Results 71 to 80 of about 24,156 (244)

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

Minimalistic mycoplasmas harbor different functional toxin-antitoxin systems

PLOS Genetics, 2021
Mycoplasmas are minute bacteria controlled by very small genomes ranging from 0.6 to 1.4 Mbp. They encompass several important medical and veterinary pathogens that are often associated with a wide range of chronic diseases. The long persistence of mycoplasma cells in their hosts can exacerbate the spread of antimicrobial resistance observed for many ...
Virginia Hill, Hatice Akarsu, Rubén Sánchez Barbarroja, Valentina L. Cippà, Peter Kuhnert, Martin Heller, Laurent Falquet, Manfred Heller, Michael H. Stoffel, Fabien Labroussaa, Joerg Jores   +10 more
openaire   +5 more sources

Characterization of HicAB toxin-antitoxin module of Sinorhizobium meliloti

BMC Microbiology, 2019
Background Toxin-antitoxin (TA) systems are little genetic units generally composed of two genes encoding antitoxin and toxin. These systems are known to be involved in many functions that can lead to growth arrest and cell death.
Manon Thomet, Annie Trautwetter, Gwennola Ermel, Carlos Blanco   +3 more
doaj   +1 more source

SUPER: Upcycling Genetic Parts for Precise Gene Expression Control, Leakage Minimization, and Genetic Circuit Stability

Advanced Science, EarlyView.
To precisely modulate natural and synthetic regulatory parts, SUPER is introduced as a sophisticated and tunable controller of genetic devices without requiring sequence modification on the target. SUPER enhances dynamic range of RNA‐, chemical‐, temperature‐, and protein‐responsive biosensors up to 1011%, and converts biosensors to cover an expanded ...
Taeyang Heo, Dongwon Park, Woosub Shin, Jongmin Kim   +3 more
wiley   +1 more source

Toxin-antitoxin system [PDF]

, 2018
Bakterije su razvile iznimnu sposobnost prilagodbe na različite životne uvjete. Uz pomoć raznih sustava i mehanizama daju brz stanični odgovor na stresore, tretman antibiotikom, stanje gladi i ostale nepovoljne uvjete. Jedan takav sustav pronađen je u
Matković, Katarina
core   +2 more sources

Comparative Genomics of 9 Novel Paenibacillus Larvae Bacteriophages [PDF]

, 2016
American Foulbrood Disease, caused by the bacterium Paenibacillus larvae, is one of the most destructive diseases of the honeybee, Apis mellifera. Our group recently published the sequences of 9 new phages with the ability to infect and lyse P.
Amy, Penny S., LeBlanc, Lucy, Stamereilers, Casey, Tsourkas, Philippos K., Yost, Diane   +4 more
core   +2 more sources

Engineered Stable, Antibiotic‐Free, High‐Level Protein Expression in the Probiotic Chassis Escherichia coli Nissle 1917

Biotechnology and Bioengineering, EarlyView.
The probiotic E. coli Nissle 1917 was engineered to enable stable and antibiotic free protein expression platforms using native plasmids. Further modification aids in the production of high‐level protein expression for antimicrobial secretion whose activity is comparable to industry standard E. coli BL21.
Halimatun Sakdiah Zainuddin, Sanjeeva Kumar Murali, Thomas J. Mansell   +2 more
wiley   +1 more source

Oxidative Treatment for Reducing Persistent Populations of Escherichia coli Under Amoxicillin and Gentamicin Pressure

Journal of Biophotonics, EarlyView.
Photodynamic inactivation (PDI) with methylene blue and 660 nm LED enhances antibiotic killing of bacteria, accelerating time‐kill kinetics and reducing the MDK99 compared to antibiotics alone. SEM confirms effective cellular damage, demonstrating that PDI potentiates amoxicillin and gentamicin against tolerant bacterial populations. ABSTRACT Bacterial
Bruna C. Correa, Maria Vitória S. Pereira, Vanderlei S. Bagnato, Kate C. Blanco   +3 more
wiley   +1 more source

What traits are carried on mobile genetic elements, and why? [PDF]

, 2010
Although similar to any other organism, prokaryotes can transfer genes vertically from mother cell to daughter cell, they can also exchange certain genes horizontally.
A Gardner, A Gardner, A Gardner, A Gardner, A Gardner, A Gardner, A Mochizuki, A Norman, A Philppon, A Wagner, AD O’Brien, AS Griffin, B Sanchez, BJ Crespi, BK Kozlowicz, BMM Ahmer, BR Levin, C Buchrieser, CE White, CF Amabile-Cuevas, CG Kurland, CM Thomas, CM Yates, CT Bergstrom, D Gevers, D J Rankin, DJ Rankin, DM Livermore, E Cascales, E Cascales, E Lerat, E P C Rocha, E Polzleitner, ES Egan, F Bushman, F de la Cruz, F Delsuc, F Dionisio, F Dionisio, F Harrison, F Rousset, FM Stewart, FR Slater, G Gil, G Hardin, GA Dykes, H Knothe, H Ochman, I Chen, I Kobayashi, I Rasched, J Hacker, J Lederberg, J Paulsson, J Smith, J Zupan, JB Ferdy, JB Xavier, JC Diaz Ricci, JE Bouma, JL Martinez, JL Martínez, JL Sachs, JL Sachs, JR van der Ploeg, K Lee, KM Oliver, KR Foster, KR Foster, KR Foster, L Buts, L Chao, L Keller, L Lehmann, L Lehmann, L Riboli-Sasco, L Van Melderen, LE Orgel, LJ Johnson, LN Lili, LS Frost, M Achtman, M Ackermann, M Touchon, MA Riley, MI Bahl, MI Bahl, MK Waldor, MP Nuti, N Goldenfeld, ND Zinder, PB Rainey, PE Turner, PE Turner, R Barrangou, R Korona, RD Magnuson, RE Fox, RJ Ellis, RJF Haft, RM Anderson, RM Anderson, RM May, S Alizon, S P Brown, SA West, SA West, SA West, SA West, SC Slater, SJ Sorensen, SM Faruque, SP Brown, SP Brown, SP Brown, SP Brown, SR Bordenstein, T Nogueira, TF Cooper, TF Cooper, VL Arcus, WD Hamilton, WD Hamilton, WG Eberhard   +123 more
core   +3 more sources

Generation of a toxin/antitoxin-based counterselection marker for Chlamydia trachomatis

Infection and Immunity
Chlamydia trachomatis is the leading cause of bacterial sexually transmitted infection in the United States. The high rate of asymptomatic cases and absence of a vaccine often leave infections untreated, increasing the risk of serious complications in ...
Eleanor Steiner, Samantha D’Spain, Rachel Ende, Isabelle Derré   +3 more
doaj   +1 more source