Results 171 to 180 of about 18,051 (202)

Toxin/antitoxin systems induce persistence and work in concert with restriction/modification systems to inhibit phage. [PDF]

Microbiol Spectr
Fernández-García L, Song S, Kirigo J, Battisti ME, Petersen ME, Tomás M, Wood TK.   +6 more
europepmc   +1 more source

Unraveling the evolutionary dynamics of toxin-antitoxin systems in diverse genetic lineages of Escherichia coli including the high-risk clonal complexes. [PDF]

mBio
Singh A, Lankapalli AK, Mendem SK, Semmler T, Ahmed N.   +4 more
europepmc   +1 more source

Type II and IV toxin-antitoxin systems coordinately stabilize the integrative and conjugative element of the ICESa2603 family conferring multiple drug resistance in Streptococcus suis. [PDF]

PLoS Pathog
Gu Q, Zhu X, Yu Y, Jiang T, Pan Z, Ma J, Yao H.   +6 more
europepmc   +1 more source

Type II toxin: antitoxin systems. More than small selfish entities? [PDF]

core   +1 more source

Genome sequence of Helicobacter suis supports its role in gastric pathology [PDF]

, 2010
De Groote, Dominic, Ducatelle, Richard, Flahou, Bram, Haesebrouck, Freddy, Pasmans, Frank, Smet, Annemieke, Van Criekinge, Wim, Vandekerckhove, Tom, Vermoote, Miet   +8 more
core   +1 more source

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Toxin-antitoxin RNA pairs safeguard CRISPR-Cas systems

Science, 2021
Small RNAs guard CRISPR-Cas The microbial adaptive immunity system CRISPR-Cas benefits microbes by warding off genetic invaders, but it also inflicts a fitness cost because of occasional autoimmune reactions, rendering CRISPR loci evolutionarily unstable.
Ming Li, Luyao Gong, Feiyue Cheng
exaly   +3 more sources

Toxin–antitoxin systems: Classification, biological roles, and applications

Microbiological Research, 2022
Toxin-antitoxin (TA) systems, composed of a stable toxin and a cognate unstable antitoxin, are ubiquitous in the genomes of bacteria and archaea. Under suitable growth conditions, an antitoxin prevents its cognate toxin from inducing toxicity; nonetheless, under stress or plasmid loss, it is either rapidly degraded or downregulated, thereby freeing the
Chengkun Zheng, Xin-An Jiao
exaly   +3 more sources

Ribonucleases in bacterial toxin–antitoxin systems

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2013
Toxin-antitoxin (TA) systems are widespread in bacteria and archaea and play important roles in a diverse range of cellular activities. TA systems have been broadly classified into 5 types and the targets of the toxins are diverse, but the most frequently used cellular target is mRNA.
Cook, Gregory M., Robson, Jennifer R., Frampton, Rebekah A., McKenzie, Joanna, Przybilski, Rita, Fineran, Peter C., Arcus, Vickery L.   +6 more
openaire   +3 more sources

Chromosomal bacterial type II toxin–antitoxin systems

Canadian Journal of Microbiology, 2012
Most prokaryotic chromosomes contain a number of toxin–antitoxin (TA) modules consisting of a pair of genes that encode 2 components, a stable toxin and its cognate labile antitoxin. TA systems are also known as addiction modules, since the cells become “addicted” to the short-lived antitoxin product (the unstable antitoxin is degraded faster than the
Mohammad Adnan, Syed, Céline M, Lévesque   +1 more
openaire   +2 more sources