Results 71 to 80 of about 18,870 (223)

Multiple Toxin-Antitoxin Systems in Mycobacterium tuberculosis [PDF]

Toxins, 2014
The hallmark of Mycobacterium tuberculosis is its ability to persist for a long-term in host granulomas, in a non-replicating and drug-tolerant state, and later awaken to cause disease. To date, the cellular factors and the molecular mechanisms that mediate entry into the persistence phase are poorly understood. Remarkably, M.
Patricia Bordes, Ambre Sala, Pierre Genevaux   +2 more
openaire   +4 more sources

Two plasmid‐borne virulence genomic islands of Clavibacter michiganensis are genetically diverse and determine the development of wilt symptoms in host plants

New Phytologist, EarlyView.
Summary Plasmids contribute to the efficient adaptation of bacteria to specific niches in nature. The gram‐positive bacterium Clavibacter michiganensis carries two plasmid‐borne important virulence genes, celA and pat‐1, necessary for wilting in tomato. The 88 C.
In Sun Hwang, Thuong Thi Nguyen, Eom‐Ji Oh, Geonhui Cho, Jea Hyeoung Kim, Ki‐Tae Kim, Yong‐Hwan Lee, You‐Kyoung Han, Chang‐Sik Oh   +8 more
wiley   +1 more source

The ζ toxin induces a set of protective responses and dormancy. [PDF]

PLoS ONE, 2012
The ζε module consists of a labile antitoxin protein, ε, which in dimer form (ε(2)) interferes with the action of the long-living monomeric ζ phosphotransferase toxin through protein complex formation.
Virginia S Lioy, Cristina Machon, Mariangela Tabone, José E Gonzalez-Pastor, Rimantas Daugelavicius, Silvia Ayora, Juan C Alonso   +6 more
doaj   +1 more source

Therapeutic Effects of Naringin on Bisphenol A‐Induced Oxidative Stress Damage in Nervous and Reproductive Systems of Cockerel Chickens

Veterinary Medicine and Science, Volume 11, Issue 4, July 2025.
ABSTRACT Background Bisphenol A (BPA) is an endocrine‐disrupting chemical, and it is mostly used in plastic industries. Naringin is a potent flavonoid that has been reported to possess several beneficial pharmacological properties such as antioxidant, anti‐inflammatory, and antiapoptotic properties.
Leah Oluwaseyanu Esuola, Oluwaseun Olarenwaju Esan, Adamu Shafiu Maikifi, Temitayo Olabisi Ajibade, Moses Olusola Adetona, Oluwasanmi Olayinka Aina, Ademola Adetokunbo Oyagabemi, Temidayo Olutayo Omobowale, Omolade Abodunrin Oladele, Evaristus Nwulia, Momoh Audu Yakubu, Oluwafemi Omoniyi Oguntibeju   +11 more
wiley   +1 more source

B Cells as a Host of Persistent Salmonella Typhimurium

Immunology, Volume 175, Issue 3, Page 292-299, July 2025.
B cells: a niche for persistent Salmonella enterica serovar Typhimurium (S. Tm). In vitro, within B cells and in the absence of antibiotics, a persistent population of S. Tm emerges, where the SehA/B gene is implicated. Additionally, a replicative population of S. Tm is also present. Upon antibiotic administration, approximately 90% of the S.
Alonso D. Cruz‐Cruz, Jocelyn C. Pérez‐Lara, Diana Z. Velázquez, Gabriela Hernández‐Galicia, Vianney Ortiz‐Navarrete   +4 more
wiley   +1 more source

The Protective Effects of Chrysin on Acrylamide‐Induced Hepatotoxicity: Insights Into Oxidative Stress, Inflammation, Apoptosis, Autophagy, and Histological Evaluation in Rats

Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 6, June 2025.
CHR exhibited significant protective effects against ACR‐induced hepatotoxicity by reducing oxidative stress, decreasing inflammation and apoptosis, and inhibiting autophagic activity, highlighting its potential as an effective therapeutic agent. ABSTRACT Acrylamide (ACR) is a toxic chemical with a high carcinogenic risk that is released as a result of
Selman Gencer, Nurhan Akaras, Hasan Şimşek, Cihan Gür, Mustafa İleritürk, Sefa Küçükler, Fatih Mehmet Kandemir   +6 more
wiley   +1 more source

Extracellular Vesicles From Xylella fastidiosa Carry sRNAs and Genomic Islands, Suggesting Roles in Recipient Cells

Journal of Extracellular Vesicles, Volume 14, Issue 6, June 2025.
ABSTRACT Xylella fastidiosa (Xf) is a Gram‐negative bacterial plant pathogen responsible for severe diseases in a variety of economically important crops. A critical aspect of its virulence is the production of extracellular vesicles (EVs). In this study, we discovered that DNA‐binding proteins and nonribosomal RNA‐binding proteins are abundant in the ...
Alessa Ruf, Patrick Blumenkamp, Christina Ludwig, Anne Lippegaus, Andreas Brachmann, Andreas Klingl, Alexander Goesmann, Karina Brinkrolf, Kai Papenfort, Silke Robatzek   +9 more
wiley   +1 more source

AcrDB update: Predicted 3D structures of anti‐CRISPRs in human gut viromes

Protein Science, Volume 34, Issue 6, June 2025.
Abstract Anti‐CRISPR (Acr) proteins play a key role in phage‐host interactions and hold great promise for advancing genome‐editing technologies. However, finding new Acrs has been challenging due to their low sequence similarity. Recent advances in protein structure prediction have opened new pathways for Acr discovery by using 3D structure similarity.
Minal Khatri, N. R. Siva Shanmugam, Xinpeng Zhang, Revanth Sai Kumar Reddy Patel, Yanbin Yin   +4 more
wiley   +1 more source

Regulating Toxin-Antitoxin Expression: Controlled Detonation of Intracellular Molecular Timebombs

Toxins, 2014
Genes for toxin-antitoxin (TA) complexes are widely disseminated in bacteria, including in pathogenic and antibiotic resistant species. The toxins are liberated from association with the cognate antitoxins by certain physiological triggers to impair ...
Finbarr Hayes, Barbara Kędzierska
doaj   +1 more source

Food‐Derived Bioactive Peptides With Anti‐Diabetic and Antimicrobial Potential: An Updated Review on Current Trends and Challenges

Sustainable Food Proteins, Volume 3, Issue 2, June 2025.
Food‐derived bioactive peptides with anti‐diabetic and antimicrobial potential: An updated review on current trends and challenges. ABSTRACT The exploration of bioactive peptides derived from diverse food sources demonstrates their potential to provide advantages beyond basic nutrition, such as immunological support, antibacterial activities, and ...
Prashantkumar Natubhai Padhiyar, Brij Pal Singh, Preetam Sarkar, Subrota Hati   +3 more
wiley   +1 more source