bhattacharya, Bigger, Blower, Butt, Christopher Williams, Claudia M. Hemsley, Currie, Delaglio, Doreleijers, Dörr, Fauvart, Fiebig, Gerdes, Gerdes, Goeders, Goodyear, Hayes, Heeb, Ichiyanagi, Joers, Jorgensen, Keren, Keren, Kim, Kint, Knudsen, Korch, Korch, Lazar Adler, Leung, Lewis, Lewis, Liew, Limmathurotsakul, Madigan, Maisonneuve, Makarova, Matthew P. Crump, Milton, Moker, Murzin, Nicholas Harmer, Porter, Richard W. Titball, Schuster, Sevillano, Shah, Singh, Studier, Subramaniam, Ulrich, Vega, Victoria A. Higman, Vranken, Wang, Wiersinga, Wiersinga, Yamaguchi, Zhao, Zhu   +62 more
core   +1 more source

A novel type I toxin-antitoxin system modulates persister cell formation in Staphylococcus aureus

International Journal of Medical Microbiology, 2020
A plethora of toxin-antitoxin systems exist in bacteria and has multilateral roles in bacterial pathogenesis and virulence. Toxin-antitoxin systems have been involved in persister cell formation in Escherichia coli and Mycobacterium but have not been ...
Gul Habib, Jiade Zhu, Baolin Sun
doaj  

Operator-Theoretic Characterization of Eventually Monotone Systems

, 2017
Monotone systems are dynamical systems whose solutions preserve a partial order in the initial condition for all positive times. It stands to reason that some systems may preserve a partial order only after some initial transient.
Mauroy, Alexandre, Sootla, Aivar
core   +1 more source

Artificial Activation of Escherichia coli mazEF and hipBA Toxin–Antitoxin Systems by Antisense Peptide Nucleic Acids as an Antibacterial Strategy

Frontiers in Microbiology, 2018
The search for new, non-standard targets is currently a high priority in the design of new antibacterial compounds. Bacterial toxin–antitoxin systems (TAs) are genetic modules that encode a toxin protein that causes growth arrest by interfering with ...
Marcin Równicki, Marcin Równicki, Tomasz Pieńko, Tomasz Pieńko, Jakub Czarnecki, Jakub Czarnecki, Monika Kolanowska, Monika Kolanowska, Dariusz Bartosik, Joanna Trylska   +9 more
doaj   +1 more source

Influence of diverse pH and temperatures on the gene expression of toxin-antitoxin systems in Klebsiella pneumoniae [PDF]

Background: The type II toxin-antitoxin system consists of tightly linked genetic units that produce  a toxin and its specific antitoxin. Under typical circumstances, the antitoxin  neutralizes the toxic effects caused by the toxin.
Al-Marjani, Mohammed F., Hassan, Fatima J., Khelkal, Intesar N.   +2 more
core   +2 more sources

Toxin Inactivation in Toxin/Antitoxin Systems

, 2019
Toxin/antitoxin (TA) systems are used primarily to inhibit phage, reduce metabolic activity during stress, and maintain genetic elements. Given the extreme toxicity of some of the toxins of these TA systems, we were curious how the cell silences toxins, if the antitoxin is inactivated or when toxins are obtained without antitoxins via horizontal gene ...
Laura Fernandez-Garcia, Jun-Seob Kim, Maria Tomas, Thomas K. Wood   +3 more
openaire   +3 more sources

A simple BLASTn-based approach generates novel insights into the regulation and biological function of type I toxin-antitoxins

mSystems
Bacterial chromosomal type I toxin-antitoxin systems consist of a small protein, typically under 60 amino acids, and a small RNA (sRNA) that represses toxin translation.
Selene F. H. Shore, Michael Ptacek, Andrew D. Steen, Elizabeth M. Fozo   +3 more
doaj   +1 more source

A bacterial toxin-antitoxin system as a native defence element against RNA phages. [PDF]

Biol Lett
Nikolic N, Pleška M, Bergmiller T, Guet CC.   +3 more
europepmc   +1 more source