Results 31 to 40 of about 424 (50)

Characterization of the interaction and cross-regulation of three Mycobacterium tuberculosis RelBE modules. [PDF]

PLoS ONE, 2010
RelBE represents a typical bacterial toxin-antitoxin (TA) system. Mycobacterium tuberculosis H37Rv, the pathogen responsible for human tuberculosis, contains three RelBE-like modules, RelBE, RelFG, and RelJK, which are at least partly expressed in human ...
Min Yang, Chunhui Gao, Yi Wang, Hua Zhang, Zheng-Guo He   +4 more
doaj   +1 more source

The VapBC-4 Characterization Indicates It Is a Bona Fide Toxin-Antitoxin Module of Leptospira interrogans: Initial Evidence for a Role in Bacterial Adaptation

Microorganisms
Toxin-antitoxin (TA) systems are one of the bacterial adaptation mechanisms to adverse conditions. Leptospira interrogans serovar Copenhageni contains nine putative TA systems.
Bruna Oliveira Pigatto Azevedo, Deborah Kohn Damiano, Aline Florencio Teixeira, Ana Lucia Tabet Oller Nascimento, Luis Guilherme Virgilio Fernandes, Alexandre Paulo Yague Lopes   +5 more
doaj   +1 more source

Excitable dynamics through toxin-induced mRNA cleavage in bacteria.

PLoS ONE, 2019
Toxin-antitoxin (TA) systems in bacteria and archaea are small genetic elements consisting of the genes coding for an intracellular toxin and an antitoxin that can neutralize this toxin. In various cases, the toxins cleave the mRNA.
Stefan Vet, Alexandra Vandervelde, Lendert Gelens   +2 more
doaj   +1 more source

A novel type I toxin-antitoxin system modulates persister cell formation in Staphylococcus aureus

International Journal of Medical Microbiology, 2020
A plethora of toxin-antitoxin systems exist in bacteria and has multilateral roles in bacterial pathogenesis and virulence. Toxin-antitoxin systems have been involved in persister cell formation in Escherichia coli and Mycobacterium but have not been ...
Gul Habib, Jiade Zhu, Baolin Sun
doaj  

A novel double-ribonuclease toxin-antitoxin system linked to the stress response and survival of Acidovorax citrulli

Microbiology Spectrum, 2023
Toxin-antitoxin (TA) systems are widespread among prokaryotes and can play an important role in the maintenance of genetic elements and pathogen virulence.
Xudong Wang, Yumin Kan, Kaihong Bai, Xiaoli Xu, Xing Chen, Chengxuan Yu, Jia Shi, Na Jiang, Jianqiang Li, Laixin Luo   +9 more
doaj   +1 more source

TisB Protein Protects Escherichia coli Cells Suffering Massive DNA Damage from Environmental Toxic Compounds

mBio, 2022
Toxin-antitoxin systems are genetic elements that are widespread in prokaryotes. Although molecular mode of action of many of these toxins has been identified, their biological functions are mostly unknown.
Wei-Lin Su, Marie-Florence Bredèche, Sara Dion, Julie Dauverd, Bénédicte Condamine, Arnaud Gutierrez, Erick Denamur, Ivan Matic   +7 more
doaj   +1 more source

Understanding the physiological role and cross-interaction network of VapBC35 toxin-antitoxin system from Mycobacterium tuberculosis

Communications Biology
The VapBC toxin-antitoxin (TA) system, composed of VapC toxin and VapB antitoxin, has gained attention due to its relative abundance in members of the M. tuberculosis complex.
Neelam Singh, Gopinath Chattopadhyay, Niranjana Sri Sundaramoorthy, Raghavan Varadarajan, Ramandeep Singh   +4 more
doaj   +1 more source

A competence-regulated toxin-antitoxin system in Haemophilus influenzae.

PLoS ONE, 2020
Natural competence allows bacteria to respond to environmental and nutritional cues by taking up free DNA from their surroundings, thus gaining both nutrients and genetic information.
Hailey Findlay Black, Scott Mastromatteo, Sunita Sinha, Rachel L Ehrlich, Corey Nislow, Joshua Chang Mell, Rosemary J Redfield   +6 more
doaj   +1 more source

A differential effect of E. coli toxin-antitoxin systems on cell death in liquid media and biofilm formation. [PDF]

PLoS ONE, 2009
Toxin-antitoxin (TA) modules are gene pairs specifying for a toxin and its antitoxin and are found on the chromosomes of many bacteria including pathogens. Here we report how each of five such TA systems in E. coli affect bacterial cell death differently
Ilana Kolodkin-Gal, Reut Verdiger, Ayalla Shlosberg-Fedida, Hanna Engelberg-Kulka   +3 more
doaj   +1 more source

Toxin-Antitoxin Systems: A Key Role on Persister Formation in Salmonella enterica Serovar Typhimurium

Infection and Drug Resistance, 2022
Made Rai Dwitya Wiradiputra,1,2 Piyatip Khuntayaporn,1,3 Krit Thirapanmethee,1,3 Mullika Traidej Chomnawang1,3 1Antimicrobial Resistance Interdisciplinary Group (AmRIG), Faculty of Pharmacy, Mahidol University, Bangkok, Thailand; 2Biopharmaceutical ...
Wiradiputra MRD, Khuntayaporn P, Thirapanmethee K, Chomnawang MT   +3 more
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