mBio, 2019 Toxin-antitoxin (TA) systems are broadly distributed modules whose biological roles remain mostly unknown. The mqsRA system is a noncanonical TA system in which the toxin and antitoxins genes are organized in operon but with the particularity that the ...
Nathan Fraikin +3 more
doaj +1 more source
The mazEF toxin-antitoxin system as a novel antibacterial target in Acinetobacter baumannii [PDF]
, 2014 Although analysis of toxin-antitoxin (TA) systems can be instructive, to date, there is no information on the prevalence and identity of TA systems based on a large panel of Acinetobacter baumannii clinical isolates.
Ghafourian, S +6 more
core +5 more sources
A general model for toxin-antitoxin module dynamics can explain persister cell formation in E. coli. [PDF]
PLoS Computational Biology, 2013 Toxin-Antitoxin modules are small operons involved in stress response and persister cell formation that encode a "toxin" and its corresponding neutralizing "antitoxin".
Lendert Gelens +4 more
doaj +1 more source
A Primary Physiological Role of Toxin/Antitoxin Systems Is Phage Inhibition
Frontiers in Microbiology, 2020 Toxin/antitoxin (TA) systems are present in most prokaryote genomes. Toxins are almost exclusively proteins that reduce metabolism (but do not cause cell death), and antitoxins are either RNA or proteins that counteract the toxin or the RNA that encodes ...
Sooyeon Song, T. Wood
semanticscholar +1 more source
Conjugative plasmid-encoded toxin–antitoxin system PrpT/PrpA directly controls plasmid copy number
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Since conjugative plasmids are usually large and may carry genes encoding functions that are detrimental to the bacterial host, minimizing plasmid copy number is critical for reducing the host burden.
S. Ni +6 more
semanticscholar +1 more source
The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence [PDF]
, 2014 Nearly all bacteria exhibit a type of phenotypic growth described as persistence that is thought to underlie antibiotic tolerance and recalcitrant chronic infections.
Behiels, Ester +6 more
core +2 more sources
Mechanisms for Differential Protein Production in Toxin–Antitoxin Systems
Toxins, 2017 Toxin–antitoxin (TA) systems are key regulators of bacterial persistence, a multidrug-tolerant state found in bacterial species that is a major contributing factor to the growing human health crisis of antibiotic resistance. Type II TA systems consist of
Heather S. Deter +3 more
doaj +1 more source
YoeB toxin is activated during thermal stress. [PDF]
, 2015 Type II toxin-antitoxin (TA) modules are thought to mediate stress-responses by temporarily suppressing protein synthesis while cells redirect transcription to adapt to environmental change.
Garza-Sánchez, Fernando +2 more
core +1 more source
The role of small proteins in Burkholderia cenocepacia J2315 biofilm formation, persistence and intracellular growth [PDF]
, 2019 Burkholderia cenocepacia infections are difficult to treat due to resistance, biofilm formation and persistence. B. cenocepacia strain J2315 has a large multi-replicon genome (8.06 Mb) and the function of a large fraction of (conserved) hypothetical ...
Braeckmans, Kevin +12 more
core +1 more source
A widespread toxin−antitoxin system exploiting growth control via alarmone signaling
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance The alarmone (p)ppGpp is a central signaling nucleotide that is synthesized by RelA-SpoT Homologue (RSH) enzymes, and rewires bacterial physiology in response to stress. It is an unanswered question why bacteria often carry multiple (p)ppGpp-
Steffi Jimmy +13 more
semanticscholar +1 more source